| ARI | Pavin Smith | The Arizona Diamondbacks activated INF Pavin Smith from the 60-day injured list. |
| CIN | Brandon Williamson | The Cincinnati Reds activated LHP Brandon Williamson from the 60-day injured list. |
| LAD | Brusdar Graterol | The Los Angeles Dodgers activated RHP Brusdar Graterol from the 60-day injured list. |
| ARI | A.J. Puk | The Arizona Diamondbacks activated LHP A.J. Puk from the 60-day injured list. |
| TEX | Marcus Semien | The Texas Rangers activated INF Marcus Semien from the 60-day injured list. |
| CIN | Rhett Lowder | The Cincinnati Reds activated RHP Rhett Lowder from the 60-day injured list. |
| NYY | Oswaldo Cabrera | The New York Yankees activated INF Oswaldo Cabrera from the 60-day injured list. |
| MIA | Max Meyer | The Miami Marlins activated RHP Max Meyer from the 60-day injured list. |
| NYY | Clarke Schmidt | The New York Yankees activated RHP Clarke Schmidt from the 60-day injured list. |
| TEX | Cody Bradford | The Texas Rangers activated LHP Cody Bradford from the 60-day injured list. |
| TEX | Sam Haggerty | The Texas Rangers activated OF Sam Haggerty from the 60-day injured list. |
| NYY | Gerrit Cole | The New York Yankees activated RHP Gerrit Cole from the 60-day injured list. |
| NYM | Max Kranick | The New York Mets activated RHP Max Kranick from the 60-day injured list. |
| ARI | Austin Pope | The Arizona Diamondbacks designated RHP Austin Pope for assignment. He elected free agency. |
| ARI | Corbin Burnes | The Arizona Diamondbacks activated RHP Corbin Burnes from the 60-day injured list. |
| NYM | Danny Young | The New York Mets activated LHP Danny Young from the 60-day injured list. |
| NYY | Jake Cousins | The New York Yankees activated RHP Jake Cousins from the 60-day injured list. |
| CIN | Julian Aguiar | The Cincinnati Reds activated RHP Julian Aguiar from the 60-day injured list. |
| CIN | Tyler Callihan | The Cincinnati Reds activated OF Tyler Callihan from the 60-day injured list. |
| TEX | Nathan Eovaldi | The Texas Rangers activated RHP Nathan Eovaldi from the 60-day injured list. |
| SF | Erik Miller | The San Francisco Giants activated LHP Erik Miller from the 60-day injured list. |
| TEX | Evan Carter | The Texas Rangers activated OF Evan Carter from the 60-day injured list. |
| MIA | Christian Roa | The Miami Marlins sent RHP Christian Roa outright to the minors. |
| CHC | Justin Steele | The Chicago Cubs activated LHP Justin Steele from the 60-day injured list. |
| ARI | Justin Martinez | The Arizona Diamondbacks activated RHP Justin Martinez from the 60-day injured list. |
| LAD | Nick Frasso | The Los Angeles Dodgers activated RHP Nick Frasso from the 60-day injured list. |
| ARI | Kevin Ginkel | The Arizona Diamondbacks activated RHP Kevin Ginkel from the 60-day injured list. |
| LAD | Evan Phillips | The Los Angeles Dodgers activated RHP Evan Phillips from the 60-day injured list. |
| NYM | Dedniel Nunez | The New York Mets activated RHP Dedniel Núñez from the 60-day injured list. |
| BAL | Carson Ragsdale | The Baltimore Orioles designated RHP Carson Ragsdale for assignment. |
| LAD | Gavin Stone | The Los Angeles Dodgers activated RHP Gavin Stone from the 60-day injured list. |
| ARI | Blake Walston | The Arizona Diamondbacks activated LHP Blake Walston from the 60-day injured list. |
| ARI | Cristian Mena | The Arizona Diamondbacks activated RHP Cristian Mena from the 60-day injured list. |
| MIA | Andrew Nardi | The Miami Marlins activated LHP Andrew Nardi from the 60-day injured list. |
| MIA | Braxton Garrett | The Miami Marlins activated LHP Braxton Garrett from the 60-day injured list. |
| SF | Randy Rodriguez | The San Francisco Giants activated RHP Randy Rodríguez from the 60-day injured list. |
| LAD | Kyle Hurt | The Los Angeles Dodgers activated RHP Kyle Hurt from the 60-day injured list. |
| NYM | Frankie Montas | The New York Mets activated RHP Frankie Montas from the 60-day injured list. |
