Tampa Bay Buccaneers running back Bucky Irving (foot, shoulder) was not seen at the portion of practice open to the media on Thursday, according to Rick Stroud of the Tampa Bay Times. Irving missed the Week 5 win over the Seattle Seahawks due to a sprained left foot and a subluxation of his shoulder, and he's tracking towards a second straight missed game in Week 6 against the San Francisco 49ers since he has yet to take the practice field this week. With the 23-year-old sidelined last Sunday, Rachaad White took advantage of lead-back duties to score two touchdowns. He had 14 carries for 41 yards and caught four passes for an additional 30 yards. With Irving looking unlikely to play again this weekend, White will once again be in play as an RB2 in fantasy lineups, and he could see even more targets in the passing game if receiver Chris Godwin (leg) is unable to play.

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Tampa Bay Buccaneers wide receiver Chris Godwin (leg) was not seen at Thursday's portion of practice open to the media, according to River Wells of Bucs Gameday. Godwin also sat out the first practice of the week on Wednesday with a fibula injury, putting his status for Sunday's contest against the San Francisco 49ers in Week 6 in question. Mike Evans (hamstring) remains sidelined and is expected to miss another game this weekend, so if Godwin is out as well, Sterling Shepard would be the clear WR2 for quarterback Baker Mayfield behind impressive rookie first-rounder Emeka Egbuka. In addition to Shepard seeing an increased role, Tez Johnson and Ryan Miller would be in line for more offensive snaps if Godwin cannot play in Week 6. Godwin didn't make his 2025 debut until Week 4 after recovering from a dislocated ankle in Week 7 of last year. In his first two games this season, he has caught six of 14 targets for 52 scoreless yards.

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Atlanta Falcons wide receiver Darnell Mooney (hamstring) will not practice on Thursday, but he's being considered day-to-day coming out of the bye week and heading into a Monday night game in Week 7 against the Buffalo Bills, according to Terrin Waack of AtlantaFalcons.com. "Right now, Mooney is still day-to-day. We'll see what that is. He'll be out today. We'll get a good feel for what it looks like moving forward," head coach Raheem Morris said. It's not a great sign that Mooney isn't taking part in the first practice of the week, especially coming out of the bye week. There's still time for the 27-year-old to return to the field in the next couple of days, but right now, there is some doubt about whether he'll be able to suit up versus Buffalo. Mooney has been a disappointment for fantasy managers through three games, catching just seven of his 16 targets for 79 yards.

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San Francisco 49ers general manager John Lynch reports that quarterback Mac Jones (knee, oblique) should be ok for Sunday's matchup with the hosting Tampa Bay Buccaneers. The former Alabama Crimson Tide aggravated a PCL injury in Week 5's overtime win over the Los Angeles Rams, causing him to be a limited participant in Wednesday's practice session. Per Lynch's comments, it doesn't appear to be a concern. He'd also note that fellow signal-caller Brock Purdy (toe) is "working to get back but wants to get back at full strength," hinting that he may be a few weeks away. If, for some reason, neither athlete can suit up in Week 6, Adrian Martinez will get the nod at Raymond James Stadium.

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The Houston Texans have yet to make an indication that wide receiver Tank Dell (knee) will return any time soon. Dell sustained a gruesome knee injury late last season, and there has been no update on his status. The sentiment surrounding the 25-year-old was that he'd likely miss the entirety of the 2025 season. While no news is good news -- insinuating that he hasn't had a setback in his recovery -- it's still a long shot that he'd be able to make his way back to the field by the end of the campaign. As of now, teammates Christian Kirk and Xavier Hutchinson will continue to operate behind the team's WR1, Nico Collins. However, rookies Jaylin Noel and Jayden Higgins could begin to push the veterans for playing time.

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Despite limited playing time early on in his rookie season, Los Angeles Rams tight end Terrance Ferguson has earned a more significant role in the team's offense. The University of Oregon product has had a slow start to the season after battling a groin injury in training camp. While he's only appeared on the field for eight total snaps across two contests, head coach Sean McVay has taken note of his development and intends to get him more involved in the offense. "We have to be able to figure out a way to be able to get him going," said McVay. "He's going to be a really good player for us, I believe. I thought he did an excellent job with the opportunity that he had [last week]." Ferguson is firmly fourth in LA's TE pecking order, but it wouldn't be surprising to see him pick up more playing time moving forward. It remains to be seen if he'll become a viable play in redraft leagues this season, but he's an excellent stash in dynasty formats.

