Minnesota Vikings quarterback Carson Wentz led a come-from-behind victory Sunday against Cleveland, completing 25 of 34 passes for 236 yards and the game-winning touchdown, a 12-yard connection to Jordan Addison that concluded an 80-yard drive. Crucially, the veteran played a clean game Sunday with no turnovers. Wentz briefly departed after taking a shot to his non-throwing shoulder, but returned and played the entire second half without issue. His fantasy value is in flux, however, as Minnesota will have its bye in Week 6 and could see the return of starter J.J. McCarthy (ankle) in Week 7. The Vikings went 2-1 in Wentz's starts, but he'll likely return to his backup role when McCarthy is ready to play again.

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Cleveland Browns rookie running back Quinshon Judkins was his team's star of the show Sunday in a loss to Minnesota, compiling 128 total yards with a feature back's workload. The rookie from Ohio State drew 23 carries for 110 yards, caught one of two targets for another 18, and was by far his team's top choice out of the backfield. Judkins has now surpassed 90 total yards in all three games in which he played 50% of his team's snaps, which is a highly encouraging sign for managers who drafted him. With quarterback Dillon Gabriel earning a trial run as the starter, Cleveland is likely to continue riding two-tight end sets and its running game, making Judkins an excellent fantasy commodity going forward.

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Cleveland Browns tight end David Njoku scored and led his team in receiving on Sunday against the Minnesota Vikings, turning nine targets into six catches for 67 yards and a touchdown. Unfortunately for Cleveland, it wasn't quite enough, as the offense couldn't seal the game and the defense surrendered the lead in the final 30 seconds. The big tight end, however, had his best game of the season with rookie quarterback Dillon Gabriel, who found both Njoku and fellow tight end Harold Fannin Jr. for touchdowns. The Browns' typically volatile QB situation presents risk, but Sunday was an encouraging day for fantasy managers that showed Njoku still can be a productive fantasy player, even alongside Fannin getting targets and a rookie throwing the ball.

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Minnesota Vikings wide receiver Justin Jefferson again showed why he's one of the best in football Sunday against Cleveland, going for seven catches and 123 yards in Minnesota's 21-17 comeback win in London. The All-Pro drew a game-best 11 targets and pulled down an excellent 21-yard catch on one of the NFL's top corners, Cleveland's Denzel Ward, to aid the Vikings' game-winning, 80-yard touchdown drive in the fourth quarter. Fantasy managers have to be encouraged by Jefferson's past two weeks, in which he drew 11 targets and surpassed 100 yards in both games. The beat-up Vikings will take their bye in Week 6 before likely seeing the return of starting quarterback J.J. McCarthy (ankle) in Week 7.

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Cleveland Browns quarterback Dillon Gabriel finished his first NFL start with solid if unremarkable numbers, completing 19 of 33 passes for 190 yards, two touchdowns, and no turnovers in a 21-17 loss to the Minnesota Vikings. The rookie from Oregon had some encouraging moments, including a rocket second-half touchdown pass to tight end David Njoku, but the Browns coughed up the lead in the final 30 seconds and were not able to recover. Cleveland's offense ran more running plays until the final drive, rushing for 140 yards on 32 yards, but Gabriel crucially stayed away from any catastrophic mistakes against a Vikings defense that often frazzles young quarterbacks. As long as he's the starter, Gabriel should carry some Superflex appeal based on matchups.

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Houston Texans running back Dameon Pierce is active for Sunday's Week 5 contest against the Baltimore Ravens. He had previously been a healthy scratch and hasn't seen the field since the season opener. While this week's development is a step in the right direction for Pierce, his exact role remains unclear. Houston has a very crowded backfield with Nick Chubb and Woody Marks atop the depth chart, as well as British Brooks, Dare Ogunbowale, and Pierce in depth roles. The former Florida product should be avoided in all fantasy leagues as long as the rest of his fellow running backs stay healthy.

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ESPN's Adam Schefter reports that Arizona Cardinals running back Emari Demercado "will stay in the same role" on third downs. Meanwhile, Michael Carter will take over on first and second downs with Trey Benson (knee) out four to six weeks after having surgery on his meniscus. James Conner (ankle) has already been lost for the year, so the Cardinals' backfield depth is being tested early on. Arizona could plan more designed runs for slippery quarterback Kyler Murray, too. Demercado had two carries for eight yards and caught both of his targets for 13 yards and a touchdown in the Week 4 loss to the Seattle Seahawks. While the 26-year-old will be more involved with Benson out, it's Carter that should see more volume, and thus be a better flex play in fantasy lineups, starting this Sunday against the winless Tennessee Titans. Demercado is a better flex option in PPR formats.

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Miami Dolphins running back Jaylen Wright (coach's decision) is inactive for Sunday's Week 5 contest against the Carolina Panthers. Wright remains the odd man out of Miami's backfield rotation as he hasn't registered a rushing attempt so far this season. He remains off the fantasy radar pending an injury to one of Miami's other running backs. Going forward, De'Von Achane will remain Miami's No. 1 running back while Ollie Gordon II backs him up.

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San Francisco 49ers RB Christian McCaffrey was fined $23,186 by the National Football League for using his helmet on an attempted tackle by Jacksonville Jaguars LB Devin Lloyd during the fourth quarter of Week 4's game.

