San Francisco 49ers tight end George Kittle (hamstring), who is still on Injured Reserve, returned to a limited practice on Wednesday, according to head coach Kyle Shanahan. The 49ers have designated Kittle to return from IR, which means they now have 21 days to officially activate him to return him to their 53-man active roster. It gives the 32-year-old Pro Bowl tight end a chance to return for a Week 7 date on Sunday Night Football against the Atlanta Falcons, but it doesn't mean it will actually happen. Fantasy managers are surely itching to get Kittle back into their starting lineups, but he's firmly up in the air to play this week. The 49ers would have to activate Kittle from IR by Saturday if they intend to play him on Sunday night. Kittle is a no-doubt TE1 in fantasy when he's active. If the Niners decide to wait another week to activate him, Jake Tonges would continue to have TE2 streaming appeal for one more week.

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San Francisco 49ers quarterback Brock Purdy (toe) put in a limited practice on Wednesday, according to head coach Kyle Shanahan. The 49ers are hoping that Purdy can put in more work at practice this week, which could potentially give him a chance to return to starting duties in Week 7 on Sunday Night Football against an improved Atlanta Falcons defense. Purdy suffered a turf-toe injury in Week 1 and missed Weeks 2 and 3. He then aggravated his toe injury in his return in Week 4 and hasn't played since. Backup Mac Jones (knee, oblique) has played well in Purdy's absence, but there's no question that Purdy is San Fran's starter when healthy. Purdy will likely need to put in a full practice to avoid a questionable tag this week. If he's able to return, he could be getting star tight end George Kittle (hamstring) back from Injured Reserve, too. In his two starts, Purdy has averaged 24.2 fantasy points, which ranks fourth among all QBs in 2025.

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Pittsburgh Steelers quarterback Aaron Rodgers has played turnover-free football over his past two games and is primed for another solid showing against the Cincinnati Bengals on Thursday night. Cincinnati's defense has struggled this season, allowing the second-most passing yards and 11th-most fantasy points per game to opposing quarterbacks. Although he'll once again be without wide receiver Calvin Austin III (shoulder), Rodgers has developed strong chemistry with DK Metcalf while also finding success targeting his tight ends and running backs. The 41-year-old is likely available in most single-QB formats but can be streamed as a solid option in this divisional clash.

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Arizona Cardinals wide receiver Marvin Harrison Jr. (concussion) remains in the league's concussion protocol, but he was listed as limited for the team's walk-through practice on Wednesday, according to Zach Gershman of AZCardinals.com. Harrison's status for the Week 7 contest against the visiting Green Bay Packers on Sunday is up in the air after he suffered a concussion in the Week 6 loss to the Indianapolis Colts. It's a good sign that he was on the practice field on Wednesday, but the second-year pass-catcher will need to gain clearance from the league's concussion protocol later this week to play on Sunday. Arizona's WR corps is banged up right now, with Zay Jones (knee) missing practice, and Michael Wilson (foot) being limited. If Harrison gets the green light to play, he could be working with backup quarterback Jacoby Brissett for a second straight game, with Kyler Murray dealing with a mid-foot sprain.

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Dallas Cowboys wide receiver CeeDee Lamb (ankle) was officially limited in his return to the practice field on Wednesday, according to Mike Garafolo of NFL Network. Fellow wideout KaVontae Turpin (foot) also returned to a limited practice after missing the last two games. Lamb is practicing for the first time since suffering a high-ankle sprain in the Week 3 loss to the Chicago Bears. While the 26-year-old is making progress, he's not a lock to return this Sunday to face the division-rival Washington Commanders. With that said, the Cowboys are saying there is a "good chance" that the star pass-catcher will be back this weekend. Fantasy managers would love to see Lamb put in a full practice on Thursday or Friday. As long as Lamb's workload isn't limited if he returns in Week 7, he should be considered a must-start in fantasy lineups against a leaky Commanders secondary.

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Las Vegas Raiders wide receiver Jakobi Meyers (knee, toe) is dealing with knee and toe injuries and was not present at practice on Wednesday, according to ESPN's Ryan McFadden. It's unclear exactly if Meyers' two injuries will put him in danger of suiting up for a Week 7 divisional battle against the Kansas City Chiefs this Sunday. The 28-year-old was able to play 90% of the offensive snaps in last Sunday's victory over the Tennessee Titans, though, catching all four of his targets for 39 yards. We'd think Meyers would be fine for this weekend as long as he returns to practice on Thursday or Friday. He has not shown much chemistry with quarterback Geno Smith this year, and his production has been disappointing in the two games that star tight end Brock Bowers (knee) has missed. If Meyers suits up in a tough matchup against KC, he should be considered a low-ceiling WR3 in fantasy football.

