

| No starting lineup changes performed this week. |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 10:52am ET |
| Benched | QB | Daniel Jones IND | Owner | Thu Nov 27 10:52am ET |
| Started | TE | Cade Otton TB | Owner | Tue Nov 25 3:07pm ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 3:07pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 3:07pm ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Nov 25 3:07pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 3:07pm ET |
| Started | QB | Daniel Jones IND | Owner | Tue Nov 25 3:07pm ET |
| Benched | TE | Cade Otton TB | Owner | Tue Nov 25 8:48am ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 8:48am ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 8:48am ET |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Nov 25 8:48am ET |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 8:48am ET |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 25 8:48am ET |
| Started | RB | Rico Dowdle CAR | Owner | Fri Nov 28 6:04pm ET |
| Benched | RB | Kenneth Gainwell PIT | Owner | Fri Nov 28 6:04pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Thu Nov 27 12:19am ET |
| Benched | WR | Alec Pierce IND | Owner | Thu Nov 27 12:19am ET |
| Started | WR | Alec Pierce IND | Owner | Wed Nov 26 5:21pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Wed Nov 26 5:21pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 12:15pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 12:15pm ET |
| Started | WR | Alec Pierce IND | Owner | Tue Nov 25 8:12am ET |
| Benched | WR | Christian Kirk HOU | Owner | Tue Nov 25 8:12am ET |
| Started | WR | Christian Kirk HOU | Owner | Tue Nov 25 8:10am ET |
| Benched | RB | Rico Dowdle CAR | Owner | Tue Nov 25 8:10am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 2:32am ET |
| Benched | TE | Hunter Henry NE | Owner | Tue Nov 25 5:51pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 5:51pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 25 12:10pm ET |
| Benched | TE | Isaiah Likely BAL | Owner | Tue Nov 25 12:10pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 12:10pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 12:10pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Thu Nov 27 7:37am ET |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 7:37am ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 10:40am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 10:40am ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 9:05am ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 9:05am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Fri Nov 28 5:20pm ET |
| Benched | WR | Emeka Egbuka TB | Owner | Fri Nov 28 5:20pm ET |
| Started | WR | Emeka Egbuka TB | Owner | Wed Nov 26 2:49pm ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 2:49pm ET |
| Started | TE | Zach Ertz WAS | Owner | Wed Nov 26 2:48pm ET |
| Benched | TE | David Njoku CLE | Owner | Wed Nov 26 2:48pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 9:39am ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 9:39am ET |
| Benched | WR | Emeka Egbuka TB | Owner | Wed Nov 26 9:39am ET |
| Benched | RB | Michael Carter ARI | Owner | Wed Nov 26 9:39am ET |
| Benched | RB | Terrell Jennings NE | Owner | Fri Nov 28 10:09pm ET |
| Started | WR | Chris Olave NO | Owner | Fri Nov 28 10:09pm ET |
| Benched | WR | Chris Olave NO | Owner | Thu Nov 27 12:08pm ET |
| Started | RB | Terrell Jennings NE | Owner | Thu Nov 27 12:08pm ET |
| Benched | QB | Justin Fields NYJ | Owner | Tue Nov 25 4:25pm ET |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 4:25pm ET |
| Started | QB | Cam Ward TEN | Owner | Tue Nov 25 4:25pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 4:25pm ET |
| Benched | QB | Brock Purdy SF | Owner | Wed Nov 26 6:41pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 6:41pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 6:41pm ET |
| Started | WR | Darnell Mooney ATL | Owner | Wed Nov 26 6:41pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 9:11am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 8:53am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 8:53am ET |
| Benched | TE | Tyler Warren IND | Owner | Wed Nov 26 8:30pm ET |
| Started | RB | Jaylen Warren PIT | Owner | Wed Nov 26 8:30pm ET |
| Benched | D/ST | New England Patriots NE | Owner | Tue Nov 25 4:58pm ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 25 4:58pm ET |