Kansas City Chiefs head trainer Rick Burkholder said that quarterback Patrick Mahomes (knee) was operated on quickly to fix the LCL part of his ACL/LCL knee injury that he suffered in Sunday's loss to the Los Angeles Chargers, according to Jesse Newell of The Athletic. Mahomes has started his rehab in Dallas this week and will continue through Thursday before returning to KC. The fact that the 30-year-old tore both his ACL and LCL will make his recovery more complicated, but reports suggest that Mahomes is "hellbent" on returning for the Week 1 season opener in 2026. For the final three weeks of the 2025 season, Gardner Minshew will run KC's offense, which is an obvious downgrade for all of the Chiefs' offensive skill players. Mahomes, a three-time Super Bowl MVP, threw for 3,587 yards, 22 touchdowns, and 11 interceptions in 14 games in 2025 in his ninth NFL season.

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Kansas City Chiefs wide receiver Tyquan Thornton (concussion) will not practice on Wednesday, according to head coach Andy Reid. Fellow wideout Rashee Rice is also dealing with a concussion and will not practice on Wednesday. The Chiefs have been eliminated from playoff contention and lost star quarterback Patrick Mahomes (knee) to a torn ACL in Sunday's loss to the Los Angeles Chargers, so they won't be pushing Thornton or Rice to play in Week 16 against the Tennessee Titans this Sunday. The 25-year-old Thornton has 19 catches on 36 targets for 438 yards and three touchdowns this year, but he's mostly been quiet in KC's offense since Rice returned from his suspension. He hasn't scored a touchdown since Sept. 28 and has five zero-catch games this year. If Thornton and Rice are unable to play this weekend, Xavier Worthy, Marquise Brown, and JuJu Smith-Schuster would all be forced into bigger roles.

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The Kansas City Chiefs say that wide receiver Rashee Rice (concussion) will not practice on Wednesday, according to Pete Sweeney. It's a new injury for Rice, and one that could certainly keep him from playing in the Week 16 game against the Tennessee Titans this Sunday, especially with the Chiefs now eliminated from playoff contention. The 25-year-old's fantasy stock will be down, regardless, for the final three games of the season, with quarterback Patrick Mahomes (knee) done for the year following a torn ACL suffered in Sunday's loss to the Los Angeles Chargers. Fantasy managers will want to keep a close eye on Rice's status the rest of the week. He'll need to gain clearance from an independent neurologist to play this Sunday. Tyquan Thornton also suffered a head injury against the Chargers. Xavier Worthy, Marquise Brown, and JuJu Smith-Schuster could be in for expanded roles against the Titans if Rice and Thornton are unable to suit up.

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The Buffalo Bills are opening wide receiver Mecole Hardman's (calf) 21-day practice window on Wednesday, according to Maddy Glab of BuffaloBills.com. Hardman has been on Injured Reserve for the last four games after injuring his calf in the Week 11 win over the Tampa Bay Buccaneers. The 27-year-old will be eligible to play this Sunday in Week 16 against the Cleveland Browns on the road, but the Bills will have to officially activate him from IR first. When healthy, Hardman is unlikely to be a big part of Buffalo's offense, especially with Gabe Davis and Brandin Cooks now in the picture. The former Kansas City Chiefs wideout will be a top kickoff return option on special teams, though. Hardman failed to reel in his only target in his only game played for the Bills this year. He will not be on the fantasy radar for the final three weeks of the regular season.

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Green Bay Packers head coach Matt LaFleur said that wide receiver Christian Watson (chest) is expected to be limited in Wednesday's practice, according to Rob Demovsky of ESPN. "He's improving. We'll just see how he's feeling out there," LaFleur said. Watson was listed as a non-participant on Tuesday's estimated injury report. He was hospitalized following a chest injury in Sunday's loss to the Denver Broncos, but doctors ruled out a long-term injury. The 26-year-old's status is up in the air for Saturday's big divisional rematch against the Chicago Bears, but it's a good sign that Watson is returning to practice. Since making his season debut halfway through the 2025 season, Watson has been Green Bay's go-to wideout, catching 28 of his 43 targets for 481 yards and five touchdowns. The former second-rounder had 89 yards and two touchdowns two weeks ago against Chicago. If he's cleared to play, Watson will have WR2 upside in the rematch in the Windy City.

