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49ers QB Brock Purdy (toe) ruled out vs. Rams

Wed Oct 1 5:06pm ET
Field Level Media

San Francisco 49ers quarterback Brock Purdy will miss Thursday night's showdown against the host Los Angeles Rams due to his turf toe injury.

Purdy missed practice Wednesday for the third straight day.

This will mark Purdy's third absence in four games due to the injury. He was initially hurt during a Week 1 contest against the Seattle Seahawks and aggravated the injury during last week's 26-21 home loss against the Jacksonville Jaguars.

Mac Jones will draw the start for the 49ers (3-1). He started in Weeks 2 and 3 when Purdy was sidelined. Jones injured a knee during Week 3 but is now healthy and was a full practice participant all week.

Receivers Jauan Jennings (ankle/rib), Ricky Pearsall (knee) and Jordan Watkins (calf) and defensive end Robert Beal Jr. (ankle) also were declared out after not practicing this week.

Defensive lineman CJ West (thumb) is questionable. He was a limited participant on Wednesday.

Purdy, 25, has completed 48 of 73 passes for 586 yards, with four touchdowns and four interceptions in his two games as a starter. Jones, 27, is 53-of-80 passing for 563 yards, with four scores and one pick while going 2-0 in his two starts.

San Francisco will be shorthanded in terms of receiving targets as star tight end George Kittle (hamstring) is on injured reserve and standout receiver Brandon Aiyuk (knee) is still recovering from a serious knee injury sustained nearly 12 months ago.

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Player Notes
Brock Bowers Oct 1 9:50pm ET
Brock Bowers

Las Vegas Raiders tight end Brock Bowers (knee) was a limited participant during Wednesday's practice. Fantasy managers shouldn't be too concerned at the moment. The Raiders are just being cautious with their superstar tight end. Right now, there is no reason to believe that Bowers will miss the Week 5 matchup against the Indianapolis Colts. Last week, Bowers hauled in five of his six targets for 46 yards in the loss. The 22-year-old has been held under 50 receiving yards in each of the last three games. Hopefully, Bowers can turn it around this weekend in Indy. Fantasy managers should check back on Thursday and Friday just in case this knee injury does become an issue.

From RotoBaller

Baker Mayfield Oct 1 9:40pm ET
Baker Mayfield

Tampa Bay Buccaneers quarterback Baker Mayfield (knee, biceps) was unable to take the practice field on Wednesday. Mayfield was limited all last week due to a right biceps injury. Now, it appears Mayfield has picked up a knee injury during last week's game against the Philadelphia Eagles. That being said, the Bucs have decided to hold Mayfield out on Wednesday. This is a bit concerning for fantasy managers, but it's probably just the Bucs being cautious with their banged up quarterback. These seem like minor issues that shouldn't cause Mayfield to miss Week 5. However, fantasy managers should check back on Thursday for another update on his status. The absence of Mayfield would likely mean Teddy Bridgewater would start against the Seattle Seahawks in Week 5.

From RotoBaller

David Njoku Oct 1 9:30pm ET
David Njoku

Cleveland Browns tight end David Njoku (knee) was a limited participant during Wednesday's practice session. This shouldn't be too concerning as Njoku also opened last week's practice as limited as well. Despite that, Njoku still played in Week 4, but was held to two receptions for 11 yards. Possibly, the change at quarterback with Dillon Gabriel taking over will help Njoku's value. Fantasy managers shouldn't be too worried about the knee injury at the moment. They should continue to check back throughout the week for more updates. If Njoku sits, Harold Fannin Jr. would see increased snaps in Week 5.

From RotoBaller

Brock Purdy Oct 1 9:20pm ET
Brock Purdy

San Francisco 49ers quarterback Brock Purdy (toe) has already been ruled out for the upcoming Week 5 matchup against the Los Angeles Rams. Purdy made his return to the field last Sunday and looked decent under center. Afterwards, head coach Kyle Shanahan revealed that Purdy is dealing with toe soreness, which is likely related to his turf toe injury. Regardless, there wasn't enough time for Purdy to get ready to play during this Thursday night matchup. The 25-year-old isn't even healthy enough to serve as the emergency backup. The 49ers are fearful that this toe injury could be something that lingers all season long. Fantasy managers better get a viable backup with Purdy already missing three of the first five games of the season. Mac Jones will start under center on Thursday night. Jones has looked solid under center and has some streaming value for this one.

From RotoBaller

Dallas Goedert Oct 1 9:10pm ET
Dallas Goedert

Philadelphia Eagles tight end Dallas Goedert (knee) wasn't able to participate in practice on Wednesday. It's unclear if this is a new knee injury or the same one that kept Goedert sidelined in Week 2. Possibly, Goedert's absence was more rest related than a true knee injury. Fantasy managers should check back on Thursday and Friday to see if Goedert practices. He's coming off a two-touchdown performance in Week 4 and looked completely fine during that game. If he sits, Grant Calcaterra figures to see increased snaps this weekend against the Denver Broncos.

