Carolina Panthers (0-2) vs. Atlanta Falcons (1-1)

Sunday, 1 p.m. ET

FanDuel odds: Falcons -5.5, Total 43.5

Series Rewind: The NFC South foes have split their two-game series every season since 2020. But the home team has taken four of the past six games.

The Falcons got their first win of the season on "Sunday Night Football" last week but coach Raheem Morris wants them to treat every week like a prime-time show. The Panthers may not be the most inspiring opponent, but Carolina is preparing for its home opener after losses at Jacksonville and Arizona and scored an overtime win over Atlanta to end the 2024 season. Falcons quarterback Michael Penix Jr. threw for 312 yards against Carolina in last year's regular-season finale. Running back Bijan Robinson is second in the league with 292 yards from scrimmage (167 rushing, 125 receiving), and Morris dubbed Robinson "definitely the best player in football." Carolina QB Bryce Young had the best game of his NFL career the last time he played the Falcons, completing 73.5 percent of his passes for 251 yards with three passing touchdowns and two rushing scores. Carolina is re-tooling its offensive front with two starting linemen going on IR: Cade Mays is shifting to center, while Chandler Zavala will start at right guard. The Falcons need a replacement for cornerback A.J. Terrell Jr. (hamstring), who's considered week-to-week.

Green Bay Packers (2-0) at Cleveland Browns (0-2)

Sunday, 1 p.m. ET

FanDuel odds: Packers -7.5, Total 41.5

Series Rewind: This is the first meeting since the Packers beat Cleveland 24-22 in 2021. Green Bay has won six of the past seven meetings.

Cleveland has yet to force a turnover and Green Bay hasn't coughed one up, but Browns defensive coordinator Jim Schwartz geared the team up for plentiful chances to get their hands on the ball on Sunday. The Packers were aggressive pushing the ball down the field last week to beat Washington, and head coach Matt LaFleur surely took note of Lamar Jackson's nine completions (and 14 attempts) on passes of at least 15 yards in the air. Green Bay is down one favored target in Jayden Reed (foot, clavicle surgeries) but fellow wide receiver Romeo Doubs and emerging standout Dontayvion Wicks (all six of his catches resulted in first downs) are more than adequate if TE Tucker Kraft is held out. Kraft underwent tests Thursday after a knee injury in practice but said he's OK. The Browns share the NFL lead in pass attempts at 90 and found themselves in hurry-up, comeback mode at Baltimore last week when QB Joe Flacco flipped a pair of costly interceptions. Flacco has two touchdowns and three interceptions this season with two rookies leading the way. TE Harold Fannin has 12 receptions for 111 yards and RB Dylan Sampson has 11. Finding a way to slow down pass rushers Micah Parsons (Packers) and Myles Garrett (Browns) is imperative and no easy task for offensive lines dealing with injuries. Garrett leads the NFL with six tackles for loss and is tied for the league lead with 3.5 sacks.

New England Patriots (1-1) vs. Pittsburgh Steelers (1-1)

Sunday, 1 p.m. ET

FanDuel odds: Steelers -1.5, Total 44.5

Series Rewind: The regular-season series is knotted up 15-15 entering this weekend, but the Patriots have gotten the better of Pittsburgh in seven of their past eight meetings. The Steelers haven't left Foxborough with a victory since 2008.

New England is coming off a 33-27 victory over Miami last week and will be attempting to win back-to-back games for the first time since the 2022 season. That was long before coach Mike Vrabel's tenure, and he said he's neither familiar nor concerned with that recent history. Drake Maye threw for 230 yards and two scores against Miami, and Rhamondre Stevenson led the Patriots in both rushing (54 yards) and receiving (88). The Steelers, for their part, are coming off a 31-17 defeat to Seattle; they gave up more than 30 points in each of the first two games and rank 28th in the league in run defense (299 yards allowed). Their defense could be missing linebacker Alex Highsmith (ankle), cornerback Joey Porter Jr. (hamstring) and safety DeShon Elliott (knee), who have not practiced this week. Patriots cornerback Christian Gonzalez practiced this week for the first time since sustaining a hamstring injury July 28.