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Arizona Cardinals head coach Jonathan Gannon said that wide receiver Marvin Harrison Jr. (heel) will take part in the team's walkthrough practice on Wednesday, per Tyler Drake of Arizona Sports. Harrison has missed the last two games with a heel injury, but Gannon said he's doing "good." The 23-year-old former first-rounder is expected to play again this year, possibly as soon as this Sunday against the Atlanta Falcons in Week 16. Harrison has missed four of the last five games with his heel injury, and after undergoing an appendectomy. The Ohio State product has not lived up to his fourth overall draft slot through almost two full NFL seasons. When healthy in 2025, Harrison has been inconsistent with 40 catches, 594 yards, and four touchdowns in 10 games. If Harrison returns this weekend, though, he'll be on the WR2 radar in Arizona's pass-happy offense. We'll continue to keep a close eye on his status over the next two days.

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Across seven games before his team's Week 8 bye, Detroit Lions wide receiver Jameson Williams had recorded just 17 receptions and looked like he was headed towards a disappointing year. However, the 24-year-old has had a breakout second half of the 2025 season and is now up to 52 receptions for 936 yards and seven touchdowns on 81 targets across 14 games. Over his last three games in particular, Williams has been dominant, hauling in 21 catches for 374 yards and two touchdowns on 28 targets. With Lions tight end Sam LaPorta (back) on Injured Reserve, Williams has emerged as the clear number two option in the Detroit passing game. With their defense struggling, the Lions have also been forced into more pass-heavy game scripts, leading quarterback Jared Goff to average 36 pass attempts per game over the last five contests. Between LaPorta's injury and Detroit's tendency to find itself in shootouts, Williams should see plenty more opportunities for production heading into matchups against the Pittsburgh Steelers and Minnesota Vikings over the next two weeks.

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Atlanta Falcons head coach Raheem Morris said that wide receiver Drake London (knee), who is considered day-to-day, will practice on Wednesday so the team can see where he's at, according to Terrin Waack of AtlantaFalcons.com. Morris said on Monday that he's "very hopeful" that London will return in Week 16 against the Arizona Cardinals. Wednesday will be the first time that the 24-year-old has practiced since spraining his left PCL back in Week 11. He's not a lock to play on Sunday against Arizona, but his return to practice at least gives his fantasy managers hope that he might be available this weekend. Tight end Kyle Pitts Sr. has had a much higher ceiling with London out, as evidenced by his monster 11-catch, 166-yard, three-touchdown spectacle last Thursday night. London is typically a must-start WR1 in fantasy when he's active, but he'll be a bit more volatile in Week 16 if he returns and is on a snap count.

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Making his first start since January 2021, Indianapolis Colts quarterback Philip Rivers managed to hold his own in Week 15 against the Seattle Seahawks. The 44-year-old completed 18 of 27 pass attempts for 120 yards, one touchdown, and one interception, and nearly led his team to an upset victory on the road. The Colts announced that Rivers will make another start in Week 16 against the San Francisco 49ers, who are expected to be a more manageable matchup than Seattle. Fantasy expectations should remain limited for Rivers, as he provides zero value as a rusher and averaged just 4.4 yards per pass attempt against the Seahawks. However, Rivers may be more productive as he gains more time to work with the Colts' pass catchers and becomes more familiar with the team's offense. In deep, two-quarterback fantasy leagues, Rivers could be a streaming option off the waiver wire in Week 16.

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Detroit Lions running back David Montgomery has seen a reduced workload in 2025 as fellow Lions back Jahmyr Gibbs has emerged as the team's clear lead rusher. However, Montgomery remains a red zone and goal-line threat, as he's scored a touchdown in three straight weeks and has eight scores on the season. The 28-year-old is still an effective rusher when given the opportunity, as he's averaging a career-best 4.7 yards per carry and has totaled 635 rushing yards across 14 games this season. Montgomery's ceiling is capped as long as Gibbs is healthy, as he's recorded double-digit touches just once over the last five weeks. Still, as a touchdown-dependent flex option, Montgomery has some fantasy value heading into his Week 16 matchup against the Pittsburgh Steelers and Week 17 matchup against the Minnesota Vikings.