From RotoBaller

Baker Mayfield Oct 1 8:33pm ET
Baker Mayfield

Tampa Bay Buccaneers QB Baker Mayfield (knee, biceps) did not practice Wednesday, Oct. 1.

Fantasy Spin: Mayfield was banged up heading into the Week 4 contest but was able to play. Despite injuries to several key player, he has managed to toss multiple touchdowns in three of the four games this season. He will face a tough test against Seattle in Week 5, but Mayfield should still be in the low-end QB1 mix.

From TheHuddle

Xavien Howard Oct 1 8:33pm ET
Xavien Howard

Indianapolis Colts CB Xavien Howard informed the team that he is retiring from the NFL and later posted a statement on social media.

From TheHuddle

Sterling Shepard Oct 1 8:13pm ET
Sterling Shepard

Tampa Bay Buccaneers WR Sterling Shepard (foot) did not participate in practice Wednesday, Oct. 1. The Buccaneers only held a walkthrough Wednesday, so this is an estimation.

Fantasy Spin: Shepard's availability for Week 5 will not be known until later in the week, so fantasy players can check on his status in a few weeks. He had a good game a few weeks ago but has been held to under 40 yards in three of the four games this season. He will see a few targets if he plays but can be avoided in fantasy leagues.

From TheHuddle

Chris Godwin Oct 1 8:13pm ET
Chris Godwin

Tampa Bay Buccaneers WR Chris Godwin (ankle) fully participated in practice, Wednesday, Oct. 1. The Buccaneers only held a walkthrough Wednesday, so this is an estimation.

Fantasy Spin: Godwin made his season debut last week but was only able to catch three of his 10 targets during the game. He seems like he will be an important part of the passing game right away and should see a good amount of targets again this week. He can be considered a No. 2 or No. 3 receiver in fantasy leagues.

From TheHuddle

Michael Carter Oct 1 8:10pm ET
Michael Carter

Arizona Cardinals running back Michael Carter told Cardinals' beat reporters on Wednesday that he will be starting at running back in Sunday's game against the Titans. Carter wasn't explicitly asked if he was going to start, but he indirectly said it when answering a question about the rollercoaster of a year he's had. There was plenty of intrigue and uncertainty around Arizona's backfield following Trey Benson (knee) surprisingly being placed on IR. Some assumed that Emari Demercado would operate as the primary back after seeing most of the snaps in Benson's absence last week against the Seahawks. But Demercado played primarily in his normal role on special teams and on pass downs as the Cardinals were in comeback mode. Carter doesn't play special teams and was inactive for the first three games, then played only four snaps last week. He operated as a lead back late last season when all the Arizona backs were hurt, and it looks like he'll get another opportunity. Carter feels like an RB that fantasy managers can pick up and then plug and play into their lineup this week as he gets a dream matchup against the lowly Titans.

From RotoBaller

Lavonte David Oct 1 8:03pm ET
Lavonte David

Tampa Bay Buccaneers CB Jamel Dean (hip), WR Mike Evans (hamstring), DT Greg Gaines (pectoral), RB Bucky Irving (foot, shoulder), S Christian Izien (quadriceps), QB Baker Mayfield (biceps, knee), CB Benjamin Morrison (hamstring), WR Sterling Shepard (foot) and S Tyreke Smith (ankle) did not participate in practice Wednesday, Oct. 1. LB Lavonte David (knee), DE Logan Hall (groin), LB Haason Reddick (neck) and OT Tristan Wirfs (knee) were limited during practice. WR Chris Godwin (ankle), OT Charlie Heck (knee) and CB Zyon McCollum (thumb) fully participated in practice. The Buccaneers only held a walkthrough Wednesday, so the report is an estimation.

From TheHuddle

Mike Evans Oct 1 8:03pm ET
Mike Evans

Tampa Bay Buccaneers WR Mike Evans (hamstring) did not participate in practice Wednesday, Oct. 1. The Buccaneers only held a walkthrough Wednesday, so this is an estimation.

Fantasy Spin: Evans was expected to miss several weeks because of his hamstring injury, so he seems unlikely to be available for Week 5. Fantasy players can check on his status later in the week but should look for other options to use.

