Indianapolis Colts wide receiver Michael Pittman Jr. continued his hot start to the season in a 40-6 win over the Las Vegas Raiders in Week 5. Pittman caught five of his six targets for 39 yards and a touchdown in the blowout win, giving him scores in four of his five games this year. The veteran receiver has been posting modest yardage totals as he's averaging 54.6 yards per game thus far, but he's emerged as Daniel Jones' favorite target so far. Pittman will look to stay hot in a Week 6 home matchup against the Arizona Cardinals. The Cardinals are allowing just the 20th-most fantasy points per game to opposing wideouts this season, but Pittman can be utilized as a WR3 heading into Week 6.

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Despite finishing the game with just three catches for 20 yards, Pittsburgh Steelers tight end Darnell Washington was heavily involved in the Week 4 win over the Minnesota Vikings. Washington logged more snaps than any other Steelers tight end and was highly effective as a run-blocker, paving the way for running back Kenneth Gainwell's 99-yard rushing performance. According to head coach Mike Tomlin, Washington's increased utilization was by design. "You can't play 4-3 teams with 250-pound tight ends", Tomlin stated in a press conference on Tuesday. He also hinted that Washington could again see significant playing time in this week's divisional meeting with the Cleveland Browns, who boast a strong defensive front. The third-year pro isn't a fantasy option just yet, but if he continues to play ahead of Pat Freiermuth and Jonnu Smith again on Sunday, it will be worth monitoring whether that usage starts to show up in the box score.

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Indianapolis Colts wide receiver Josh Downs turned in his best game of the season in a Week 5 win over the Las Vegas Raiders. Downs caught six of his eight targets for a season-high 54 yards in a 40-6 blowout win on Sunday. The veteran wideout has been quiet to start the season, but he will hope his performance is a springboard to a larger role going forward. Downs will now prepare to host the Arizona Cardinals in Week 6. The Cardinals are allowing just the 20th-most fantasy points per game this year, but Downs should stay involved with Alec Pierce (concussion) expected to miss a third-straight game. Downs sets up as a WR5/flex option heading into Week 6.

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Indianapolis Colts tight end Tyler Warren has been one of the top rookies in the league this season. He stayed hot in a 40-6 win over the Las Vegas Raiders in Week 5, catching all four of his targets for 44 yards and a touchdown in the blowout win. Warren has now scored touchdowns in two straight games as he continues to operate as one of the top options in the Indy passing attack. The rookie will now turn his attention to a Week 6 home matchup against the Arizona Cardinals. The Cardinals have been a decent matchup for tight ends this season, allowing the 13th-most fantasy points per game to the position through five games. Warren sets up as a no-brainer TE1 in all fantasy leagues in Week 6.

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Cleveland Browns wide receiver Jerry Jeudy continued his slow start to the season in a Week 5 loss to the Minnesota Vikings in London. Jeudy finished with just two catches for 15 yards on five targets in the close loss to Minnesota. With Dillon Gabriel making his NFL debut, Jeudy finished third on the team in targets but was unable to do much with the looks, continuing what has been a disappointing campaign for Cleveland's No. 1 wideout. Jeudy now has just 15 catches for 197 scoreless yards through five games. He will hope to get things going in a Week 6 road matchup against a Pittsburgh Steelers defense that is allowing the seventh-most fantasy points per game to opposing receivers. That being said, Jeudy's production has been too poor to trust him in fantasy, even in a plus matchup.

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Indianapolis Colts quarterback Daniel Jones continued his hot start to the season in a 40-6 win over the Las Vegas Raiders in Week 5. Jones completed 20 of his 29 passes for 212 yards and two touchdowns in the blowout victory. The veteran quarterback's performance has been one of the best stories of the season as he now has thrown for 1,290 yards, six touchdowns, and two interceptions while adding three more rushing touchdowns. Jones will now prepare to host an Arizona Cardinals defense that has been tough on opposing passers this year. That being said, Jones has been consistent enough to trust as a low-end QB1 heading into Week 6.

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Cleveland Browns tight end Harold Fannin Jr. continued his hot start to the season in a Week 5 loss to the Minnesota Vikings in London. Fannin caught all four of his targets for 13 yards and a touchdown. The rookie tight end gave fellow rookie Dillon Gabriel his first NFL passing touchdown with a one-yard grab in the first quarter. Fannin has now caught 21 passes for 173 yards and one touchdown through five games as he has established himself as a top target in Cleveland. He will now head on the road to take on the Pittsburgh Steelers in Week 6. The Steelers have been quite generous to tight ends this season, allowing the fourth-most fantasy points per game to the position through four games. Fannin is looking like a low-end TE1 heading into Week 6.

