Houston Astros shortstop Jeremy Pena is getting the day off on Saturday against the Los Angeles Angels at Daikin Park, according to MLB.com. Pena did not start on Opening Day on Thursday due to a fractured finger that he suffered earlier this spring while preparing for the World Baseball Classic, but he made his 2026 season debut in Friday night's loss and went 2-for-5 at the plate with a run scored and a stolen base. Veteran Carlos Correa will make another start at the 6 on Saturday, with Isaac Paredes starting at third base against Angels left-hander Reid Detmers. The 28-year-old Pena's performance on Friday was a good sign that his finger won't affect his production at the plate early in the season. Pena should be back in the starting lineup and at shortstop for the series finale against the Halos on Sunday. Correa has hit .222 with a homer and three RBI in nine career at-bats against Detmers, while Paredes has hit .333 against him with one RBI in six at-bats.

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With Texas Rangers right-hander Jacob deGrom (neck) scratched from his scheduled start on Saturday against the Philadelphia Phillies at Citizens Bank Park due to neck stiffness, left-hander Jacob Latz will make the spot start. The 29-year-old Latz was competing for a spot in Texas' starting rotation in spring training, but he lost out to former first-rounder Kamar Rocker. Latz made 33 appearances for the Rangers in 2025, including eight starts. In a career-high 85 2/3 innings pitched, he had a solid 2.84 ERA (3.72 FIP) and 1.24 WHIP with 76 strikeouts and 37 walks in 33 appearances. In his eight starts, he had a 2.72 ERA with 34 punchouts and 15 walks in 39 2/3 innings pitched. Latz is a decent fallback option for the Rangers for their first spot start of the season, but in DFS, fantasy managers will want to avoid him on the road in a hitter-friendly venue against a strong lineup.

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Milwaukee Brewers first baseman Andrew Vaughn (hand) fractured the left hamate bone in his hand on Opening Day on Thursday and will require surgery, according to Adam McCalvy of MLB.com. Vaughn is expected to need four to six weeks of recovery. The Brewers placed Vaughn on the 10-day injured list on Saturday. It's a tough break for the former White Sox first baseman, who came to life in Milwaukee after being acquired from Chicago last year. In 64 games with the Brew Crew, he hit .308/.375/.493 with an .869 OPS, nine home runs, 46 RBI, and 26 runs scored in 254 plate appearances. With Vaughn going on the IL, the Brewers recalled catching prospect Jeferson Quero. Veteran catcher Gary Sanchez figures to platoon at first base with Jake Bauers, while Quero gives starting catcher William Contreras a breather when he needs it behind the plate. In the Opening Day win on Thursday over his former team, the White Sox, Vaughn went 1-for-4 with an RBI.

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Texas Rangers right-hander Jacob deGrom (neck) said he woke up on Saturday with a stiff neck, which is why he was scratched from his scheduled outing in Philadelphia against the Phillies, according to Kennedi Landry of MLB.com. The Rangers decided not to push it with the oft-injured veteran, and deGrom feels "confident" that he'll make a start on the current road trip. It's good news for the Rangers and for fantasy managers, but it's also another reminder that it's hard to trust the 37-year-old veteran when it comes to durability. On the bright side, it's good news that it's not related to deGrom's arm. Jacob Latz will make the spot start on Saturday versus the Phillies. As of right now, deGrom is tentatively scheduled to start on Tuesday at Camden Yards against the Baltimore Orioles. He'll be more of a risky fantasy play in that matchup in his first start of the 2026 season if he makes it.

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Cincinnati Reds infield prospect Sal Stewart (forearm, wrist) is in the team's starting lineup on Saturday against the visiting Boston Red Sox and right-hander Sonny Gray despite dealing with a sore forearm from being hit by a line drive on Opening Day on Thursday, according to Gordon Wittenmyer of The Cincinnati Enquirer. He's starting at first base and batting in the cleanup spot. The 22-year-old came out of the gates strong on the plate on Thursday, going 3-for-4 with two doubles in the Opening Day loss to Boston. Between first base and designated hitter, Stewart should be a lineup regular for the Reds in his first full year in the majors in 2026, and he has plenty of slugging upside that will play in all fantasy formats, especially if he continues to hit in the heart of the batting order. The former first-rounder in 2022 went 14-for-55 (.255) with five home runs, eight RBI, and 11 runs scored in just 18 games last year in his big-league debut. Stewart is a big part of the Reds' future.