| NYM | Christian Scott | The New York Mets activated RHP Christian Scott from the 60-day injured list. |
| TEX | Josh Sborz | The Texas Rangers activated RHP Josh Sborz from the 60-day injured list. |
| LAD | River Ryan | The Los Angeles Dodgers activated RHP River Ryan from the 60-day injured list. |
| ARI | Tommy Henry | The Arizona Diamondbacks activated LHP Tommy Henry from the 60-day injured list. |
| MIA | Anthony Bender | The Miami Marlins activated RHP Anthony Bender from the 60-day injured list. |
| ARI | Christian Montes De Oca | The Arizona Diamondbacks activated RHP Christian Montes De Oca from the 60-day injured list. |
| NYM | Tylor Megill | The New York Mets activated RHP Tylor Megill from the 60-day injured list. |
| NYM | A.J. Minter | The New York Mets activated LHP A.J. Minter from the 60-day injured list. |
| BAL | Dylan Carlson | Baltimore Orioles OF Dylan Carlson declared free agency. |
| CIN | Carson Spiers | The Cincinnati Reds activated RHP Carson Spiers from the 60-day injured list. |
| BAL | Brandon Young | The Baltimore Orioles activated RHP Brandon Young from the 60-day injured list. |
| CLE | Ben Lively | The Cleveland Guardians released RHP Ben Lively. |
| STL | Anthony Veneziano | The St. Louis Cardinals released LHP Anthony Veneziano. |
| CLE | Will Wilson | The Cleveland Guardians released INF Will Wilson. |
| ATL | Michael Siani | The Atlanta Braves claimed OF Michael Siani off waivers from the St. Louis Cardinals. |
| TB | Stuart Fairchild | Tampa Bay Rays OF Stuart Fairchild declared free agency. |
| NYY | Kervin Castro | The New York Yankees selected the contract of RHP Kervin Castro from the minors. |
| MIL | Logan Henderson | The Milwaukee Brewers activated RHP Logan Henderson from the 60-day injured list. |
| STL | Zack Thompson | The St. Louis Cardinals released LHP Zack Thompson. |
| CLE | Andrew Walters | The Cleveland Guardians activated RHP Andrew Walters from the 60-day injured list. |
| CLE | Matt Krook | The Cleveland Guardians released LHP Matt Krook. |
| LAD | Robinson Ortiz | The Los Angeles Dodgers selected the contract of LHP Robinson Ortiz from the minors. |
| BAL | Anthony Nunez | The Baltimore Orioles selected the contract of RHP Anthony Nunez from the minors. |
| TB | Caleb Boushley | Tampa Bay Rays RHP Caleb Boushley declared free agency. |
| STL | Bryan Torres | The St. Louis Cardinals selected the contract of C Bryan Torres from the minors. |
| BAL | Felix Bautista | The Baltimore Orioles activated RHP Félix Bautista from the 60-day injured list. |
| BAL | Grayson Rodriguez | The Baltimore Orioles activated RHP Grayson Rodriguez from the 60-day injured list. |
| BAL | Josh Walker | The Baltimore Orioles designated LHP Josh Walker for assignment. |
| CLE | Dom Nunez | The Cleveland Guardians released C Dom Nuñez. |
| MIL | Garrett Mitchell | The Milwaukee Brewers activated OF Garrett Mitchell from the 60-day injured list. |
| TB | Alex Faedo | Tampa Bay Rays RHP Alex Faedo declared free agency. |
| BAL | Shawn Dubin | The Baltimore Orioles sent RHP Shawn Dubin outright to the minors. |
| HOU | Hayden Wesneski | The Houston Astros activated RHP Hayden Wesneski from the 60-day injured list. |
| CLE | Will Brennan | The Cleveland Guardians activated OF Will Brennan from the 60-day injured list. |
| HOU | Luis Garcia | Houston Astros RHP Luis Garcia declared free agency. |
| CLE | Kolby Allard | The Cleveland Guardians released LHP Kolby Allard. |
| CLE | John Means | The Cleveland Guardians declined the option of LHP John Means, making him a free agent. |
| CIN | Sam Benschoter | The Cincinnati Reds sent RHP Sam Benschoter outright to the minors. |
| CLE | Sam Hentges | The Cleveland Guardians activated LHP Sam Hentges from the 60-day injured list. |
| BAL | Daniel Johnson | The Baltimore Orioles sent OF Daniel Johnson outright to the minors. |