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Cleveland Browns wide receiver Isaiah Bond caught just two of his seven targets for 29 yards in a Week 5 loss to the Minnesota Vikings in London. Bond finished second on the team in targets in the close loss but was unable to get on the same page as rookie Dillon Gabriel, who was making his NFL debut. That being said, Bond's involvement in the passing game has been encouraging of late as he's drawn 13 targets over his past two contests. He will head on the road to face off against the Pittsburgh Steelers in a divisional clash in Week 6. The Steelers have struggled against opposing receivers in four games this year, allowing the seventh-most fantasy points per game. Bond isn't a must-play, but he will be on the fantasy radar as a boom/bust flex option in a week with both the Vikings and the Houston Texans on bye.

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New Orleans Saints quarterback Spencer Rattler finally notched his first career win as a starter in Week 5 against the Giants, completing 21-of-31 passes for 225 yards and a touchdown. After averaging just 5.2 yards per attempt through the first four weeks, he finally connected deep with Rashid Shaheed for an 87-yard touchdown in the second quarter. It wasn't a complete shift in play style, but it was a positive sign for the young quarterback. Despite the Saints sitting at 1-4, Rattler looks locked in as the team's starter moving forward. He enters Week 6 as a QB2 with upside against a Patriots defense allowing 242.2 passing yards per game.

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New Orleans Saints running back Alvin Kamara recorded a season-low eight carries for 27 yards and added four receptions for 28 yards in the Week 5 win over the Giants. He has now gone five straight games without a touchdown as defenses continue to focus on stopping him. The run game could start to open up, however, as Rashid Shaheed's 87-yard touchdown reception may force defenses to respect the big-play threat. Another concern is that Kamara's snap count fell to a season-low 37, accounting for just 56% of the team's offensive snaps. With Kendre Miller emerging and trade rumors swirling around Saints veterans, fantasy managers should monitor Kamara closely. He ranks as an RB2 against the Patriots.

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New Orleans Saints tight end Juwan Johnson came back down to earth in Week 5, hauling in just two catches for 17 yards on four targets. After a hot start with 19 receptions for 176 yards and a touchdown over the first three weeks, he's averaged just 2.5 catches for 22.5 yards with no scores over his last two contests. Still, Johnson played 85% of snaps in Week 5, a surprising season low, but the returns of Taysom Hill and Foster Moreau will continue to cut into his opportunities. He remains the most talented pass catcher among Saints tight ends, but now ranks as a low-floor TE2 against the Patriots.

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The Philadelphia Eagles held a walkthrough practice on Tuesday, so their injury report was an estimation, according to Martin Frank of the Delaware News Journal. With that said, tight end Grant Calcaterra (oblique) was listed as a non-participant for the second straight day this week. It's looking unlikely that Calcaterra will be able to suit up on a short week on Thursday night against the division-rival New York Giants after he injured his oblique in the Week 5 loss to the Denver Broncos on Sunday. If Calcaterra is ruled out for Week 6 on Thursday, Kylen Granson will be bumped up to the TE2 role behind starter Dallas Goedert. Calcaterra was unable to take advantage of Goedert missing a game earlier this year, and he has only four catches on six targets for 40 yards in five games played in 2025. If Calcaterra is inactive on Thursday, his next chance to play would be in Week 7 against the Minnesota Vikings.

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After a 2024 campaign in which he set career highs as a receiver, Pittsburgh Steelers tight end Jonnu Smith has been surprisingly quiet to start 2025. Smith's limited participation in practice leading up to the Week 4 win over the Minnesota Vikings could explain his minimal involvement in that game, but his lack of utilization through the first three weeks was equally puzzling. Ideally, Pittsburgh used its Week 5 bye to find ways to get Smith going. This week, the 30-year-old will take on the division-rival Cleveland Browns, who have been tough on tight ends this year. His usage, alongside that of Pat Freiermuth and Darnell Washington, will be worth monitoring, but Smith remains off the fantasy radar in most formats.

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Philadelphia Eagles running back Saquon Barkley (knee) was upgraded to a limited participant on Tuesday's estimated practice report, according to Tom Pelissero of NFL Network. Barkley came out of Sunday's loss to the Denver Broncos with some general knee soreness and was listed as a non-participant on Monday's estimated practice report, leaving some doubt about his Week 6 status for Thursday night's divisional clash against the New York Giants. The 28-year-old is expected to suit up on a short week against his former team, and fantasy managers are hoping that he'll have a much bigger workload in a strong matchup. In the 21-17 loss to Denver in Week 5, Barkley saw a season-low usage with just nine touches for 88 yards. He salvaged his fantasy day by finding the end zone on a long reception. Barkley's knee shouldn't be an issue for Thursday's revenge game.