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Philadelphia Phillies right-hander Zack Wheeler (shoulder) will make his first minor-league rehab start with Triple-A Lehigh Valley on Saturday. Matt Gelb of The Athletic reports that Wheeler will make another rehab outing on Friday against Triple-A Durham, then another one at Double-A Reading. It's possible that Wheeler would make a fourth rehab outing after that, but it's not set in stone. Wheeler is scheduled to throw three innings and/or 50 pitches in his start on Saturday for the Iron Pigs. It's the first game action for the 35-year-old veteran since he underwent surgery for venous thoracic outlet syndrome in September. It's a unique surgery to come back from, which makes Wheeler more risky as a fantasy commodity in 2026, but all reports on his rehab have been very positive this spring. Before his injury in 2025, Wheeler was operating as a fantasy ace once again. Even though he carries more risk, Wheeler should be stashed in all formats, and he could make his season debut in April.

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Cincinnati Reds manager Terry Francona said that left-hander Nick Lodolo (finger) will throw a bullpen session on Sunday and could pitch in a minor-league rehab game on Wednesday, according to Charlie Goldsmith of FOX 19. Lodolo opened the 2026 regular season on the 15-day injured list due to a blister on his left index finger, but he's making good progress and should be ready to rejoin Cincy's starting rotation by mid-April, barring a setback once he starts his rehab assignment in the minors. The 28-year-old southpaw could push fellow lefty Brandon Williamson out of the Reds' starting rotation upon his return. Lodolo, a former first-round pick by the Reds in 2019 out of TCU, should be stashed in all fantasy baseball formats for his high-strikeout upside. Injuries have been an issue for the lefty, but when healthy, Lodolo has an above-average 26.2% strikeout rate in his four major-league seasons.

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Milwaukee Brewers first baseman Andrew Vaughn (hand) is battling a hand injury, per Adam McCalvy of MLB.com. McCalvy reports that Vaughn's injury is prompting Milwaukee to promote catching prospect Jefferson Quero to provide the team the flexibility to use normal backup catcher Gary Sanchez at first base. Vaughn appears likely to be placed on the injured list, but it's not entirely clear how much time Milwaukee expects him to miss. The 27-year-old started Milwaukee's opener on Thursday against the Chicago White Sox at first base and batted cleanup. Vaughn closed the 2025 season on a tear, hitting .308/.375/.493 with nine home runs, 46 RBI, and 26 runs scored across 254 plate appearances with Milwaukee. If he's forced to miss time, Sanchez and left-handed hitting outfielder/first baseman Jake Bauers could be the leading candidates to cover first base for the Brewers.

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Los Angeles Dodgers closer Edwin Diaz converted his first save chance with his new team on Friday night in the Dodgers' 5-4 win over the Arizona Diamondbacks. Diaz allowed a walk but struck out two without allowing a hit in a scoreless ninth inning. The 32-year-old signed a three-year, $69 million contract with Los Angeles this past winter after a six-season run with the New York Mets. Across 66 1/3 innings with New York in 2025, Diaz recorded a 1.63 ERA and a 0.87 WHIP with 98 strikeouts, six wins, and 28 saves. He's recorded a strikeout rate of at least 38% in six out of the last seven seasons where he's pitched. When healthy, Diaz is arguably the best closer in baseball and should get plenty of save chances while pitching for the Dodgers in 2026.

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Pittsburgh Pirates outfielder Oneil Cruz is not in the starting lineup for his team's matchup with the New York Mets and left-handed starting pitcher David Peterson on Saturday. Switch-hitter Jake Mangum will take Cruz's spot in center field and bat ninth. Cruz's 2026 season got off to a rough start in Pittsburgh's opener against the Mets on Thursday, as he struck out three times in five plate appearances and misplayed a ball in center field that led to multiple runs for New York. The 27-year-old owns a slash line of .172/.247/.313 with a 38.4% strikeout rate in 401 career plate appearances against left-handed pitching. It appears that Pittsburgh is planning to deploy Cruz in a true big-side platoon role in center field, at least to begin 2026. Cruz's power/speed profile makes him a high-upside fantasy outfielder, but his ability to rack up counting stats is limited by his lack of everyday playing time.

