ESPN's Adam Schefter reports that Arizona Cardinals running back Emari Demercado "will stay in the same role" on third downs. Meanwhile, Michael Carter will take over on first and second downs with Trey Benson (knee) out four to six weeks after having surgery on his meniscus. James Conner (ankle) has already been lost for the year, so the Cardinals' backfield depth is being tested early on. Arizona could plan more designed runs for slippery quarterback Kyler Murray, too. Demercado had two carries for eight yards and caught both of his targets for 13 yards and a touchdown in the Week 4 loss to the Seattle Seahawks. While the 26-year-old will be more involved with Benson out, it's Carter that should see more volume, and thus be a better flex play in fantasy lineups, starting this Sunday against the winless Tennessee Titans. Demercado is a better flex option in PPR formats.

From RotoBaller

Miami Dolphins running back Jaylen Wright (coach's decision) is inactive for Sunday's Week 5 contest against the Carolina Panthers. Wright remains the odd man out of Miami's backfield rotation as he hasn't registered a rushing attempt so far this season. He remains off the fantasy radar pending an injury to one of Miami's other running backs. Going forward, De'Von Achane will remain Miami's No. 1 running back while Ollie Gordon II backs him up.

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San Francisco 49ers RB Christian McCaffrey was fined $23,186 by the National Football League for using his helmet on an attempted tackle by Jacksonville Jaguars LB Devin Lloyd during the fourth quarter of Week 4's game.

From TheHuddle

New York Giants running back Tyrone Tracy Jr. (shoulder) has officially been ruled out for Sunday's Week 5 tilt on the road against the New Orleans Saints, according to Dan Salomone of Giants.com. New York will be without Tracy for a second straight game due to a dislocated right shoulder that he suffered in the Week 3 loss to the Kansas City Chiefs. The good news is that the 25-year-old was able to practice for the first time on Friday, so he could have a chance to return for a Week 6 divisional clash next Thursday night against the Philadelphia Eagles. In the meantime on Sunday in the Big Easy, rookie Cam Skattebo will be New York's lead back again, and he should be a strong RB2 option with RB1 upside against the winless Saints. Devin Singletary will also have an expanded role for the second straight week. Tracy could be the clear RB2 for the G-Men behind Skattebo when he returns from his shoulder injury.

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Dallas Cowboys running back Miles Sanders (ankle, knee) is officially inactive for the Week 5 game on the road against the New York Jets at MetLife Stadium on Sunday, according to Nick Harris of the Fort Worth Star-Telegram. Sanders came into this game listed as questionable despite not being able to practice all week. With the 28-year-old out of action for the first time this season, rookie Jaydon Blue will suit up for his NFL debut as the backup behind starter Javonte Williams. Although the fifth-round rookie might be eased into the offense in his first regular-season game, Blue is worth stashing in deeper leagues for his upside the rest of the season. It's unclear if Sanders will be able to return in Week 6 against the Carolina Panthers. In addition to Blue, Hunter Luepke could have a bigger role in Dallas' backfield on Sunday behind Williams.

From RotoBaller

With Dallas Cowboys running back Miles Sanders (ankle, knee) ruled out in Week 5 against the New York Jets on Sunday, rookie fifth-rounder Jaydon Blue will be active for his NFL debut at MetLife Stadium, according to Nick Harris of the Fort Worth Star-Telegram. Blue impressed the coaching staff with his playmaking ability during training camp and the preseason, but he was a healthy scratch in each of the first four games of the year. The 21-year-old will get his opportunity in Week 5 with Sanders banged up, although Javonte Williams will most likely remain Dallas' bell-cow back, leaving little work for Blue and Hunter Luepke on Sunday. It's unclear if Sanders will miss time beyond Week 5, but right now, the rookie is merely a bench stash for those with Williams rostered or for fantasy managers hurting at the RB position.

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New Orleans Saints tight end Foster Moreau (knee) is officially active on Sunday and will make his 2025 season debut in Week 5 against the visiting New York Giants, according to Matthew Paras of The New Orleans Times-Picayune. Both Moreau and quarterback/tight end Taysom Hill (knee) are making their season debuts this weekend after they suffered torn ACLs last year. Juwan Johnson has been heavily involved through the first four weeks with Hill and Moreau sidelined, and he should continue to be a big part of their passing attack. The 28-year-old Moreau tore his ACL in Week 18 last year. He should be the TE3 in New Orleans now that he's healthy, which makes him one to avoid in all leagues. Last year, Moreau caught 32 passes for 413 yards and five touchdowns in 17 games.

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The Miami Dolphins have declared QB Quinn Ewers, CB Storm Duck, RB Jaylen Wright, WR Cedrick Wilson and DT Zeek Biggers inactive for Week 5.

From TheHuddle

The New Orleans Saints have declared DT Khristian Boyd, RB Devin Neal, OG Cesar Ruiz, OT Xavier Truss, DE Chase Young and CB Isaac Yiadom inactive for Week 5.

From TheHuddle

Baltimore Ravens safety Kyle Hamilton (groin) and left tackle Ronnie Stanley (ankle) are inactive for Sunday's Week 5 contest against the Houston Texans. Both players had been listed as questionable. Hamilton's absence was widely expected since he didn't practice this past week. Stanley, however, was a little more up in the air after he logged three limited sessions. In the end, though, neither starter will suit up. Baltimore is dealing with plenty of injuries on both sides of the ball, so this news is far from ideal. Reuben Lowery and Sanoussi Kane should earn more snaps at safety while Joseph Noteboom steps up to protect Cooper Rush's blindside.

