Oneil Cruz and Nick Gonzales each had clutch two-run hits to back up a gem by Paul Skenes and propel the host Pittsburgh Pirates to a 7-1 victory over the San Diego Padres on Tuesday.

Skenes (2-1) carried a no-hitter into the sixth inning before allowing a one-out single by Fernando Tatis Jr. Throwing 87 pitches, Skenes gave up one run -- a Xander Bogaerts homer in the seventh -- on two hits in 6 1/3 innings and struck out six. He walked two and hit a batter.

Rookie Konnor Griffin, Ryan O'Hearn and Henry Davis each had two hits for the Pirate, who erupted for five runs in the eighth off Adrian Morejon to cement their sixth win in the past seven games.

Miguel Andujar had the only other hit for San Diego, which had scored 13 runs over its previous two games. Nick Pivetta (1-2) gave up two runs over five innings.

Red Sox 3, Brewers 2

Trevor Story snapped a scoreless tie with a bases-loaded double in the sixth inning, Garrett Crochet took a shutout into the seventh and Boston held on for a victory over visiting Milwaukee.

The Red Sox, who managed just three hits, converted three consecutive walks into three runs in the sixth off Jacob Misiorowski (1-1) for a 3-0 lead. Crochet (2-1) allowed two runs on five hits in 6 1/3 innings. Aroldis Chapman finished with a scoreless ninth for his third save.

In the seventh, the Brewers scored a pair when David Hamilton was plunked and pinch hitter Christian Yelich bounced into a run-scoring groundout. Misiorowski, who struck out the first five batters he faced and finished with 11 K's, allowed three runs on two hits in 5 1/3 innings.

Guardians 2, Royals 1

Brayan Rocchio delivered a tiebreaking RBI single with one out in the bottom of the ninth inning, sending host Cleveland to a victory over Kansas City.

Rocchio was 0-for-3 until facing John Schreiber (0-1) with runners at first and second in the ninth, poking a single through the right side. Lane Thomas came up cleanly with Rocchio's hit but could not throw out CJ Kayfus at the plate.

Cade Smith (2-0) earned the victory, striking out two in a 1-2-3 ninth. Guardians pitchers limited the Royals to one hit, a solo home run by Carter Jensen in the second inning.

Orioles 4, White Sox 2

Gunnar Henderson hit a tiebreaking two-run home run in the eighth inning as visiting Baltimore rallied past Chicago.

Blaze Alexander and Taylor Ward hit back-to-back one-out doubles in the eighth as the Orioles tied the game off Jordan Hicks (0-1) before Henderson gave them their first lead with his fourth homer of the season. Trevor Rogers delivered six innings of two-run work for Baltimore, and Yennier Cano (1-1) recorded the win.

Chase Meidroth drove in a run and had two hits for the White Sox, who saw Shane Smith last just 3 2/3 scoreless innings in his start, striking out eight but walking five.

Mets 4, Diamondbacks 3 (10 innings)

Ronny Mauricio delivered the game-winning single in his first plate appearance for host New York, which beat Arizona in 10 innings.

Brett Baty and Jared Young each delivered a sacrifice fly and Francisco Alvarez scored on an error for the Mets, who extended their winning streak to four games. Luke Weaver (1-0) retired all three batters in the top of the 10th.

Adrian Del Castillo (two-run single) and Nolan Arenado (double) had RBI hits in the fifth for the Diamondbacks, who lost for the third time in five games. Paul Sewald (0-2) recorded just one out in the 10th.

Reds 6, Marlins 3 (10 innings)

Cincinnati -- scoreless against Sandy Alcantara until the ninth inning -- rallied to defeat host Miami. The Reds tied the score in the ninth on a two-out wild pitch by Anthony Bender, and they took control in the 10th on Nathaniel Lowe's go-ahead RBI single and Matt McLain's two-run double.

Alcantara allowed just three hits -- two singles and one double -- plus two walks and two runs in 8 1/3 innings, striking out six. Miami started the ninth with a 2-0 lead, and both runs were scored while Bender was on the mound.

Marlins center fielder Jakob Marsee, who entered the game batting just .105, went 2-for-4 with one walk, two runs and a career-high four stolen bases.