From TheHuddle

Terrance Ferguson Oct 1 8:00pm ET
Terrance Ferguson

Los Angeles Rams rookie tight end Terrance Ferguson has been working primarily with the scout team during practice and has caught the eye of offensive coordinator Mike LaFleur. LaFleur talked about how even though he has just been running on the scout team, they are always watching and evaluating as a staff. He specifically noted a moment when Ferguson went immediately to veteran tight end Tyler Higbee after a scout team rep to ask for feedback and what he saw on the play. LaFleur seemed encouraged by the growth and accountability that he displayed in that setting. The 2025 second-round pick has been active for two of four games and has played almost exclusively special teams with just four offensive snaps all season. Ferguson should still be well-regarded in dynasty leagues, but he's nowhere near relevancy in redraft leagues.

From RotoBaller

Calvin Ridley Oct 1 7:53pm ET
Calvin Ridley

Tennessee Titans OG Blake Hance (shoulder), OT JC Latham (hip), WR Bryce Oliver (knee) and WR Calvin Ridley (elbow, knee) did not participate in practice Wednesday, Oct. 1. S Mike C. Brown (knee), DE James Lynch (shoulder), RB Tony Pollard (non-injury), DT Jeffery Simmons (non-injury), RB Tyjae Spears (ankle), S Kevin Winston Jr. (hamstring) and OG Kevin Zeitler (foot) were limited during practice.

From TheHuddle

Calvin Ridley Oct 1 7:43pm ET
Calvin Ridley

Tennessee Titans WR Calvin Ridley (elbow, knee) did not participate in practice Wednesday, Oct. 1.

Fantasy Spin: Fantasy players will need to monitor the situation to see if Ridley will be available for Week 5. He has been held to 30 yards or less in three of the four games this season and can be avoided by players if better options are available.

From TheHuddle

Sean Tucker Oct 1 7:40pm ET
Sean Tucker

Tampa Bay Buccaneers running back Sean Tucker could have an opportunity for more work in Week 5 if star Bucky Irving ends up being ruled out. Tucker said that he's "always ready and prepared" when asked if he would be ready to take on a bigger role on Sunday. Tucker has proven that to be true in the limited sample where he has gotten a decent number of touches. In a game against New Orleans last season that Rachaad White missed with injury, Tucker totaled 191 yards and two touchdowns. Additionally, he has six career games with at least five carries. He's averaging over five yards per carry across those games. Rachaad White would be likely to handle the bulk of the work if Irving were to miss, but Tucker could mix in and steal some touches because he is the better runner. He's a decent stash ahead of Week 5 as more news trickles out.

From RotoBaller

Keenan Allen Oct 1 7:33pm ET
Keenan Allen

Los Angeles Chargers WR Keenan Allen (non-injury) did not participate in practice Wednesday, Oct. 1.

Fantasy Spin: Allen has caught at least five passes in every game this season but is coming off a season-low 37 yards in Week 4. He seems to be a popular target for Justin Herbert this season and be a No. 2 receiver in fantasy leagues.

From TheHuddle

Keenan Allen Oct 1 7:33pm ET
Keenan Allen

Los Angeles Chargers WR Keenan Allen (non-injury), OT Joe Alt (ankle) and WR Derius Davis (knee) did not participate in practice Wednesday, Oct. 1. OG Mekhi Becton (concussion), TE Will Dissly (knee), S Derwin James (glute) and CB Tarheeb Still (ankle) were limited during practice. C Andre James (neck) fully participated in practice.

From TheHuddle

KaVontae Turpin Oct 1 7:30pm ET
KaVontae Turpin

Dallas Cowboys wide receiver KaVontae Turpin (foot) could wind up missing Sunday's game against the Jets after suffering a foot injury in the Cowboys' tie against the Packers in Week 4. Turpin was not present for practice on Wednesday, but, positively, the Cowboys don't think that this is an injury that would require a trip to the Injured Reserve list. Dallas is already down their superstar wide receiver CeeDee Lamb, and that receiver room was not very deep to begin with. Turpin was off to a productive start to 2025, catching 11 of 13 targets for 159 yards and a touchdown. This is the second time this year that Turpin has been banged up, hurting his neck in Week 2 against the Jets and not returning. He ended up playing in Week 3, but it may not be the same case this week with a new injury. More targets will be directed George Pickens' way, and maybe we will see rookie Jaydon Blue active for the first time this season to mirror Turpin's skillset.

From RotoBaller

Zay Jones Oct 1 7:23pm ET
Zay Jones

Arizona Cardinals OT Kelvin Beachum (non-injury) and DE Darius Robinson (pectoral) did not participate in practice Wednesday, Oct. 1. OG Evan Brown (hamstring), WR Greg Dortch (collarbone), WR Simi Fehoko (concussion), OG Jon Gaines II (finger), OG Will Hernandez (knee), CB Will Johnson (groin), WR Zay Jones (concussion) and DT Bilal Nichols (neck) were limited during practice.

From TheHuddle