Los Angeles Rams (2-0) at Philadelphia Eagles (2-0)

Sunday, 1 p.m. ET

FanDuel odds: Eagles -3.5, Total 44.5

Series Rewind: Saquon Barkley wrecked the Rams last season, rushing for a franchise-record 255 yards and two TDs in a Week 12 win in Los Angeles and 205 yards and two TDs in a divisional playoff win.

Barkley is off to a modest start this year and the reigning NFL Offensive Player of the Year will try to jump-start the defending champion Eagles' humdrum offense in a matchup of NFC unbeatens. QB Jalen Hurts scored a tush-push TD in the Week 2 win at Kansas City but is still looking for his first scoring pass of 2025, while wideouts A.J. Brown and DeVonta Smith have been underused. DT Jalen Carter (shoulder) is good to go. Rams QB Matthew Stafford needs one passing TD to tie Matt Ryan (381) for ninth place in NFL history. RB Kyren Williams has gained 50-plus scrimmage yards in 30 straight games, the longest active streak in the NFL. Six-time Pro Bowl WR Davante Adams recorded his first 100-yard game and first TD with the Rams in last week's win against the Titans. LB Jared Verse sacked Hurts twice in January's playoff loss.

Jacksonville Jaguars (1-1) vs. Houston Texans (0-2)

Sunday, 1 p.m. ET

FanDuel odds: Jaguars -1.5, Total 44.5

Series Rewind: The Texans have won their last seven games at Jacksonville and won 12 of the last 14 in the AFC South matchup. The Jaguars last beat them at home in 2017 and have won just three of their last 15 home games against Houston.

With two losses by a combined six points, the Texans have dug themselves an early hole in the division as they look to win the AFC South Division for the third straight year. With a depleted receiver room, third-year QB CJ Stroud has gotten off to a slow start with one touchdown and one interception in two games. Maybe a game against Jacksonville, who he has thrown for more yards against (1,171) than any other team, is what he needs to wake up. The Jags have never intercepted Stroud in four games, but lead the league in picks (five) this year. They're also leading the league in rushing yards (169.5 per game) and fourth in total offense (389.0), anchored by RB Travis Etienne, who ranks second in the league with 214 rushing yards. Dyami Brown is the only Jaguars WR with 100 receiving yards this season, as Brian Thomas Jr. (five catches on 19 targets) is off to a slow start to Year 2. He was limited in Thursday's practice due to a wrist injury.

Tennessee Titans (0-2) vs. Indianapolis Colts (2-0)

Sunday, 1 p.m. ET

FanDuel odds: Colts -4.5, Total 43.5

Series Rewind: Third-year Indianapolis head coach Shane Steichen is 4-0 vs. Tennessee entering this week's matchup. The Colts lead the all-time series 39-22. The Titans are 7-16 at home vs. the Colts since the franchise moved to Tennessee in 2002.

The Colts are probably the biggest positive surprise of the season at 2-0 for the first time since 2009 while becoming the first team in the Super Bowl era to not punt during their first two games. QB Daniel Jones, tossed aside by the Giants, has looked like a new man, with 588 yards, two touchdowns and no picks in his first two games. Teams have been slow to figure out blitzing Jones is not the answer. He has been blitzed on 50 of his 63 pass attempts, posting a QB rating over 110 when the Broncos and Dolphins sent an extra rusher. Vacating spots in the back seven is also clearing lanes for RB Jonathan Taylor. He had 165 rushing yards last week and leads the league with 236 in two games. Titans QB Cam Ward is the first No. 1 overall pick in NFL history to throw no interceptions in his first two starts. However, he has just 287 yards, one touchdown and has been sacked a league-worst 11 times. He may again be under siege this week as RT J.C. Latham (hip) and RG Kevin Zeitler (bicep) aren't fully healthy. Jones' favorite weapon so far has been rookie TE Tyler Warren, who leads the team with 11 catches and is tops for all NFL tight ends with 90 yards after the catch.