| BAL | Jorge Mateo | Baltimore Orioles INF Jorge Mateo declared free agency. |
| TB | Taylor Walls | The Tampa Bay Rays activated INF Taylor Walls from the 60-day injured list. |
| MIN | Justin Topa | The Minnesota Twins sent RHP Justin Topa outright to the minors. |
| ATL | AJ Smith-Shawver | The Atlanta Braves activated RHP AJ Smith-Shawver from the 60-day injured list. |
| MIN | Thomas Hatch | The Minnesota Twins released RHP Thomas Hatch. |
| ATL | Grant Holmes | The Atlanta Braves activated RHP Grant Holmes from the 60-day injured list. |
| DET | Jackson Jobe | The Detroit Tigers activated RHP Jackson Jobe from the 60-day injured list. |
| DET | Ty Madden | The Detroit Tigers activated RHP Ty Madden from the 60-day injured list. |
| ATL | Austin Riley | The Atlanta Braves activated INF Austin Riley from the 60-day injured list. |
| ATL | Joel Payamps | The Atlanta Braves sent RHP Joel Payamps outright to the minors. |
| DET | Jack Little | The Detroit Tigers claimed RHP Jack Little off waivers from the Pittsburgh Pirates. |
| NYM | Nick Madrigal | New York Mets INF Nick Madrigal declared free agency. |
| ATL | Daysbel Hernandez | The Atlanta Braves activated RHP Daysbel Hernández from the 60-day injured list. |
| PHI | Daniel Robert | The Philadelphia Phillies activated RHP Daniel Robert from the 60-day injured list. |
| PIT | Ronny Simon | The Pittsburgh Pirates activated INF Ronny Simon from the 60-day injured list. |
| SF | Mason Black | The San Francisco Giants designated RHP Mason Black for assignment. |
| DET | Reese Olson | The Detroit Tigers activated RHP Reese Olson from the 60-day injured list. |
| TB | Kameron Misner | The Tampa Bay Rays designated OF Kameron Misner for assignment. |
| PIT | Michael Darrell-Hicks | The Pittsburgh Pirates designated RHP Michael Darrell-Hicks for assignment. |
| DET | Jason Foley | The Detroit Tigers claimed RHP Jason Foley from the 60-day injured list. |
| MIN | Anthony Misiewicz | The Minnesota Twins released LHP Anthony Misiewicz. |
| ATL | Chuckie Robinson | The Atlanta Braves sent C Chuckie Robinson outright to the minors. |
| DET | Beau Brieske | The Detroit Tigers activated RHP Beau Brieske from the 60-day injured list. |
| PHI | Zack Wheeler | The Philadelphia Phillies activated RHP Zack Wheeler from the 60-day injured list. |
| MIN | Michael Tonkin | The Minnesota Twins released RHP Michael Tonkin. |
| PIT | Jared Jones | The Pittsburgh Pirates activated RHP Jared Jones from the 60-day injured list. |
| TB | Bob Seymour | The Tampa Bay Rays designated INF Bob Seymour for assignment. |
| MIA | Zach Brzykcy | The Miami Marlins claimed RHP Zach Brzykcy off waivers from the Washington Nationals. |
| PIT | Liover Peguero | The Pittsburgh Pirates sent INF Liover Peguero outright to the minors. |
| MIN | Alan Roden | The Minnesota Twins activated OF Alan Roden from the 60-day injured list. |
| ATL | Jake Fraley | The Atlanta Braves activated OF Jake Fraley from the 60-day injured list. |
| TB | Jake Fraley | The Tampa Bay Rays claimed OF Jake Fraley off waivers from the Atlanta Braves. |
| TB | Forrest Whitley | The Tampa Bay Rays selected the contract of RHP Forrest Whitley from the minors. |
| LAD | Tony Gonsolin | The Los Angeles Dodgers designated RHP Tony Gonsolin for assignment. |
| CIN | Roddery Munoz | The Cincinnati Reds claimed RHP Roddery Muñoz off waivers from the St. Louis Cardinals. |
| DET | Sean Guenther | The Detroit Tigers activated LHP Sean Guenther from the 60-day injured list. |
| LAD | Ryan Ward | The Los Angeles Dodgers selected the contract of OF Ryan Ward from the minors. |
| ATL | Sean Murphy | The Atlanta Braves activated C Sean Murphy from the 60-day injured list. |
| MIN | Jose Miranda | The Minnesota Twins released INF Jose Miranda. |
| ATL | Aaron Bummer | The Atlanta Braves activated LHP Aaron Bummer from the 60-day injured list. |