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Kansas City Chiefs running back Kareem Hunt remains a low-end RB3/flex option ahead of his Week 6 matchup with the Detroit Lions. For the most part, Hunt has played behind backfield mate Isiah Pacheco in terms of snaps. However, the veteran boasts more carries (43) and yards (164) than Pacheco, and has the team's goal-line role on lockdown. With that said, the 30-year-old's workload has been limited, as he has yet to see more than 14 touches in a single contest. Furthermore, Kansas City has been one of the more pass-happy teams in the league, and quarterback Patrick Mahomes leads the team in rushing (190). Hunt is a fine start considering his touchdown upside, but he has yet to eclipse 5.7 fantasy points in the appearances he didn't hit pay dirt.

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According to Miami Dolphins offensive coordinator Frank Smith, quarterback Tua Tagovailoa (hip, thumb) is expected to be "without hindered performance" in Week 6 when his team squares off with the visiting Los Angeles Chargers. The 27-year-old was a limited participant at Wednesday's practice after picking up thumb and hip injuries in their loss to the Panthers in Week 5. Tagovailoa didn't appear to be hampered by the injuries last weekend, and it's good news that the team expects him to be ready on Sunday. Fantasy managers will want to continue keeping an eye on his status over the next few days, but it doesn't seem that he'll be in danger of being inactive.

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Denver Broncos tight end Evan Engram found the end zone for the first time this season in Week 5, but his overall production remains underwhelming. Through five games, Engram has caught 12 of 19 targets for 95 yards and a touchdown while struggling to carve out a consistent role in Denver's offense. Engram continues to split reps with Adam Trautman and Nate Adkins, limiting his snap share to just 41%, which ranks 56th among all tight ends. He also ranks 30th in route participation (53.9%) and 27th in fantasy points per game, highlighting his diminished opportunity in Sean Payton's offense. The Broncos face the New York Jets in Week 6, who have allowed the sixth most fantasy points to tight ends this season, but until Engram's usage increases, he's best left on the waiver wire in most formats.

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Seattle Seahawks quarterback Sam Darnold has been one of the NFL's most efficient passers through the first five weeks of the season. The veteran has completed 73% of his passes (third-best in the NFL) while ranking seventh in both passing yards and touchdowns. After a breakout 2024 campaign in Minnesota, where he threw for 4,319 yards and 35 touchdowns, some questioned whether Darnold could replicate that success in Seattle. So far, he's answered emphatically. With Jaxon Smith-Njigba emerging as a true No. 1 receiver, Darnold is producing like a top-10 fantasy quarterback. The Seahawks face the Jacksonville Jaguars in Week 6, who lead the NFL in interceptions, making Darnold a slightly risky start. Still, he remains a strong high-end QB2 with weekly upside in fantasy leagues moving forward.

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Pittsburgh Steelers running back Kenneth Gainwell exploded in Week 4's game in Ireland, but fantasy managers should temper expectations moving forward. With Jaylen Warren sidelined against the Minnesota Vikings, Gainwell took full advantage of the opportunity, racking up 134 total yards and two touchdowns on 25 carries. With Warren practicing ahead of Week 6, the former Eagles back will return to his RB2 role in the offense. A tough Week 6 matchup against the Cleveland Browns looms large, as Cleveland has allowed the fewest rushing yards in the NFL through five weeks. Even if he continues to earn touches behind Warren, Gainwell remains a risky fantasy start this week.

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New England Patriots running back Rhamondre Stevenson is poised for an increased workload moving forward. Through five games, Stevenson has totaled 293 scrimmage yards and two touchdowns on 51 carries, leading all New England running backs in usage. With Antonio Gibson (knee) suffering a season-ending injury, both Stevenson and rookie TreVeyon Henderson are expected to see expanded roles. While Stevenson has battled ball-security issues over the past two seasons, he remains the favorite for early-down and goal-line work. Henderson, meanwhile, should see his role grow in the passing game, giving him PPR appeal in deeper formats. Both backs carry fantasy value moving forward, and each should be rostered in all leagues as the Patriots' backfield reshapes for the rest of the season.

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Washington Commanders wide receiver Terry McLaurin (quad/hip) appears unlikely to suit up in Week 6 against the Chicago Bears. The veteran wideout has missed the past two games with a lingering quad injury and did not practice on Wednesday, putting his status in serious doubt. McLaurin signed a new contract before the season but has struggled to find his rhythm, a trend that has been common among receivers coming off holdouts or limited offseason participation. Through three games, he's caught 10 of 17 targets for 149 yards and has yet to score a touchdown. In McLaurin's absence, free-agent addition Deebo Samuel Sr. has emerged as the Commanders' top receiving option. Fantasy managers should monitor practice reports on Thursday, Friday, and Saturday to determine if McLaurin has any chance to return this week.