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New Orleans Saints quarterback/tight end Taysom Hill (knee) is officially active for his 2025 season debut in Week 5 on Sunday against the visiting New York Giants, according to Matthew Paras of The New Orleans Times-Picayune. Hill was activated from the Physically Unable to Perform list on Saturday and will play for the first time this year after suffering a torn ACL in Week 13 of 2024. He will be the backup QB behind starter Spencer Rattler while also serving in his normal gadget role in head coach Kellen Moore's offense. The 35-year-old do-it-all offensive piece will give the Saints offense a boost as they search for their first win of the season, but it's difficult to project how involved he'll be in his first game of the year. Hill is worth a bench stash as a tight end in deeper leagues, but he'll most likely be a boom/bust fantasy asset all year.

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The Houston Texans have declared WR Braxton Berrios, OT Trent Brown, OT Jarrett Kingston, S Zion Childress, LB Christian Harris and QB Graham Mertz inactive for Week 5.

From TheHuddle

The New York Giants have declared QB Jameis Winston, RB Tyrone Tracy Jr., S Demetrius Flannigan-Fowles, DT Elijah Garcia and OG Evan Neal inactive for Week 5.

From TheHuddle

New York Jets running back Kene Nwangwu (hamstring) was downgraded to out ahead of Sunday's Week 5 contest against the Dallas Cowboys. This hardly comes as a surprise after Nwangwu missed all three practices earlier this week. The 27-year-old is headed for his fourth consecutive absence, leaving Isaiah Davis in line to handle kick return duties once again.

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Minnesota Vikings quarterback Carson Wentz (shoulder) injured his left (non-throwing) shoulder late in the first half on Sunday in the Week 5 contest against the Cleveland Browns, but he was able to return for the start of the second half after halftime. With J.J. McCarthy (ankle) inactive again in Week 5, rookie Max Brosmer was Minnesota's next man up if Wentz had been unable to return. Wentz immediately led the Vikings on a touchdown drive to begin the second half, so he appears to be fine to finish off this game, barring another injury. He has gone 10-for-17 in the contest for 112 yards with no touchdowns and no interceptions. So far, Minnesota's only passing touchdown came on a trick play, with running back Cam Akers connecting with tight end Josh Oliver. The Vikings have a bye in Week 6, so it's possible McCarthy will be back under center as the starter in Week 7 versus the Philadelphia Eagles.

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Las Vegas Raiders tight endBrock Bowers(knee) is officially inactive for Sunday's Week 5 contest against the Indianapolis Colts. The star tight end had been listed as questionable, and while head coach Pete Carroll previously expressed optimism about Bowers' status, his knee has not responded well, and he won't be able to suit up this weekend. Bowers is dealing with a PCL injury and a bone bruise, both of which were suffered back in Week 1. He has played through the injury since then, but this week, he was advised to rest until he has recovered. Fantasy managers should look outside Las Vegas for a Week 5 streamer as Bowers' usual replacement, Michael Mayer (concussion), is also inactive. The Raiders will turn to Ian Thomas as their primary tight end this week, but he's not a dependable fantasy option.

From RotoBaller

Las Vegas Raiders tight end Michael Mayer (concussion) is officially inactive for Sunday's Week 5 contest against the Indianapolis Colts. The 24-year-old, who was listed as questionable, has already been sidelined for nearly two full games and will miss at least one more contest. His absence comes at a tough time for the Raiders, who are also without star tight end Brock Bowers (knee). Vegas will turn to Ian Thomas as its primary tight end this week, but he's not a dependable fantasy option.

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Baltimore Ravens wide receiver Devontez Walker (oblique) is officially active for Sunday's Week 5 contest against the Houston Texans. He had been listed as questionable but was trending in the right direction after logging a full practice on Friday. The second-year UNC product has been pretty quiet so far, other than a fluke two-touchdown game back in Week 2. He has just one catch over his last two games and played only seven percent of the offensive snaps last week. He should be avoided in fantasy football as he remains buried behind Zay Flowers, Rashod Bateman, DeAndre Hopkins, and Tylan Wallace.

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New Orleans Saints tight end Juwan Johnson (ankle) is officially active for the Week 5 game on Sunday against the visiting New York Giants after being listed as questionable on the final injury report, according to Matthew Paras of The New Orleans Times-Picayune. Johnson will play on Sunday, but his role could shrink with both Taysom Hill (knee) and Foster Moreau (knee) making their season debuts this weekend. The 29-year-old has been one of quarterback Spencer Rattler's favorite targets through the first four games of the season, catching 22 of his 31 targets for 204 yards and one touchdown. Johnson will have a little more volatility in terms of his weekly production with Hill and Moreau back in the fold, but in a good matchup against New York, Johnson should be considered a low-end TE1/high-end TE2 for fantasy managers in Week 5.

From RotoBaller

ESPN's Adam Schefter reports that Tampa Bay Buccaneers running back Bucky Irving (foot, shoulder), who has already been ruled out for Week 5 against the Seattle Seahawks, is expected to miss at least two weeks. Irving is dealing with a sprained foot and a shoulder injury, with the shoulder injury being the more serious of the two injuries. With Irving out on Sunday against Seattle, it will mean more work for Rachaad White, who will be bumped to RB2 fantasy status with the increase in volume in Tampa's backfield. In addition to White seeing an expanded role, Sean Tucker will also see a boost in the change-of-pace RB2 role behind White. Fantasy managers should have already scooped White up if he was available on the waiver wire in their leagues. If Irving cannot play in Week 6 against the San Francisco 49ers, his next chance to return would be for a Monday night showdown in Week 7 versus the Detroit Lions.

From RotoBaller