| PHI | Rafael Lantigua | The Philadelphia Phillies INF Rafael Lantigua declared free agency. |
| PHI | Rafael Lantigua | The Philadelphia Phillies sent INF Rafael Lantigua outright to the minors. |
| TB | Brian Van Kirk | The Tampa Bay Rays activated RHP Brian Van Belle from the 60-day injured list and designated him for assignment. |
| LAA | Cody Laweryson | The Los Angeles Angels claimed RHP Cody Laweryson off waivers from the Minnesota Twins. |
| NYM | Jose Castillo | The New York Mets claimed LHP José Castillo off waivers from the Baltimore Orioles. |
| ATL | Reynaldo Lopez | The Atlanta Braves activated RHP Reynaldo López from the 60-day injured list. |
| PIT | Enmanuel Valdez | The Pittsburgh Pirates activated INF Enmanuel Valdez from the 60-day injured list. |
| ATL | Joe Jimenez | The Atlanta Braves activated RHP Joe Jiménez from the 60-day injured list. |
| TB | Pete Fairbanks | The Tampa Bay Rays declined the contract option for RHP Pete Fairbanks, making him a free agent. |
| ATL | Austin Cox | The Atlanta Braves sent LHP Austin Cox outright to the minors. |
| ATL | Spencer Schwellenbach | The Atlanta Braves activated RHP Spencer Schwellenbach from the 60-day injured list. |
| LAD | Michael Grove | The Los Angeles Dodgers sent RHP Michael Grove outright to the minors. |
| SF | Reiver Sanmartin | The San Francisco Giants claimed LHP Reiver Sanmartin off waivers from the Cincinnati Reds. |
| SF | Justin Dean | The San Francisco Giants claimed OF Justin Dean off waivers from the Los Angeles Dodgers. |
| PIT | Dugan Darnell | The Pittsburgh Pirates activated RHP Dugan Darnell from the 60-day injured list. |
| PIT | Dugan Darnell | The Pittsburgh Pirates designated RHP Dugan Darnell for assignment. |
| NYM | Ji Hwan Bae | The New York Mets claimed OF Ji Hwan Bae off waivers from the Pittsburgh Pirates. |
| PIT | Endy Rodriguez | The Pittsburgh Pirates activated INF Endy Rodríguez from the 60-day injured list. |
| TB | Nate Lavender | The Tampa Bay Rays activated LHP Nate Lavender from the 60-day injured list and designated him for assignment. |
| BAL | Pedro Leon | The Baltimore Orioles claimed OF Pedro León from the Houston Astros. |
| CWS | Ky Bush | The Chicago White Sox activated LHP Ky Bush from the 60-day injured list. |
| DET | Jose Urquidy | RHP José Urquidy elected free agency. |
| TOR | Brandon Valenzuela | The Toronto Blue Jays selected the contract of C Brandon Valenzuela from the minors. |
| CWS | Prelander Berroa | The Chicago White Sox activated RHP Prelander Berroa from the 60-day injured list. |
| BOS | Marcelo Mayer | The Boston Red Sox activated INF Marcelo Mayer from the 60-day injured list. |
| BOS | Hunter Dobbins | The Boston Red Sox activated RHP Hunter Dobbins from the 60-day injured list. |
| WSH | Josiah Gray | The Washington Nationals activated RHP Josiah Gray from the 60-day injured list. |
| WSH | DJ Herz | The Washington Nationals activated LHP DJ Herz from the 60-day injured list. |
| BOS | Vaughn Grissom | The Boston Red Sox activated INF Vaughn Grissom from the 60-day injured list. |
| WSH | Trevor Williams | The Washington Nationals activated RHP Trevor Williams from the 60-day injured list. |
| BOS | Liam Hendriks | The Boston Red Sox activated RHP Liam Hendriks from the 60-day injured list. |
| BOS | Patrick Sandoval | The Boston Red Sox activated LHP Patrick Sandoval from the 60-day injured list. |
| HOU | Chas McCormick | OF Chas McCormick elected free agency. |
| BOS | Kutter Crawford | The Boston Red Sox activated RHP Kutter Crawford from the 60-day injured list. |
| BOS | Triston Casas | The Boston Red Sox activated INF Triston Casas from the 60-day injured list. |
| WSH | Trey Lipscomb | The Washington Nationals sent INF Trey Lipscomb outright to the minors. |
| WSH | Drew Millas | The Washington Nationals activated C Drew Millas from the 60-day injured list. |
| ATL | Pierce Johnson | RHP Pierce Johnson elected free agency. |