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Washington Commanders wide receiver Deebo Samuel Sr. (heel) continues to deal with a nagging heel injury and was listed as a non-participant at the first practice of the week on Wednesday. Samuel missed a couple of practices last week as well and was listed as questionable, but he played through his heel injury in Monday night's loss to the Chicago Bears. The 29-year-old was noticeably quiet, though, catching four passes for only 15 yards while playing 70% of the offensive snaps. It remains to be seen if his troublesome heel will slow him down again in Week 7 against the division-rival Dallas Cowboys, but as long as he's active, Samuel should be in starting fantasy lineups in a strong matchup. However, Samuel's fantasy ceiling will be lowered if Terry McLaurin (quadriceps) returns this weekend from a three-game absence. Samuel's status for the rest of the week also bears watching closely.

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Las Vegas Raiders tight end Brock Bowers (knee) did not practice on Wednesday, according to Ryan McFadden of ESPN. Bowers has not played since Week 4 due to a PCL injury to his knee that he initially injured in the season opener. It was reported last weekend that the second-year TE was unlikely to play in Week 7 against the division-rival Kansas City Chiefs. With the Raiders' bye coming in Week 8, his next chance to suit up will be in Week 9 against the Jacksonville Jaguars on Nov. 2. The 22-year-old looked well on his way to another beastly season after posting 103 receiving yards in Week 1. Still, he was unable to top 50 yards in the next three games, and now he's on track to miss a third straight game. Fantasy managers can only stay patient and hope he returns in Week 9 at full strength. With Bowers likely out again this weekend, Michael Mayer will be a viable TE2 streamer after catching five passes for 50 yards and a touchdown in last week's win over the Tennessee Titans.

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New Orleans Saints running back Alvin Kamara (ankle) is basically on a maintenance schedule for his ankle, which is why he did not take part in practice on Wednesday, according to Katherine Terrell of ESPN. Head coach Kellen Moore said Kamara missing practice or being limited on Wednesdays won't necessarily be the case for the rest of the year, but it's the plan for right now. The 30-year-old veteran was limited in practice all of last week but still played in the Week 6 loss to the New England Patriots. Kamara played 62% of the offensive snaps and had 15 touches for 76 scrimmage yards. As long as he's able to get back to a limited practice on Thursday or Friday, Kamara should be fine to suit up this Sunday on the road in Chicago against the Bears. Although he's still the lead back in the Big Easy, Kamara has descended to RB2/3 status in fantasy. It doesn't help that Taysom Hill is now back to potentially steal goal-line touches as a RB.

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Arizona Cardinals quarterback Kyler Murray (foot), who missed last week's loss to the Indianapolis Colts on Sunday, returned to practice on Wednesday and was limited, according to Tom Pelissero of NFL Network. Although it's good news that the 28-year-old signal-caller is on the practice field, he's dealing with a mid-foot sprain and is not a lock to return in Week 7 against the visiting Green Bay Packers. Veteran Jacoby Brissett's strong performance in Murray's absence last Sunday could also lead the Cardinals to play it safe with Murray this week and hold him out again as a precaution. It sounds like Arizona has no plans to rush Murray back into action, so fantasy managers need to have a backup plan in place in case he misses a second straight start. Through five games played, Murray has been a disappointment as a QB1 option in fantasy, ranking 24th among all QBs with an average of 19.1 fantasy points per game.

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Washington Commanders wide receiver Terry McLaurin (quadriceps) was limited in his return to practice on Wednesday, per Adam Schefter of ESPN. It's good news to see McLaurin back on the practice field, even if the Commanders only held a walk-through session. The 30-year-old veteran has missed the team's last three games due to a pretty serious quad injury, and he's still up in the air as to whether he'll be able to play this weekend versus the division-rival Dallas Cowboys on Sunday. McLaurin could have his snaps limited if he returns in Week 7, too, so he's still a pretty dicey fantasy option that managers shouldn't be counting on. Washington put Noah Brown (groin, knee) on Injured Reserve, and Deebo Samuel Sr. (heel) was less than 100% in Monday's loss to the Chicago Bears, so the team's WR corps is pretty banged up. If McLaurin misses another game, both Luke McCaffrey and Jaylin Lane will see more opportunities in the passing game.

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San Francisco 49ers wide receiver Ricky Pearsall (knee) was not present at practice on Wednesday, according to David Lombardi of The Athletic. Pearsall has made progress in recovery from a knee sprain that he suffered in Week 4, but he's not quite ready to return to the practice field. The 25-year-old former first-rounder is making progress, but he might be forced to miss a third straight game this weekend when the Niners take on the Atlanta Falcons on Sunday night. Pearsall has two more days to get back onto the practice field, but it seems like he's trending toward another absence. The good news for the 49ers is that quarterback Brock Purdy (toe) and tight end George Kittle (hamstring) practiced on Wednesday, so they could both make their returns this weekend. Pearsall should be stashed in all fantasy leagues, but he should be left on your bench again this week.