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Minnesota Vikings quarterback J.J. McCarthy (ankle) will get "extensive work" on the field during the team's bye this week, according to head coach Kevin O'Connell. McCarthy is officially returning to practice this week after missing three games due to a high right-ankle sprain that he suffered in the Week 2 loss to the Atlanta Falcons. Veteran Carson Wentz one two of his three starts with McCarthy sidelined, although he did suffer a left-shoulder injury in the Week 5 win over the Cleveland Browns in London that the team will monitor this week. McCarthy led a comeback in Week 1 over the Chicago Bears but looked like a rookie in Week 2 while playing through his ankle injury. O'Connell didn't exactly commit to McCarthy starting in Week 7 against the Philadelphia Eagles coming off the bye, so if Wentz's shoulder is alright, the veteran could make a fourth straight start.

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Pittsburgh Steelers wide receiver DK Metcalf delivered his best showing of the season in Week 4 with five receptions for 126 yards and a touchdown against the Minnesota Vikings. Although nearly all of his production came in the first half, it was encouraging to see the seventh-year pro featured early and often after a slow start to the campaign. Coming out of a Week 5 bye, Metcalf will get his first taste of an AFC North rivalry with the Cleveland Browns on tap for Week 6. While Cleveland has been strong defensively this season, it has still allowed five wideouts to finish as top-24 fantasy options in as many games. Fantasy managers may have safer choices this week, but Metcalf remains firmly in the WR2 mix.

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Through the first four weeks of the season, Pittsburgh Steelers quarterback Aaron Rodgers was the QB16 in fantasy with eight passing touchdowns and three interceptions while leading his new team to a 3-1 record. Although his most prolific outing came in the season opener, Rodgers finished as a top-24 fantasy option in each of his games. He'll now return from a Week 5 bye to face the division-rival Cleveland Browns in Week 6. Despite their 1-4 record, Cleveland has been stout defensively, limiting opposing quarterbacks to 15 fantasy points per contest. Rodgers can be added and started in favorable matchups, but he's not an ideal streaming candidate this week. The 41-year-old checks in as QB27 in RotoBaller's Week 6 rankings.

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The Los Angeles Chargers acquired edge rusher Odafe Oweh from the Baltimore Ravens on Tuesday, sources told Mike Garafolo of NFL Network. ESPN's Adam Schefter reports that the Chargers safety Alohi Gilman and a fifth-round pick in the 2026 draft to Baltimore, and also received a 2027 seventh-round draft pick. The Chargers will hope that Oweh can pick up some of the pass-rushing slack in Los Angeles with Khalil Mack (elbow) currently on Injured Reserve. The 26-year-old former first-rounder had a career-best 10 sacks and 39 tackles (25 solo) with the Ravens in his fourth NFL season in 2024. However, despite getting consistent pressure on opposing quarterbacks through five games this year, Oweh has yet to record a sack. Gilman will give the Ravens a much-needed healthy body for their banged-up secondary as they head into a Week 6 game against the Los Angeles Rams.

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The Tennessee Titans waived wide receiver Treylon Burks (collarbone) on Tuesday, according to Jim Wyatt of TennesseeTitans.com. Burks, a former first-rounder, suffered a fractured collarbone during practice in training camp and was waived with an injury designation back in July before reverting to Injured Reserve for the start of the regular season. He just was not able to stay on the football field in his time with the Titans, playing in just 27 games over the last three years. The 25-year-old pass-catcher had 53 catches for 699 yards and only one touchdown since debuting in 2022. Burks will be free to sign with any team if he clears waivers. He should get a look elsewhere, but it's unclear how soon he'll be ready to come off Injured Reserve. Burks remains a non-factor in fantasy, although maybe a change of scenery will treat him well.

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Arizona Cardinals running back Michael Carter is listed as the RB1 on the team's depth chart going into a Week 6 clash against the Indianapolis Colts on the road on Sunday. Emari Demercado is listed as the No. 2, with Bam Knight following him. James Conner (ankle) is out for the rest of the season, while Trey Benson (knee) is out four to six weeks due to a knee injury. In Arizona's new-look backfield in the Week 5 loss to the Tennessee Titans, Carter operated as the clear lead back, carrying the ball 18 times for 51 yards and a touchdown and catching all five of his targets for another 22 yards. Demercado and Knight combined for only nine touches, with Demercado botching what would have been a 70-plus-yard touchdown. Even though Carter wasn't very efficient with his 23 touches, it's clear the Cardinals are going to lean heavily on him with Benson out. Carter should be scooped up off waivers this week if he's still available in your league.

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