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New York Giants running back Tyrone Tracy Jr. (shoulder) has officially been ruled out for Sunday's Week 5 tilt on the road against the New Orleans Saints, according to Dan Salomone of Giants.com. New York will be without Tracy for a second straight game due to a dislocated right shoulder that he suffered in the Week 3 loss to the Kansas City Chiefs. The good news is that the 25-year-old was able to practice for the first time on Friday, so he could have a chance to return for a Week 6 divisional clash next Thursday night against the Philadelphia Eagles. In the meantime on Sunday in the Big Easy, rookie Cam Skattebo will be New York's lead back again, and he should be a strong RB2 option with RB1 upside against the winless Saints. Devin Singletary will also have an expanded role for the second straight week. Tracy could be the clear RB2 for the G-Men behind Skattebo when he returns from his shoulder injury.

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Dallas Cowboys running back Miles Sanders (ankle, knee) is officially inactive for the Week 5 game on the road against the New York Jets at MetLife Stadium on Sunday, according to Nick Harris of the Fort Worth Star-Telegram. Sanders came into this game listed as questionable despite not being able to practice all week. With the 28-year-old out of action for the first time this season, rookie Jaydon Blue will suit up for his NFL debut as the backup behind starter Javonte Williams. Although the fifth-round rookie might be eased into the offense in his first regular-season game, Blue is worth stashing in deeper leagues for his upside the rest of the season. It's unclear if Sanders will be able to return in Week 6 against the Carolina Panthers. In addition to Blue, Hunter Luepke could have a bigger role in Dallas' backfield on Sunday behind Williams.

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With Dallas Cowboys running back Miles Sanders (ankle, knee) ruled out in Week 5 against the New York Jets on Sunday, rookie fifth-rounder Jaydon Blue will be active for his NFL debut at MetLife Stadium, according to Nick Harris of the Fort Worth Star-Telegram. Blue impressed the coaching staff with his playmaking ability during training camp and the preseason, but he was a healthy scratch in each of the first four games of the year. The 21-year-old will get his opportunity in Week 5 with Sanders banged up, although Javonte Williams will most likely remain Dallas' bell-cow back, leaving little work for Blue and Hunter Luepke on Sunday. It's unclear if Sanders will miss time beyond Week 5, but right now, the rookie is merely a bench stash for those with Williams rostered or for fantasy managers hurting at the RB position.

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New Orleans Saints tight end Foster Moreau (knee) is officially active on Sunday and will make his 2025 season debut in Week 5 against the visiting New York Giants, according to Matthew Paras of The New Orleans Times-Picayune. Both Moreau and quarterback/tight end Taysom Hill (knee) are making their season debuts this weekend after they suffered torn ACLs last year. Juwan Johnson has been heavily involved through the first four weeks with Hill and Moreau sidelined, and he should continue to be a big part of their passing attack. The 28-year-old Moreau tore his ACL in Week 18 last year. He should be the TE3 in New Orleans now that he's healthy, which makes him one to avoid in all leagues. Last year, Moreau caught 32 passes for 413 yards and five touchdowns in 17 games.

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The Miami Dolphins have declared QB Quinn Ewers, CB Storm Duck, RB Jaylen Wright, WR Cedrick Wilson and DT Zeek Biggers inactive for Week 5.

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The New Orleans Saints have declared DT Khristian Boyd, RB Devin Neal, OG Cesar Ruiz, OT Xavier Truss, DE Chase Young and CB Isaac Yiadom inactive for Week 5.

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Baltimore Ravens safety Kyle Hamilton (groin) and left tackle Ronnie Stanley (ankle) are inactive for Sunday's Week 5 contest against the Houston Texans. Both players had been listed as questionable. Hamilton's absence was widely expected since he didn't practice this past week. Stanley, however, was a little more up in the air after he logged three limited sessions. In the end, though, neither starter will suit up. Baltimore is dealing with plenty of injuries on both sides of the ball, so this news is far from ideal. Reuben Lowery and Sanoussi Kane should earn more snaps at safety while Joseph Noteboom steps up to protect Cooper Rush's blindside.

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New Orleans Saints quarterback/tight end Taysom Hill (knee) is officially active for his 2025 season debut in Week 5 on Sunday against the visiting New York Giants, according to Matthew Paras of The New Orleans Times-Picayune. Hill was activated from the Physically Unable to Perform list on Saturday and will play for the first time this year after suffering a torn ACL in Week 13 of 2024. He will be the backup QB behind starter Spencer Rattler while also serving in his normal gadget role in head coach Kellen Moore's offense. The 35-year-old do-it-all offensive piece will give the Saints offense a boost as they search for their first win of the season, but it's difficult to project how involved he'll be in his first game of the year. Hill is worth a bench stash as a tight end in deeper leagues, but he'll most likely be a boom/bust fantasy asset all year.

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The Houston Texans have declared WR Braxton Berrios, OT Trent Brown, OT Jarrett Kingston, S Zion Childress, LB Christian Harris and QB Graham Mertz inactive for Week 5.

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The New York Giants have declared QB Jameis Winston, RB Tyrone Tracy Jr., S Demetrius Flannigan-Fowles, DT Elijah Garcia and OG Evan Neal inactive for Week 5.

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New York Jets running back Kene Nwangwu (hamstring) was downgraded to out ahead of Sunday's Week 5 contest against the Dallas Cowboys. This hardly comes as a surprise after Nwangwu missed all three practices earlier this week. The 27-year-old is headed for his fourth consecutive absence, leaving Isaiah Davis in line to handle kick return duties once again.

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