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In a clip from HBO's "Hard Knocks: In Season with the NFC East," Washington Commanders head coach Dan Quinn is seen emphasizing the importance of hitting New York Giants quarterback Jaxson Dart when Dart takes off as a runner. Based on the clip, Giants beat writer Dan Duggan of The Athletic speculates that Dart "clearly has a target on his back as a runner." The rookie quarterback has been highly effective with his legs so far this season, recording 400 rushing yards and seven touchdowns across 11 games (nine starts). However, he also missed two games due to a concussion and has drawn criticism for his tendency to absorb unnecessary contact. If the 2-12 Giants pull back the reins on Dart as a rusher, his fantasy production would clearly be impacted. While Dart has shown little indication of being hesitant to run so far this season, it's a storyline worth monitoring as the team prepares to take on the Minnesota Vikings in Week 16.

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Cleveland Browns running back Dylan Sampson (hand) is not expected to practice on Wednesday, per Mary Kay Cabot of Cleveland.com. Sampson missed his team's Week 15 loss to the Chicago Bears due to both calf and hand injuries, but it appears it's the hand that's now giving him more problems. Across 13 games this season, the 21-year-old has recorded 375 scrimmage yards and two touchdowns on 72 touches. He's emerged as the primary receiving back in Cleveland, with fellow rookie running back Quinshon Judkins handling the lion's share of early-down work. With Sampson sidelined in Week 15, Trayveon Williams was utilized as Cleveland's RB2, recording seven yards from scrimmage on three touches. If Sampson remains sidelined for the Browns' Week 16 matchup against the Buffalo Bills, Judkins could see a significant workload as both a rusher and receiver.

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Cleveland Browns tight end David Njoku (knee) is not expected to practice on Wednesday, per Mary Kay Cabot of Cleveland.com. Njoku is battling a knee injury that forced him to miss Cleveland's Week 15 loss to the Chicago Bears. Across 12 games this season, the 29-year-old has hauled in 33 receptions for 293 yards and four touchdowns on 48 targets. If Njoku is sidelined for a second straight game in Week 16 against the Buffalo Bills, Browns rookie tight end Harold Fannin Jr. could continue his recent surge. Over the past two weeks, Fannin Jr. has recorded 15 receptions on 25 targets and appears to be emerging as the favorite pass-catcher of Browns quarterback Shedeur Sanders.

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Jacksonville Jaguars running back Travis Etienne Jr. exploded for three receiving touchdowns in the Week 15 blowout win over the New York Jets. Etienne added 12 carries for 32 yards and three catches for 73 yards on four targets in the game. The 26-year-old continued his breakout campaign, becoming the eighth player this season and the first running back with three receiving scores. Etienne entered the game with only three career receiving touchdowns, but he doubled that mark on Sunday. There have only been four other running backs to record three touchdown catches in a game since 2015. Despite averaging just 3.0 yards per carry over the last three games, Etienne has totalled the fourth-most PPR points among running backs (57.8) during that stretch. He is firmly entrenched as one of the best weekly running back options in fantasy, even in a tough Week 16 matchup against the Denver Broncos.

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Chicago Bears running back D'Andre Swift has enjoyed a bounce-back season in his second year with the team, compiling 191 carries for 935 yards and seven touchdowns to go with 29 receptions for 254 yards and another score on 41 targets. Swift has maintained a slight upper hand on the touches over rookie Kyle Monangai in the Bears' backfield lately, and notched his first two-touchdown game of the season in the Week 15 win over the Cleveland Browns. The 26-year-old back has been one of the most reliable weapons in an explosive Chicago offense all season, missing just one game. He's posted double-digit touches in all but one game, including at least 15 touches in all but two contests. Swift remains a must-start in fantasy football lineups, but he will have a tougher matchup in Week 16 against the division-rival Green Bay Packers this Saturday night.