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New York Giants wide receiver Darius Slayton (hamstring) missed the first practice of the week on Wednesday, according to Dan Salomone of Giants.com. Slayton suffered a hamstring injury in the Week 5 loss to the New Orleans Saints and didn't practice on a short week before missing last Thursday night's upset win over the Philadelphia Eagles. Another DNP to begin Week 7 preparation is a bad sign, but Slayton still has two more days to get back onto the practice field. If the 28-year-old cannot do so, he'll miss a second straight game this Sunday versus the Denver Broncos on the road. Slayton figures to be one of New York's top pass-catchers the rest of the year now that Malik Nabers (knee) is done for the season, but he needs to get healthy first. If Slayton gets cleared to play on Sunday, he'll be a WR4/flex, at best, against a stingy Denver defense.

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Indianapolis Colts wide receiver Josh Downs (concussion) is in the league's concussion protocol this week, according to Stephen Holder of ESPN. Fellow wideout Ashton Dulin (chest) also missed practice on Wednesday with a chest injury. Downs had a strong game in the Week 6 win over the Arizona Cardinals, catching six of his seven targets for 42 yards and a touchdown, but he could be forced to miss a Week 7 contest on the road against the Los Angeles Chargers unless he's cleared from the concussion protocol later this week. If Downs is unavailable this weekend, Adonai Mitchell could be active once again as WR depth after being a healthy scratch last Sunday. Alec Pierce would be elevated to the WR2 role behind Michael Pittman Jr. and would be in play as a WR4/flex in fantasy lineups. In the last two games, Downs has come on strong, catching 12 total passes (15 targets) for 96 yards and a score.

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Carolina Panthers head coach Dave Canales wouldn't say for sure if running back Rico Dowdle will start on Sunday at RB against the New York Jets, but would only say that Dowdle "has earned the right to help this team and we will find a way (for him) to do that." Chuba Hubbard (calf) has missed the last two games, and in that time, Dowdle has amassed more than 400 scrimmage yards and two touchdowns on 60 total touches. At the very least, the 27-year-old has earned a backfield split with Hubbard, who could return this weekend after practicing on Wednesday for the first time since Week 4. Before Hubbard's injury, he was solid in his own right as the Panthers' starting RB. It's a good problem to have for Carolina. If Hubbard is back in Week 7, the backfield touches figure to be split more evenly, making things more cloudy for fantasy managers.

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Las Vegas Raiders running back Ashton Jeanty recorded a season-high 23 rush attempts for 75 yards and a touchdown in their 20-10 win over the Titans in Week 6. Head coach Pete Carroll spoke on Wednesday regarding the workload for his star rookie running back and said that he hopes that is the norm for him moving forward. Jeanty has topped 20 carries twice this season, including a career-high performance in Week 4 against the Bears, when he rushed for 138 yards and scored three total touchdowns. He hasn't been very efficient running behind a poor run-blocking offensive line, but his touch volume ranks among the highest at the position. Jeanty will rank as a low-end RB1 in Week 7 against the Chiefs.

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Kansas City Chiefs wide receiver Rashee Rice's six-game suspension is over, and he will make his 2025 debut in the Week 7 divisional clash against the Las Vegas Raiders this Sunday. "He's going to play (Sunday against the Raiders). How many snaps he'll get, (I don't know). He's been working hard. He's in good shape," head coach Andy Reid said. Rice is practicing with the rest of the team for the first time this year on Wednesday. According to ESPN's Jeremy Fowler, the Chiefs "will be allocating a heavy workload for him as soon as possible," so fantasy managers will want to get Rice back into their starting lineups immediately in a good matchup. In addition to his six-game suspension, the 25-year-old is back from an LCL tear in his knee that he suffered in the offseason. When fully healthy, Rice is expected to be quarterback Patrick Mahomes' favorite target.

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Carolina Panthers tight end Ja'Tavion Sanders (ankle) was listed as limited in the team's Wednesday practice report. Sanders has missed three straight games as he continues to nurse an ankle issue, but he is trending in the right direction with a practice to begin the week. Sanders was productive in the three games he played, catching 11 of 14 targets for 92 yards. If he's unable to go again in Week 7, the tight end snaps will be mixed again between Tommy Tremble, Mitchell Evans, and James Mitchell.

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Carolina Panthers wide receiver Jalen Coker (quadriceps) was a full participant in practice on Wednesday. Coker was apparently "really close" to returning to the field in Week 6 against the Cowboys, according to head coach Dave Canales, but the team opted to give him another week. His practice window was opened, and he practiced in full every day in practice last week, which should give him a good chance at making his season debut in Week 7 against the Jets. The 23-year-old could slide in immediately as the No. 2 wide receiver behind star rookie Tetairoa McMillan, as no other Carolina pass catcher has emerged. Coker is a worthwhile pickup off the waiver wire in 12-team leagues where available.

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Los Angeles Chargers wide receiver Quentin Johnston (hamstring) will participate in practice on Wednesday, according to Kris Rihm of ESPN. Johnston missed his first game of the season against Miami in Week 6, but looks to be on the right track to return in Week 7, although he was limited in practice throughout last week and ultimately didn't suit up. Johnston has had a fantastic start to his third season through five games, racking up 26 catches on 40 targets for 377yards and four touchdowns. The 24-year-old leads the team in receiving yards and touchdowns, even with missing one game. His status for Week 7 against Indianapolis should become clearer as the week goes on.

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