New York Jets (0-2) at Tampa Bay Buccaneers (2-0)

Sunday, 1 p.m. ET

FanDuel odds: Buccaneers -6.5, Total 44.5

Series Rewind: Tampa Bay is 2-0 for the fifth straight season but is looking for its first 3-0 start since 2005.

Healthy doesn't describe either squad three weeks into the regular season. The Buccaneers have notched two comeback wins, including a 20-19 road victory over the host Houston Texans on Monday night. Quarterback Baker Mayfield guided that comeback and he has thrown five touchdown passes without an interception in 70 attempts this season. Mayfield is bothered with foot and toe injuries and has practiced, but his bodyguards are not in great shape. The right side of the offensive line is beat up. Guard Cody Mauch (season-ending knee) and tackle Luke Goedeke (foot) were placed on injured reserve. The Jets have to lean on veteran journeyman Tyrod Taylor to start this week. Quarterback Justin Fields (concussion) has been ruled out. New York is averaging just 274 yards per game, 26th in the NFL. New coach Aaron Glenn was the defensive coordinator of the Detroit Lions for the past four seasons but the Jets have allowed 30 or more points in each of his first two games.

Cincinnati Bengals (2-0) at Minnesota Vikings (1-1)

Sunday, 1 p.m. ET

FanDuel odds: Vikings -3, Total 42.5

Series Rewind: The home team has won 14 of the past 15 games between these teams.

Ja'Marr Chase and Justin Jefferson can't fight over Joe Burrow this week. The former LSU receivers take center stage with an air of uncertainty with backup quarterbacks stepping in this week. Jake Browning took the reins when Burrow went down with a turf toe injury in Week 2 and beat the Jaguars (31-27) by guiding a game-winning drive in the fourth quarter. He also was intercepted three times and lacks Burrow's pocket agility behind a ragtag offensive line sure to be under siege by the blitz-heavy scheme of coordinator Brian Flores. The Vikings are rolling with Carson Wentz, a North Dakota State product and former No. 2 overall pick making NFL history with a start for his sixth team in six seasons. Wentz was a late add to the Vikings' roster to be the backup to J.J. McCarthy, who likely will miss more than one week with a high ankle sprain. Coach Kevin O'Connell has been down this road more often than he'd like since Kirk Cousins ruptured his Achilles in 2023. A gift of upgraded protection could be waiting for Wentz after LT Christian Darrisaw (knee) practiced this week. He was held out of the first two games to focus on his recovery from a season-ending knee injury last October.

Los Vegas Raiders (1-1) at Washington Commanders (1-1)

Sunday, 1 p.m. ET

FanDuel odds: Commanders -3.5, Total 44.5

Series Rewind: Washington has won four of the past five games in the series with the Raiders, most recently a 17-15 victory in 2021. The starting quarterbacks were Taylor Heinecke (Washington) and Derek Carr.

There's a strong possibility Marcus Mariota is the Commanders' signal caller. Jayden Daniels injured his knee in a 27-18 loss to the Green Bay Packers on Sept. 11 and head coach Dan Quinn wants to play it safe in another matchup with his former boss in Seattle, Pete Carroll. Mariota has plenty of experience and has started 74 regular-season games in his career. Mariota played two seasons (2020-21) with the Raiders so there surely is some familiarity remaining despite Las Vegas now having Carroll on the sideline. The Raiders are coming off a 20-9 loss to the Los Angeles Chargers when Daniel Carlson's three field goals accounted for all the points. New quarterback Geno Smith was intercepted three times while throwing for 180 yards. Smith has thrown a league-worst four picks. Star tight end Brock Bowers played through a tender knee and had just 38 receiving yards on a night in which Las Vegas had just 218 as a team. Prized rookie running back Ashton Jeanty (81 yards on 30 carries) is finding the NFL is a bit tougher than the Mountain West.

Denver Broncos (1-1) at Los Angeles Chargers (2-0)

Sunday, 4:05 p.m. ET

FanDuel odds: Chargers -2.5, Total 45.5

Series Rewind: The Chargers swept the Broncos last season, winning both meetings by a touchdown, but Denver has had more success in the series, with a 72-57-1 edge all-time.

