San Francisco 49ers quarterback Mac Jones was handed his first loss of 2025 when the team stumbled against the Buccaneers in Week 6. Jones went 27-for-39 for 347 yards in the game, with two interceptions. It was his first start in 2025 without a touchdown, as well. Jones is now 3-1 while standing in for Brock Purdy (toe) and leads the league with 313 passing yards per game, all while missing tight end George Kittle (hamstring) and the availability of wide receivers Ricky Pearsall (knee) and Jauan Jennings (ankle, ribs) in flux. Purdy will be evaluated during the team's first practice on Wednesday as a first step in determining his availability for Week 7. If he cannot go, Jones would be under center again, this time against an Atlanta Falcons defense that has yet to allow more than 180 passing yards in a game.

From RotoBaller

New England Patriots wide receiver DeMario Douglas endured an underwhelming start to the 2025 season, but he broke out in a huge way with three catches, 71 yards, and a touchdown on Sunday. He scored a 53-yard touchdown and also would have had a 61-yard score, but it was called back due to a teammate's penalty. Douglas has typically been a short-yardage outlet in the slot before, so it was intriguing to see him catch multiple deep passes on Sunday afternoon. It may be tempting to jump aboard the Douglas hype train after one big week, but we can't ignore how underwhelming he was during the first five games. Over that five-week span, he had just seven catches for 30 yards. He may have low-end streaming appeal in deep leagues, but for the most part, managers should monitor Douglas without rushing to add him off waivers quite yet.

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Los Angeles Rams quarterback Matthew Stafford posted disappointing fantasy results in Week 6, largely due to the extreme positive game script against the Baltimore Ravens. Los Angeles won the game by running the ball and draining the clock, which meant Stafford didn't have to throw the ball much. He also suffered from the brief exit of teammate Puka Nacua (ankle), who didn't like his normal self even when he returned. While Nacua could be sidelined against the Jacksonville Jaguars in Week 7, Stafford is still a strong candidate to bounce back in a game that should feature more of a neutral game script. The veteran lacks rushing upside but is still the overall QB10 in fantasy football this season. He should be rostered in all leagues at this point, so if he's still available on waivers, add him before it's too late.

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New England Patriots wide receiver Kayshon Boutte has returned to the fantasy radar after his impressive outing against the New Orleans Saints in Week 6. The third-year LSU product caught all five of his targets for 93 yards and two touchdowns, taking advantage of a favorable matchup against a secondary ranking at the bottom of the league when covering perimeter receivers. While Boutte may not see another matchup as favorable for the rest of the season, Sunday's outing still has him trending upward ahead of Week 7. Boutte may be the Patriots' top scoring threat in the receiving game, and he offers the most explosiveness as a big-play option deep downfield. In addition to being a solid waiver wire option for the rest of the season, he also has short-term streaming appeal against a Titans defense allowing the eighth-most fantasy points to wide receivers in 2025.

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Los Angeles Rams wide receiver Davante Adams could take on an expanded role going forward, starting with Sunday's Week 7 contest against the Jacksonville Jaguars in London. There will be additional targets to go around with Puka Nacua (ankle) expected to miss the international game. It's unclear exactly how much time Nacua will miss, and while it's not expected to be a long-term injury, Adams should handle a significant portion of Nacua's vacated targets for at least a week or two. This is encouraging news for the veteran receiver and his fantasy managers. Adams has been able to maintain WR2 value in fantasy football, but his mere 47.3 percent catch rate has been disappointing, to say the least. An increased target share should at least lead to more catches for Adams in Week 7, if not a higher catch rate. He'll sneak into the low-end WR1 tier as soon as Nacua is ruled out.

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Arizona Cardinals veteran quarterback Jacoby Brissett led the offense to their most productive game of the season in their Week 6 loss at Indianapolis. Brissett completed 27 of 44 passes for 320 yards, two touchdowns, and an interception. The 320 passing yards and 400 total yards were both season highs for Arizona. When asked why the offense looked so different against the Colts, Gannon said they "tailored the scheme a little bit" during the week in case Brissett ended up starting. The coaching staff made a few adjustments to their base offense to help Brissett feel more comfortable, and the results were encouraging. With Kyler Murray still dealing with a mid-foot sprain, we may see Brissett make a few starts. He could make for a solid add in superflex and two-quarterback leagues.