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Arizona Cardinals running back Michael Carter is set to lead the backfield following Bam Knight (ankle) being placed on Injured Reserve. The Cardinals' backfield has been ravaged by injuries this season, and now Carter is the next man up. The 26-year-old played 53 of 66 snaps in the Week 15 loss to the Houston Texans, recording 14 carries for 56 yards while adding four receptions (four targets) for 38 yards as a receiver. Emari Demercado returned after missing the past three games with an ankle injury, but he wasn't very involved, playing just seven offensive snaps with three touches. Carter is expected to be the every-down back with Knight out of the picture, as he handled 78% of the running back rushing attempts and ran 72% of the routes in his absence. Carter had one game earlier this season with a similar workload back in Week 5, where he was inefficient as a runner with 18 carries for 51 yards, but found the end zone and added five catches (five targets) for 22 yards, finishing with 18.3 PPR points. Carter profiles as a top waiver-wire pickup this week and can be immediately plugged into lineups as an RB3/flex in Week 16 against the Atlanta Falcons.

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After being eliminated from the playoffs in Week 15, the Miami Dolphins have released veteran pass-rusher Matthew Judon, according to NFL Network's Mike Garafolo. The Dolphins granted his wish as he looks to join a contending team for the remainder of the 2025 season. Judon has played in 13 games this season and has yet to record a sack despite playing 41% of the snaps. Judon will likely look to clear waivers first before signing with the team of his choice, but keep an eye out for one of his former teams to be in the market, such as the Baltimore Ravens or New England Patriots. The Dolphins will hope that second-year pass rusher Chop Robinson will step up to replace the veteran.

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Denver Broncos rookie running back R.J. Harvey (rib) has found the end zone four times over the past three games, bringing his season total to 10 touchdowns. The rookie second-rounder is currently dealing with a rib injury he suffered late in the Week 15 win over the Green Bay Packers. The severity of the injury is unknown, but the Broncos did claim RB Cody Schrader off waivers on Tuesday, so fantasy managers will want to keep a close eye on Harvey's status in practice this week. Harvey has recorded at least 14 touches in four games since taking over as Denver's lead back with J.K. Dobbins (foot) on Injured Reserve. He's been one of the most productive running backs in fantasy football with the increased workload, ranking as the RB6 in PPR points per game at 18.6 over that stretch. Assuming he is healthy, Harvey will project as a solid RB1 again in Week 16 against the Jacksonville Jaguars. If Harvey is held out or is limited, Jaleel McLaughlin would step in to handle most of the early down work, with Tyler Badie working on passing downs.

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Washington Commanders rookie running back Jacory Croskey-Merritt operated as the team's lead runner in Week 15, with Chris Rodriguez Jr. (groin) ruled out with a groin injury. Croskey-Merritt delivered a strong performance, handling 18 carries for 96 yards and a touchdown in Washington's win over the New York Giants. Jeremy McNichols actually drew the start for Washington, but JCM ended up doubling him in carries. The rookie seventh-rounder found the end zone for the first time since his breakout performance in Week 5 against the Los Angeles Chargers, where he totalled 150 yards and two touchdowns. JCM looked decisive and explosive against the Giants, who notably have one of the worst run defenses in the league, but it was great to see the rookie deliver for fantasy managers who plugged him into their lineups for the first round of the fantasy playoffs. Croskey-Merritt could potentially work himself back into a more significant timeshare with McNichols and Rodriguez upon his return, creating a messy situation to sort through. He remains worth rostering and would project favorably again on Saturday against the Philadelphia Eagles if Rodriguez is out again on a short week.

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The Miami Dolphins are benching quarterback Tua Tagovailoa for rookie quarterback Quinn Ewers in Week 16, according to NFL Network's Ian Rapoport. After struggling in Week 15 against the Pittsburgh Steelers, head coach Mike McDaniel mentioned the idea of making a change at quarterback, stating, "all options are on the table." Tagovailoa is benched after having a career-worst season, leading the NFL in interceptions (15) and ranking near the bottom of the league in QBR (88.5). The former first-round pick received a massive contract extension that will make it difficult for him to be traded during the offseason. This is a situation to monitor closely as free agency approaches, while fantasy managers can safely drop Tagovailoa in all leagues.

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