| COL | Garrett Acton | The Colorado Rockies claimed RHP Garrett Acton off waivers from the Tampa Bay Rays. |
| CWS | Drew Thorpe | The Chicago White Sox activated RHP Drew Thorpe from the 60-day injured list. |
| DET | Paul Sewald | RHP Paul Sewald elected free agency. |
| SEA | Ryan Loutos | The Seattle Mariners claimed RHP Ryan Loutos off waivers from the Washington Nationals |
| BOS | Tanner Houck | The Boston Red Sox activated RHP Tanner Houck from the 60-day injured list. |
| BOS | Luis Guerrero | The Boston Red Sox designated RHP Luis Guerrero for assignment. |
| BOS | Luis Guerrero | The Boston Red Sox activated RHP Luis Guerrero from the 60-day injured list. |
| BOS | Josh Winckowski | The Boston Red Sox activated RHP Josh Winckowski from the 60-day injured list. |
| COL | Thairo Estrada | INF Thairo Estrada elected free agency. |
| COL | Thairo Estrada | The Colorado Rockies activated INF Thairo Estrada from the 60-day injured list. |
| TOR | Nick Sandlin | The Toronto Blue Jays activated RHP Nick Sandlin from the 60-day injured list. |
| TOR | Angel Bastardo | The Toronto Blue Jays activated RHP Angel Bastardo from the 60-day injured list. |
| TOR | Dillon Tate | RHP Dillon Tate elected free agency. |
| TOR | Bowden Francis | The Toronto Blue Jays activated RHP Bowden Francis from the 60-day injured list. |
| TOR | Ryan Burr | RHP Ryan Burr elected free agency. |
| TOR | Ryan Burr | The Toronto Blue Jays activated RHP Ryan Burr from the 60-day injured list. |
| TOR | Yimi Garcia | The Toronto Blue Jays activated RHP Yimi García from the 60-day injured list. |
| ATL | Tyler Kinley | RHP Tyler Kinley elected free agency. |
| MIA | Valente Bellozo | The Miami Marlins sent RHP Valente Bellozo outright to the minors. |
| CHC | Justin Turner | INF Justin Turner elected free agency. |
| MIA | Tyler Zuber | The Miami Marlins activated RHP Tyler Zuber from the 60-day injured list. |
| MIA | Tyler Zuber | The Miami Marlins sent RHP Tyler Zuber outright to the minors. |
| LV | Gunnar Hoglund | The Athletics activated RHP Gunnar Hoglund from the 60-day injured list. |
| LV | Grant Holman | The Athletics activated RHP Grant Holman from the 60-day injured list. |
| SD | Jhony Brito | The San Diego Padres activated RHP Jhony Brito from the 60-day injured list. |
| LAA | Ben Joyce | The Los Angeles Angels activated RHP Ben Joyce from the 60-day injured list. |
| LAA | Victor Mederos | The Los Angeles Angels activated RHP Victor Mederos from the 60-day injured list. |
| LAA | Anthony Rendon | The Los Angeles Angels activated INF Anthony Rendon from the 60-day injured list. |
| SD | Joe Musgrove | The San Diego Padres activated RHP Joe Musgrove from the 60-day injured list. |
| TOR | Robinson Pina | The Toronto Blue Jays activated RHP Robinson Piña from the 60-day injured list. |
| TOR | Robinson Pina | The Toronto Blue Jays sent RHP Robinson Piña outright to the minors. |
| SD | Elias Diaz | C Elias Díaz elected free agency. |
| SD | Tyler Wade | INF Tyler Wade elected free agency. |
| SD | Kyle Hart | LHP Kyle Hart elected free agency. |
| MIA | Jesus Tinoco | The Miami Marlins activated RHP Jesus Tinoco from the 60-day injured list. |
| MIA | Jesus Tinoco | The Miami Marlins sent RHP Jesus Tinoco outright to the minors. |
| SD | Jason Adam | The San Diego Padres activated RHP Jason Adam from the 60-day injured list. |
| LAA | Jorge Soler | The Los Angeles Angels activated OF Jorge Soler from the 60-day injured list. |
| LAA | Gustavo Campero | The Los Angeles Angels activated OF Gustavo Campero from the 60-day injured list. |
| LAA | Reid Detmers | The Los Angeles Angels activated LHP Reid Detmers from the 60-day injured list. |
| LV | Luis Medina | The Athletics activated RHP Luis Medina from the 60-day injured list. |
| LV | Austin Wynns | The Athletics activated C Austin Wynns from the 60-day injured list. |