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Los Angeles Rams tight end Tyler Higbee had his best game of the season in Week 6 against Baltimore, catching all four of his targets for 40 yards and a touchdown. Higbee played 66% of snaps in the game, his highest since Week 2 at Tennessee, where he saw 75.4% of snaps and caught all four of his targets for 37 yards. The veteran tight end finished tied second on the team in targets after Puka Nacua (ankle) left early with an injury. He'll be a waiver wire option this week for fantasy managers in need of a tight end, especially with Nacua expected to miss some time and opportunities opening up.

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Veteran quarterback Joe Flacco posted a solid performance in his first game as the starter for the Cincinnati Bengals in Week 6. After being acquired by Cincinnati from the Cleveland Browns early last week, Flacco completed 29 of 46 pass attempts for 219 yards, two touchdowns, and zero interceptions in a difficult matchup against the Green Bay Packers. The 40-year-old will have another short week of preparation in Week 7 as Cincinnati will take on the Pittsburgh Steelers on Thursday night. Flacco's propensity for high passing volume, coupled with the Bengals' elite-level talent at the wide receiver position, gives the veteran signal-caller some fantasy appeal in two-quarterback formats.

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Tennessee Titans rookie wide receiver Elic Ayomanor has recorded 17 catches for 196 yards and two touchdowns on 34 targets through the first six games of his career. While the 22-year-old has yet to have a signature breakout game, Ayomanor has been a consistent feature in the Titans' offense and has earned at least five targets in five out of six games. With veteran Titans wideout Calvin Ridley (hamstring) potentially facing missed time due to a hamstring injury, Ayomanor could be poised to take over as the team's WR1 in Week 7 against the New England Patriots. Tennessee's anemic offense caps Ayomanor's upside, but he should still be rostered in most fantasy leagues and could be a deep-league flex option in Week 7.

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New York Jets wide receiver Allen Lazard has recorded just four catches for 24 yards on six targets across four games so far this season. Still, Lazard could have a chance to make his mark in New York now that star Jets wideout Garrett Wilson (knee) is facing a multi-week absence due to a knee injury. Lazard missed the team's Week 6 matchup against the Denver Broncos due to personal reasons, so his status for Week 7 is somewhat unclear. If he's able to return to the lineup in Week 7, Lazard could be the favorite to start at wide receiver for the Jets alongside fellow veteran Josh Reynolds in a favorable matchup against the Carolina Panthers. In the very deepest of fantasy leagues, Lazard could be a short-term desperation flex option while Wilson is sidelined.

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New York Giants wide receiver Lil'Jordan Humphrey made his 2025 season debut in Week 6 against the Philadelphia Eagles, recording four catches for 55 yards on eight targets. With the Giants missing wideouts Malik Nabers (knee) and Darius Slayton (hamstring), Humphrey stepped up and led the team in targets. Nabers is out for the season, and Slayton's status for Week 7 is unclear, so Humphrey could be set up for another game where he plays a prominent role in the team's passing game. Still, the Giants have a very difficult matchup in Week 7 against the Denver Broncos, which limits Humphrey's waiver-wire appeal. He's a name to monitor on the waiver wire, but Humphrey could also fade back to fantasy irrelevance as soon as Slayton returns to the lineup.

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Pittsburgh Steelers tight end Jonnu Smith logged just three catches for 18 yards on four targets in a 23-9 win over the Cleveland Browns. Coming out of a Week 5 bye, it was fair to wonder if Pittsburgh would try to get Smith more involved in its offense after acquiring him over the summer. Unfortunately, Smith once again played behind Darnell Washington, who has proven to be an effective run blocker. If Smith is going to turn things around, Thursday night's matchup against the Cincinnati Bengals is the ideal spot for him to do so. The Bengals have surrendered the most fantasy points per game to tight ends this season. Still, given his lack of opportunities recently, Smith can only be viewed as a dart-throw TE2.

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Arizona Cardinals wide receiver Zay Jones had by far his most productive game of the season in Week 6 against the Indianapolis Colts, recording five catches for 79 yards on eight targets. Jones had hauled in just five catches for 37 yards on seven targets across four games heading into Week 6. The 30-year-old's production against Indianapolis was buoyed by the absence of Marvin Harrison Jr. (concussion), who exited Week 6 early due to a concussion. With Harrison Jr.'s status for Week 7 against the Green Bay Packers in question, Jones could once again be called upon to play a larger role in his team's offense. Pending Harrison Jr.'s availability, Jones could be a deep-league waiver wire option as a short-term fill-in at the wide receiver position.