The Chargers are out for a clean sweep of the AFC West through three games. Los Angeles beat the Chiefs in Brazil to open the season, and a shorthanded defense stepped up to dominate the Raiders 20-9 in Las Vegas on Monday. Justin Herbert (560 yards, five TDs, zero interceptions) has been stellar through two games and Daiyan Henley -- limited by an illness -- led the D against Las Vegas with an interception, a sack and 10 tackles. The Chargers are alone atop the division for the first time since 2021, while the Broncos missed a chance to go 2-0 against the Colts. Bo Nix was solid before throwing a fourth-quarter interception, and the Broncos were called for a leverage penalty when the Colts missed a field goal to end the game, giving Indianapolis a second chance to convert the game-winner. Broncos tight end Evan Engram (back) and linebacker Dre Greenlaw (quad) haven't practiced this week, nor have Chargers tight end Will Dissly (knee) or defensive back Elijah Molden (hamstring).

New Orleans Saints (0-2) at Seattle Seahawks (1-1)

Sunday, 4:05 p.m. ET

FanDuel odds: Seahawks -7.5, Total 41.5

Series Rewind: The Saints have won six of the past seven meetings with the Seahawks.

Spencer Rattler is the 0-8 as a starter with the Saints, but he's had New Orleans in position to win each of the first two weeks in defeats decided on the final possession. The last quarterback to start their career with nine consecutive losses was DeShone Kizer (2007, Browns). To avoid the history books, Rattler has the challenge of solving the Mike Macdonald defense that beat up and baffled Aaron Rodgers last week. It's a homecoming for Saints coach Kellen Moore and rookie first-round pick Taliese Fuaga, who grew up 30 miles from Lumen Field as a Seahawks fan. Moore hails from Prosser, Wash., and has a large following from neighboring Idaho because of his success as a quarterback at Boise State. Seattle is making every effort to rekindle home dominance from yesteryear but the Seahawks lost at home Week 1 and won only three times there last season. Getting more out of the offense is the thrust this week for Seattle. The Seahawks got their new-look offense on track last week, gaining 395 yards against the Steelers. Sam Darnold threw for 295 yards and two touchdowns, while Kenneth Walker III rushed for 105 yards and a TD -- his first 100-plus yard game on the ground since the 2024 season opener.

Dallas Cowboys (1-1) at Chicago Bears (0-2)

Sunday, 4:25 p.m. ET

FanDuel odds: Cowboys -1.5, Total 50.5

Series Rewind: A win might be vital for Dallas this week. Over the past 10 seasons, only four teams with first-year head coaches have made the playoffs after a 1-2 start.

Brock Hoffman isn't a household name, but he might be a make-or-break linchpin for the Cowboys. He steps in for injured center Cooper Beebe starting Sunday charged with keeping the Cowboys' offense chugging after a 40-point outburst last week to beat the Giants in overtime. Dallas has been more balanced out of the gate, which head coach Brian Schottenheimer credits to the performance of his overhauled offensive line. Beebe made two second-effort blocks last week that saved heavy pressure or big hits on QB Dak Prescott, who is on a heater of sorts. A knife through butter on third down this season, Prescott is 15-of-20 passing with 11 moving the chains. He leads the league in both categories. That's not great news for Chicago and a secondary fighting injuries. The Bears rolled back home licking their wounds after giving up 52 points to the Lions in a shellacking at Detroit. But the Cowboys' defense is coming off a rough outing as well. The Giants had 350 passing yards and three touchdowns, and Dallas is surrendering first downs on 52 percent of opponent third-down tries. QB Caleb Williams has directed the offense on opening-drive touchdowns in both games this season. He'll be staring across the line at a group coordinated by former Bears coach Matt Eberflus this week.

