

| PLAYER | POS | NFL | BYE | INJ | OPP | DATE | LINEUP | PTS | SCORING | |
|---|---|---|---|---|---|---|---|---|---|---|
| Bo Nix | QB | DEN | 12 | X | LAC | |||||
| Geno Smith | QB | LV | 8 | O | KC | |||||
| Chris Rodriguez Jr. | RB | WAS | 12 | @PHI | ||||||
| Jaylen Warren | RB | PIT | 5 | BAL | ||||||
| Tee Higgins | WR | CIN | 10 | CLE | ||||||
| Cooper Kupp | WR | SEA | 8 | @SF | ||||||
| George Pickens | WR | DAL | 10 | @NYG | ||||||
| Dalton Schultz | TE | HOU | 6 | IND | ||||||
| Brenton Strange | TE | JAX | 8 | TEN | ||||||
| Brock Purdy | QB | SF | 14 | SEA | ||||||
| DJ Giddens | RB | IND | 11 | @HOU | ||||||
| Alvin Kamara | RB | NO | 11 | O | @ATL | |||||
| Miles Sanders | RB | DAL | 10 | X | @NYG | |||||
| Zavier Scott | RB | MIN | 6 | GB | ||||||
| Jaylen Wright | RB | MIA | 12 | @NE | ||||||
| Jauan Jennings | WR | SF | 14 | SEA | ||||||
| Demarcus Robinson | WR | SF | 14 | SEA | ||||||
| Darius Slayton | WR | NYG | 14 | DAL | ||||||
| Mark Andrews | TE | BAL | 7 | @PIT | ||||||
| Isaiah Likely | TE | BAL | 7 | @PIT | ||||||
| Joe Mixon | RB | HOU | 6 | N | IND | |||||
| Brandon Aiyuk | WR | SF | 14 | U | SEA | |||||
| WEEK | SCORE | HIGH SCORER | OPPONENT | SCORE | RESULT | |||
|---|---|---|---|---|---|---|---|---|
| Week 1 | 81.65 102.35 | Geno Smith (22.10) Best Roster | vs | Don | 108.75 | LOSS | ||
| Week 2 | 138.70 140.60 | Bo Nix (23.30) Best Roster | vs | AZ Smashmouth SF1 | 141.00 | LOSS | ||
| Week 3 | 108.10 134.40 | Geno Smith (28.95) Best Roster | vs | BUMPKIN | 108.70 | LOSS WIN | ||
| Week 4 | 120.25 138.75 | George Pickens (33.40) Best Roster | vs | Grumpy Dawg | 146.40 | LOSS | ||
| Week 5 | 88.60 96.90 | Bo Nix (20.30) Best Roster | vs | The Heavyweights | 176.75 | LOSS | ||
| Week 6 | 103.70 115.70 | George Pickens (31.80) Best Roster | vs | Washington | 164.20 | LOSS | ||
| Week 7 | 127.70 138.80 | Bo Nix (42.75) Best Roster | vs | Mr Griddys Naberhood Watch | 132.20 | LOSS WIN | ||
| Week 8 | 93.15 93.35 | Bo Nix (27.35) Best Roster | vs | Brahma Bulls | 141.25 | LOSS | ||
| Week 9 | 147.85 172.35 | Tee Higgins (33.10) Best Roster | vs | TPE | 160.05 | LOSS WIN | ||
| Week 10 | 108.05 111.80 | Dalton Schultz (18.30) Best Roster | vs | HouseTimmins | 211.20 | LOSS | ||
| Week 11 | 117.95 137.40 | George Pickens (29.40) Best Roster | vs | +Fever'S Break | 118.65 | LOSS WIN | ||
| Week 12 | 103.00 118.10 | George Pickens (29.60) Best Roster | vs | Don | 124.50 | LOSS | ||
| Week 13 | 132.75 133.75 | Bo Nix (20.65) Best Roster | vs | AZ Smashmouth SF1 | 135.00 | LOSS | ||
| Week 14 | 107.00 125.80 | Tee Higgins (27.20) Best Roster | vs | BUMPKIN | 100.90 | WIN | ||
| Playoff Week 1 | 81.00 | Bo Nix (32.10) | -- No Game Scheduled -- | |||||
| Playoff Week 2 | 158.35 186.35 | Brock Purdy (34.85) Best Roster | vs | Mr Griddys Naberhood Watch | 80.90 | WIN | ||
| Playoff Week 3 | 76.20 124.35 | Brock Purdy (40.95) Best Roster | vs | AZ Smashmouth SF1 | 121.30 | LOSS WIN | ||
| Acquired | Zavier Scott RB MIN | Waiver Wire ($113) | Week 5 | Thu Oct 2 12:08am ET |
| Acquired | Dalton Schultz TE HOU | Waiver Wire ($39) | Week 5 | Thu Oct 2 12:08am ET |
| Released | Jack Bech WR LV | Waiver Wire | Week 5 | Thu Oct 2 12:08am ET |
| Released | Devin Neal RB NO | Waiver Wire | Week 5 | Thu Oct 2 12:08am ET |
| Acquired | Chris Rodriguez Jr. RB WAS | Waiver Wire ($43) | Week 1 | Sun Sep 7 12:04am ET |
| Released | Aidan O'Connell QB LV | Waiver Wire | Week 1 | Sun Sep 7 12:04am ET |
| On I/R | Brandon Aiyuk WR SF | Owner | Week 1 | Tue Aug 12 5:20pm ET |
| On I/R | Joe Mixon RB HOU | Owner | Week 1 | Tue Aug 12 5:20pm ET |
| Released | Jalen Coker WR CAR | Owner | Week 1 | Tue Jul 1 8:46am ET |
| Released | Gus Edwards RB --- | Owner | Week 1 | Tue Jul 1 8:46am ET |
| Released | Ameer Abdullah RB IND | Owner | Week 1 | Tue Jul 1 8:46am ET |
| Released | Juwan Johnson TE NO | Owner | Week 1 | Tue Jul 1 8:45am ET |
| Released | Ja'Lynn Polk WR NO | Owner | Week 1 | Tue Jul 1 8:45am ET |
| Released | Sean Tucker RB TB | Owner | Week 1 | Tue Jul 1 8:45am ET |
| Released | Keaton Mitchell RB BAL | Owner | Week 1 | Tue Jul 1 8:45am ET |