

| No starting lineup changes performed this week. |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 9:52am CT |
| Benched | QB | Daniel Jones IND | Owner | Thu Nov 27 9:52am CT |
| Started | TE | Cade Otton TB | Owner | Tue Nov 25 2:07pm CT |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 2:07pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 2:07pm CT |
| Started | RB | D'Andre Swift CHI | Owner | Tue Nov 25 2:07pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 2:07pm CT |
| Started | QB | Daniel Jones IND | Owner | Tue Nov 25 2:07pm CT |
| Benched | TE | Cade Otton TB | Owner | Tue Nov 25 7:48am CT |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 7:48am CT |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 7:48am CT |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Nov 25 7:48am CT |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 7:48am CT |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 25 7:48am CT |
| Started | RB | Rico Dowdle CAR | Owner | Fri Nov 28 5:04pm CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Fri Nov 28 5:04pm CT |
| Started | WR | DeVonta Smith PHI | Owner | Wed Nov 26 11:19pm CT |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 11:19pm CT |
| Started | WR | Alec Pierce IND | Owner | Wed Nov 26 4:21pm CT |
| Benched | WR | DeVonta Smith PHI | Owner | Wed Nov 26 4:21pm CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 11:15am CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 11:15am CT |
| Started | WR | Alec Pierce IND | Owner | Tue Nov 25 7:12am CT |
| Benched | WR | Christian Kirk HOU | Owner | Tue Nov 25 7:12am CT |
| Started | WR | Christian Kirk HOU | Owner | Tue Nov 25 7:10am CT |
| Benched | RB | Rico Dowdle CAR | Owner | Tue Nov 25 7:10am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 1:32am CT |
| Benched | TE | Hunter Henry NE | Owner | Tue Nov 25 4:51pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 4:51pm CT |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 25 11:10am CT |
| Benched | TE | Isaiah Likely BAL | Owner | Tue Nov 25 11:10am CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 11:10am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 11:10am CT |
| Benched | WR | Khalil Shakir BUF | Owner | Sun Nov 30 5:06am CT |
| Started | RB | Kimani Vidal LAC | Owner | Sun Nov 30 5:06am CT |
| Benched | TE | Jake Ferguson DAL | Owner | Thu Nov 27 6:37am CT |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 6:37am CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 9:40am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 9:40am CT |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 8:05am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 8:05am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Fri Nov 28 4:20pm CT |
| Benched | WR | Emeka Egbuka TB | Owner | Fri Nov 28 4:20pm CT |
| Started | WR | Emeka Egbuka TB | Owner | Wed Nov 26 1:49pm CT |
| Benched | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 1:49pm CT |
| Started | TE | Zach Ertz WAS | Owner | Wed Nov 26 1:48pm CT |
| Benched | TE | David Njoku CLE | Owner | Wed Nov 26 1:48pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 8:39am CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 8:39am CT |
| Benched | WR | Emeka Egbuka TB | Owner | Wed Nov 26 8:39am CT |
| Benched | RB | Michael Carter ARI | Owner | Wed Nov 26 8:39am CT |
| Benched | RB | Terrell Jennings NE | Owner | Fri Nov 28 9:09pm CT |
| Started | WR | Chris Olave NO | Owner | Fri Nov 28 9:09pm CT |
| Benched | WR | Chris Olave NO | Owner | Thu Nov 27 11:08am CT |
| Started | RB | Terrell Jennings NE | Owner | Thu Nov 27 11:08am CT |
| Benched | QB | Justin Fields NYJ | Owner | Tue Nov 25 3:25pm CT |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 3:25pm CT |
| Started | QB | Cam Ward TEN | Owner | Tue Nov 25 3:25pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 3:25pm CT |
| Benched | QB | Brock Purdy SF | Owner | Wed Nov 26 5:41pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 5:41pm CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 5:41pm CT |
| Started | WR | Darnell Mooney ATL | Owner | Wed Nov 26 5:41pm CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 8:11am CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 7:53am CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 7:53am CT |
| Benched | TE | Tyler Warren IND | Owner | Wed Nov 26 7:30pm CT |
| Started | RB | Jaylen Warren PIT | Owner | Wed Nov 26 7:30pm CT |
| Benched | D/ST | New England Patriots NE | Owner | Tue Nov 25 3:58pm CT |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 25 3:58pm CT |