Arizona Cardinals (2-0) at San Francisco 49ers (2-0)

Sunday, 4:25 p.m. ET

FanDuel odds: 49ers -1.5, Total 44.5

Series Rewind: Not many teams are less excited for the Christian McCaffrey experience than the Cardinals. The 49ers' do-it-all back had over 100 rushing yards and 175 yards from scrimmage yards with seven TDs in two meetings in 2023, but missed both games with Arizona last season. He had at least 100 yards from scrimmage in six of seven career games against the Cardinals.

Quarterback Brock Purdy missed Week 2 with a toe injury, but the 49ers had enough to sink the Saints behind McCaffrey and Mac Jones. Jones threw three TD passes and had a passer rating over 113. McCaffrey is the 49ers' leading receiver (15) and rusher (124 yards) but San Francisco has had success with Jauan Jennings in the slot in this matchup. He had 12 receptions in two games vs. Arizona last season. QB Kyler Murray has the Cardinals undefeated and threw four TDs in a 47-24 dismantling of injury-ravaged San Francisco in the season-ending matchup last season. Murray is aided by a running game that finished in the top 10 the past two seasons. RB James Conner has been largely held in check with 73 yards on 23 carries. Greybeard defensive end Calais Campbell had 2.0 sacks last week to become the fourth player since 1982 with multiple sacks in a game at age 39-plus (James Harrison, Clay Matthews, Bruce Smith).

Kansas City Chiefs (0-2) at New York Giants (0-2)

Sunday, 8:20 p.m. ET

FanDuel odds: Chiefs -5.5, Total 44.5

Series Rewind: The home team has won four of the past five meetings between these teams.

Patrick Mahomes is part of a 0-2 team for the first time in eight seasons as an NFL starting quarterback. The Chiefs are in unfamiliar territory -- last place in the AFC West. The last time Kansas City started a season with consecutive losses was 2014 when Mahomes was a freshman quarterback at Texas Tech. The three-time Super Bowl winner has just 445 yards and one touchdown through two games as the Chiefs deal with challenges in the passing game involving wideouts Rashee Rice (suspension) and Xavier Worthy (shoulder) and tight end Travis Kelce, who is showing his age. The most recent loss at home last week to the Philadelphia Eagles (20-17) in a Super Bowl rematch revealed flaws in the running game, where Mahomes has been the only consistent threat. The Giants were part of an entertaining effort while falling 40-37 in overtime to the Dallas Cowboys in Week 2. Russell Wilson passed for 450 yards, three touchdowns and one interception one week after being criticized for a poor debut with the club in a 21-6 loss to the Washington Commanders. The Giants are tied for 27th in scoring defense (30.5 points per game) and are dead last in total defense (455.0 yards per game). New York standout left tackle Andrew Thomas (foot) could make his season debut.

Detroit Lions (1-1) at Baltimore Ravens (1-1)

Monday, 8:15 p.m. ET

FanDuel odds: Ravens -5.5, Total 52.5

Series Rewind: It's "Monday Night Football" so you know Lamar Jackson is excited about stepping on the field. The Baltimore quarterback has dazzled on Monday nights throughout his career and has 22 passing touchdowns without being intercepted in nine Monday night appearances.

Jackson has twice thrown five touchdown passes and also had four touchdowns through the air when he set the franchise record of 442 passing yards against the Indianapolis Colts in 2021. There should be a lot of points scored in this matchup. The Ravens lead the NFL in scoring average (40.5) and have reached the 40-point mark in both of their games. Detroit ranks third in scoring (32.5) and is coming off a 52-21 whipping of the Chicago Bears in Week 2. Lions quarterback Jared Goff matched his career best of five passing touchdowns while hitting 23 of 28 throws for 334 yards. It was the fifth career start with his team scoring at least 50 points, tied with Pro Football Hall of Famer Peyton Manning (five) for the fourth-most five-TD passing games since 1950, behind Tom Brady (eight starts), Drew Brees (six) and Len Dawson (six). Detroit wideout Amon-Ra St. Brown has caught 13 passes for 160 yards and is tied for the NFL lead with three touchdown receptions. The Lions are seeking to end a five-game skid against Baltimore.