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Toronto Blue Jays third baseman Kazuma Okamoto has been moved up to the cleanup spot in his team's lineup for Toronto's matchup on Saturday against the Athletics and left-handed starting pitcher Jeffrey Springs. Okamoto batted seventh for the Blue Jays' opener on Friday with the A's throwing right-handed starting pitcher Luis Severino. Okamoto performed well in his MLB debut, going two-for-three with a walk and two runs scored. The 29-year-old is expected to play a key role as the Blue Jays' everyday third baseman in 2026 after the team brought him over from Japan on a four-year, $60 million contract. Okamoto's prominent spot in the lineup against left-handers should help him rack up counting stats for fantasy managers, and could be an indicator of his potential to move up in the lineup against righties if he proves he can handle MLB pitching.

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Texas Rangers ace Jacob deGrom (neck) has been scratched from his scheduled start on Saturday against the Philadelphia Phillies due to neck stiffness. Left-hander Jacob Latz will make the start in deGrom's place. After failing to reach 100 innings pitched in four consecutive seasons from 2021 through 2024 due to multiple different arm injuries, deGrom finally put together a healthy campaign in 2025. Across 172 2/3 innings (30 starts), the 37-year-old recorded a 12-8 record with a 2.97 ERA, 0.92 WHIP, and 185 strikeouts. On the bright side, deGrom's current issue is not arm-related, and he may simply need to be pushed back a few days before he can make his first start of 2026. However, any injury issue for deGrom is a concern for fantasy managers, given his extensive track record of missed time in recent years. Texas wraps up its series with the Phillies on Sunday before heading to Baltimore for a three-game set with the Orioles that begins on Monday evening.

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Washington Nationals shortstop CJ Abrams is currently away from the team due to the passing of a family member, per Mark Zuckerman of Nats Journal. Nationals infielder Nasim Nunez will fill in for Abrams at shortstop for the team's game on Saturday against the Chicago Cubs, with infielder Jorbit Vivas taking Nunez's regular spot at second base. Abrams went one-for-four with two RBI in Washington's Opening Day win on Thursday against the Cubs. It's not entirely clear how long Abrams will be away from the team, but it's unlikely to be an extended absence. The Nationals wrap up their series in Chicago on Sunday before traveling to Philadelphia for a three-game series that begins on Monday night.

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The Milwaukee Brewers are calling up catching prospect Jeferson Quero from Triple-A Nashville on Saturday, a source told Daniel Alvarez-Montes of ElExtra Base. Quero, the team's No. 8 prospect per MLB Pipeline, will give the Brewers more catching depth behind William Contreras and Gary Sanchez. The 23-year-old Venezuelan backstop will be making his big-league debut whenever he gets into a game, but right now, his path to playing time appears blocked in Milwaukee. Quero dealt with hamstring and shoulder injuries in the minors in 2025 and was limited to 250 plate appearances, hitting .255/.336/.412 with 11 home runs, 57 RBI, and 42 runs scored in 69 games on the farm. It's a questionable early-season call-up unless one of Contreras or Sanchez is currently dealing with an injury that we are unaware of. Quero is considered one of baseball's best defensive catching prospects, although he's not on MLB Pipeline's list of top-10 catching prospects overall.

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Miami Marlins right-handed closer Pete Fairbanks was successful in his first save opportunity on Opening Day on Friday, locking down the team's 2-1 victory over the visiting Colorado Rockies. In his inning of work, Fairbanks allowed a hit and struck out one batter to pick up his first win of the 2026 season with his new squad. The 32-year-old veteran signed a one-year, $13 million deal with the Fish over the winter to be their closer for this season, and if he can stay healthy, he'll have a good shot at his first career 30-save campaign in the big leagues. Fairbanks is in his eighth season in MLB and has 91 career saves with the Texas Rangers and Tampa Bay Rays. He had a 2.83 ERA, 1.04 WHIP, a career-high 27 saves, 59 strikeouts, and 18 walks in 60 1/3 innings in 2025 in his final year in Tampa. Despite being in Miami, Fairbanks should be a pretty stable fantasy closer, as he's had at least 20 saves in each of the last three seasons.