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Chicago Bears tight end Cole Kmet had a very quiet game in Week 6 against the Washington Commanders, recording one catch for zero yards on two targets. With fellow Bears tight end Colston Loveland sidelined by a hip injury, Kmet saw a brief target spike (nine) in Week 4. However, with Loveland back in the lineup against Washington after Chicago's Week 5 bye, it appears Kmet will have a hard time earning the target volume needed for consistent fantasy production. Through five games this season, Kmet has eight catches for 116 yards and one touchdown on 18 targets. He should remain off of fantasy radars unless Loveland were to go down with another injury.

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Dynasty | Jets wide receiver Garrett Wilson will miss time with a knee injury. Dynasty Analysis: While this doesn't seem like something that's going to end his season or end up being some kind of a long-term ailment, it could be a death blow to a Jets team that can't score. Wilson will apparently have an MRI but is likely to miss "a few weeks." Dynasty managers have to hope he somehow gets out of New York at some point in his career because his value is simply capped while playing with a franchise that can't seem to get things together. Wilson could be a decent trade target while he's out but his high floor and low ceiling is looking less and less desirable by the week.

From Dynasty League Fantasy

Pittsburgh Steelers running back Jaylen Warren handled 11 carries for 52 yards and hauled in both of his targets for 11 yards in a Week 6 win over the Cleveland Browns. Although he split touches with Kenneth Gainwell, Warren was the more efficient runner and led the RB room in snaps. This is encouraging for Warren's fantasy outlook heading into a Week 7 divisional showdown with the Cincinnati Bengals. The Bengals have surrendered the most fantasy points to opposing running backs this season, proving vulnerable both on the ground and through the air to the position. Fantasy managers should fire up Warren as an RB2 in all formats on Thursday night.

From RotoBaller

Pittsburgh Steelers tight end Darnell Washington came down with three of his five targets for 62 yards in a Week 6 victory against the Cleveland Browns. While it marked the second straight contest in which Washington led Pittsburgh's tight end room in snaps, it was his first time besting both Jonnu Smith and Pat Freiermuth in targets this season. Given how well the Steelers have operated offensively lately, Washington should remain involved in a Week 7 divisional clash against the Cincinnati Bengals. He hasn't done quite enough yet to warrant consideration in fantasy lineups, but Washington is trending positively and will be a name to watch on Thursday night.

From RotoBaller

Pittsburgh Steelers quarterback Aaron Rodgers completed 21 of his 30 pass attempts for 235 yards and two touchdowns in a 23-9 victory over the Cleveland Browns. It was his best fantasy showing since the season opener, in which he threw four touchdown passes. Though fantasy managers can't expect Rodgers to be a steady starting option, they can consider deploying him in Week 7 against the Cincinnati Bengals. Through six weeks, the Bengals are one of three NFL teams surrendering over 30 points per contest. Rodgers has serious upside on Thursday night and can be treated as a QB2 or streaming candidate.

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Chicago Bears WR DJ Moore (groin) is considered day-to-day, according to head coach Ben Johnson. Moore stayed overnight Monday at a Washington DC hospital to receive treatment for a groin injury.

Fantasy Spin: On the field, Moore has slid into a supporting role this year, pushing him down the fantasy rankings from a WR2, where he began the season, to what's now more of a WR4.

From TheHuddle

Veteran free-agent quarterback Brett Rypien signed with the Indianapolis Colts' practice squad on Tuesday, a source told Tom Pelissero of NFL Network. Anthony Richardson Sr. (eye) suffered a fractured orbital bone before Sunday's win over the Arizona Cardinals when a resistance band snapped and hit him in the face. With Richardson expected to be out multiple weeks, the Colts placed him on Injured Reserve on Monday, meaning he will be out at least four games. Rypien will give the Colts added QB insurance behind starter Daniel Jones and new No. 2 Riley Leonard. The 29-year-old was with the Minnesota Vikings in training camp before joining the Cincinnati Bengals. He played three offensive snaps with Cincy but was cut after the Bengals acquired veteran QB Joe Flacco in a trade. Rypien has completed 58.3% of his pass attempts for 950 passing yards, four touchdowns, and nine interceptions in 11 career games (four starts) since entering the league in 2020 with the Denver Broncos.

From RotoBaller