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Atlanta Falcons wide receiver Darnell Mooney (hamstring) has been among the disappointing fantasy receivers this year, but could return to his regularly scheduled role in Week 6. According to Marc Raimondi of ESPN, Falcons coach Raheem Morris said he would have more information on the receiver following Thursday's practice, but the team initially believed the injury would not force Mooney to miss any games. Mooney has not yet had a big fantasy week in 2025, but did draw 11 targets in his last full game. He's still sharing targets with Drake London, but he finished last year as the No. 31 overall fantasy receiver alongside London also. Given good health, Mooney could be due to return to a workload more similar to last season in the coming weeks.

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New Orleans Saints running back Kendre Miller should be rostered in all fantasy leagues heading into Week 6. The rookie has seen his workload steadily increase, logging back-to-back games with double-digit carries and totaling 119 yards and a touchdown over that span. Starting running back Alvin Kamara suffered an ankle injury during Wednesday's practice, putting his status for the Week 6 matchup against the New England Patriots in question. Even if Kamara suits up, his workload could be limited, giving Miller a strong chance to see meaningful touches once again. Beyond the short-term upside, Miller offers long-term appeal as well. Trade rumors have begun to swirl around Kamara, with reports suggesting the Saints could move him to a contending team before the deadline. If that happens, Miller would immediately step into a featured role. With both injury uncertainty and potential trade movement ahead, Miller should be added in all formats before his price skyrockets.

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According to a new story by Jordan Raanan of ESPN, the New York Giants view running back Cam Skattebo as both their top option of the present and the future. The rookie from Arizona State has received the lion's share of work with Tyrone Tracy Jr. (shoulder) out for the past couple weeks, but the team apparently views Skattebo as their preferred option for the near term. Fantasy managers have seen nice return on investment in Skattebo, especially in PPR formats, in which his 14 catches the past three games has paired nicely with 198 rushing yards and a touchdown. The split between the two backs will be worth watching, but it seems like Skattebo will carry the upper hand.

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Carolina Panthers offensive coordinator Brad Idzik alluded to more of a platoon at running back after Rico Dowdle's 200-yard explosion in Week 5 against Miami, according to David Newton of ESPN. The OC said Dowdle having so much success is a "good problem to have" when Hubbard (calf) returns from injury. Hubbard, who didn't practice Wednesday, had been the clear top option for the Panthers, playing in 50-plus percent of the team's offensive snaps every week he appeared. But after Dowdle went for 206 rushing yards, a touchdown, and three catches for another 28 yards, the team obviously liked what it saw. Managers should prepare for the possibility that both backs will play going forward for Carolina.

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The Jacksonville Jaguars will spend the next month without tight end Brenton Strange (quadriceps), opening the door for fellow tight end Hunter Long to see a major increase increase in snaps heading into Week 6. The Jags placed Strange on injured reserve on Tuesday, assuring he's out through Week 9, and Long seems likely to take on significantly more snaps. When Strange departed Monday's win against Kansas City, Long played 60% of the team's offensive snaps, though it led to only one target. Managers should dial back expectations, as the fifth-year man has never been much of a fantasy asset, though he'll have an opportunity like never before as the Jags rely on him and Johnny Mundt to take on bigger roles for the four weeks.

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Kansas City Chiefs wide receiver Tyquan Thornton could be in line for at least another week of additional opportunity in Week 6 after going for a season-high in yards in Monday night's loss to Jacksonville. The 25-year-old played 45% of the Chiefs' snaps and turned five targets into three catches for 90 yards, which could lead to some additional work as a downfield threat as K.C. aims to survive one more week without receiver Rashee Rice (suspension). The team still considers Rice to be its top target, but Thornton is part of the piecemeal effort to replace him, giving him some waiver appeal in an enticing matchup against Detroit in Week 6.

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The San Fransisco 49ers will spend at least one more week without star tight end George Kittle (hamstring), which opens the door for backup Jake Tonges to continue being a streaming option with his team set for a plus matchup against the Tampa Bay Bucs. The fourth-year man from Cal hasn't been an exact 1:1 replacement for Kittle's do-it-all skill set, but he's done well as a pass catcher, ranking in the top 10 among fantasy tight ends thanks to 19 receptions and three touchdowns in five weeks. Though Tonges' workload is going to decrease as soon as Kittle comes back, Tonges tied for the team lead in targets last week. He'll carry lineup appeal into Week 6, especially in formats that play more than one tight end.

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