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Toronto Blue Jays infielder Andres Gimenez was the hero for the Blue Jays on Friday in their 3-2 Opening Day win over the visiting Athletics on Friday, driving home the winning run in the bottom of the ninth inning. Gimenez finished the game 2-for-3 with a two-run triple, an RBI single, and a walk out of the nine-hole. The 27-year-old, who is now playing shortstop for the Blue Jays with Bo Bichette no longer in town, has been riding high of late, also helping Team Venezuela win the World Baseball Classic this spring. Gimenez was an All-Star back in 2022 with the Cleveland Guardians and had 70 total stolen bases from 2022 to 2024, but he's still mostly useful to Toronto for his defensive prowess up the middle. He has a .254/.317/.383 career slash line in 670 career games, and has never reached the 20-home run mark. Offensive performances like Friday night will probably be few and far between for Gimenez, but his speed can be useful in deeper leagues.

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Cleveland Guardians outfield prospect Chase DeLauter is now up to three home runs on the year after just the first two games of the season after he homered again in the team's 5-1 loss to the Seattle Mariners on Friday night. DeLauter, batting in the two-hole for Cleveland, went 1-for-4 on the night with a solo home run and a strikeout. In his first two games of the 2026 season, the 24-year-old left-handed slugger has gone 4-for-9 with three home runs (all solo jobs). It's been nice to see from the former 16th overall pick in 2022 out of James Madison University in his first taste of major-league pitching. He also looked good at the plate this spring, batting .459/.535/.838 with a 1.373 OPS, three homers, five doubles, 10 RBI, 10 runs scored, six walks, and four strikeouts in 14 Cactus League games. Durability has been an issue for DeLauter in the minors, but for now, fantasy managers need to swoop him up where he's available, as he's looking like a potential early favorite for American League Rookie of the Year if he can stay on the field for Cleveland.

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St. Louis Cardinals catcher Ivan Herrera (knee) will bat second and play catcher for Saturday's contest against the Tampa Bay Rays. Herrera was the designated hitter for the Cardinals' regular-season opener on Thursday, but it appears that he's now healthy enough to get back into the defensive alignment. The 25-year-old is looking to build off a breakout 2025 campaign in which he slashed .284/.373/.464 with 19 home runs, 66 RBI, a 9.5% walk rate, an 18.6% strikeout rate, and 137 wRC+. He went 0-for-4 on Opening Day, but it's far too early to panic. He still has tremendous upside given his production at the plate and near-league-average defense. As it stands, he ranks #10 among catchers in RotoBaller's latest fantasy baseball rankings for 2026.

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Los Angeles Angels right-handed reliever Jordan Romano is emerging as the team's primary closer with all of Kirby Yates (knee), Ben Joyce (shoulder), and Robert Stephenson (elbow) on the injured list to begin the 2026 season. Romano picked up his first save of the year in Thursday's 3-0 Opening Day win over the Houston Astros, and although it wasn't a save situation, he pitched in the ninth inning for a second straight day in Friday's 6-2 victory. He had a clean inning of work to finish off the victory, striking out two batters. Romano had a rough couple of seasons the last few years, but he topped out at 95.7 mph on Friday and is looking more like the version of himself that had 36 saves in back-to-back years with the Toronto Blue Jays in 2022 and 2023. Veteran left-hander Drew Pomeranz could also see some save chances for the Halos early in the year with the back end of the bullpen banged up, but for now, Romano is the arm to roster for fantasy managers in need of saves.

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Houston Astros relief pitcher Bennett Sousa (oblique) has been diagnosed with a Grade 1 oblique strain, according to Chandler Rome of The Athletic. He was placed on the injured list but is not expected to miss more than the minimum 15 days. Sousa was a key part of the Astros' bullpen in 2025, posting a 2.72 FIP with 10.48 K/9, 2.66 BB/9, and 0.71 HR/9 over 50.2 innings of work. He also recorded four saves. Sousa didn't pitch in a 2026 regular-season game before landing on the IL, but he did throw three innings of one-run ball in spring training. Without consistent save opportunities, Sousa isn't on the fantasy radar. Still, Astros fans will patiently await his return to the bullpen, given how well he pitched last year.

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