Cardinals 7, Nationals 6 (10 innings)

Thomas Saggese and JJ Wetherholt hit run-scoring doubles in the 10th inning and visiting St. Louis beat Washington.

Saggese led off with a double off Cole Henry (0-2) to score automatic runner Masyn Winn with the go-ahead run. With two outs, Wetherholt doubled to right, scoring Saggese to make it 7-5. Jordan Walker homered for the second straight night and Church also went deep for the Cardinals. Nolan Gorman had three hits.

James Wood homered for the third straight game for Washington, and Curtis Mead had three hits, including a home run.

Rangers 3, Mariners 2

Nathan Eovaldi pitched six quality innings and Kyle Higashioka hit a go-ahead home run, rallying Texas to a win over struggling Seattle in Arlington, Texas.

Eovaldi, making his 300th career major league start, picked up his first win of the season after two losses, allowing two runs on six hits with seven strikeouts and a pair of walks.

George Kirby (1-2) threw an eight-inning complete game for Seattle, which lost its fourth straight and its sixth in the past seven games.

Cubs 9, Rays 2

Javier Assad threw 5 2/3 scoreless innings and Pete Crow-Armstrong and Moises Ballesteros hit late-inning home runs to seal Chicago's win over Tampa Bay in St. Petersburg, Fla.

Seven Cubs, including Crow-Armstrong and Ballesteros, had two or more hits as part of a 16-hit output. Nico Hoerner went 2-for-4 with two RBIs. Assad (1-0), making his season debut after beginning the year in Triple-A Iowa, allowed just one hit and two walks.

Mason Englert (0-1) was a spot starter for Tampa Bay after Drew Rasmussen was a late scratch for personal reasons. Englert took the loss, giving up four runs (three earned) on seven hits in 3 2/3 innings.

Yankees 5, Athletics 3

Amed Rosario gave New York the lead by hitting a three-run home run, his second of the game, in the eighth inning as the Yankees downed the visiting Athletics.

Rosario also homered off A's starter Aaron Civale in the second inning for New York's first run. It was the veteran infielder's third career multi-homer game. New York starter Cam Schlittler allowed his first three runs of the season, all in the third inning, scattering five hits over five innings.

Nick Kurtz hit a two-run double and Tyler Soderstrom added an RBI double when the A's had four hits in the third and took a 3-1 lead. Civale allowed two hits and one run over five innings before former Yankee Mark Leiter Jr. (0-1) took the loss.

Rockies 5, Astros 1

Kyle Freeland pitched 6 1/3 strong innings, Willi Castro and Mickey Moniak homered and Colorado beat visiting Houston. Castro finished with three hits and three RBIs while TJ Rumfield singled twice for Colorado, which has won three in a row.

Freeland (1-1) became the first Rockies starter to pitch into the seventh inning this season. He allowed one run on three hits. Antonio Senzatela threw 2 2/3 perfect innings to pick up his first career save.

Christian Walker homered, one of just three hits for the Astros, who have lost three in a row. Mike Burrows (1-2) permitted three runs on eight hits in 5 1/3 innings.

Dodgers 4, Blue Jays 1

Yoshinobu Yamamoto pitched an effective six-plus innings and visiting Los Angeles defeated Toronto. Yamamoto (2-1) allowed one run, five hits and one walk with six strikeouts in his first appearance back in the stadium where he was named World Series MVP last year after closing out Game 7.

Alex Freeland had three hits for the Dodgers, who have won five in a row while the Blue Jays have lost six straight.

Los Angeles took a 2-0 lead in the third against Kevin Gausman (0-1), who opposed Yamamoto in Games 2 and 6 of the World Series. Gausman yielded three runs on five hits in 5 1/3 innings.

Twins 4, Tigers 2

Ryan Jeffers doubled and drove in a pair of runs as Minnesota held on for a win over Detroit in Minneapolis.

Luke Keaschall and Josh Bell added one RBI apiece for the Twins. Taj Bradley (2-0) continued his red-hot start to the season, limiting the Tigers to one run on six hits in 6 1/3 innings,

Detroit's Tarik Skubal (1-2) unraveled after four scoreless innings. He exited after giving up four runs on eight hits in 4 2/3 innings. Kevin McGonigle went 2-for-5 with a double and two RBIs.