San Francisco 49ers running back Christian McCaffrey handled another massive workload in Monday night's 20-9 win over the Carolina Panthers, recording 24 carries for 89 yards and a touchdown to go with seven catches (seven targets) for 53 yards in the pass game. McCaffrey now has 298 touches on the season after another 31 in Week 12 against his former team, with Jonathan Taylor being the next closest player at 237. The superstar running back also leads the league in receptions with 81. McCaffrey continues to be one of the top options in all of fantasy football as the engine of San Francisco's offense and a security blanket for quarterback Brock Purdy, who struggled throwing downfield in this game with three interceptions in the first half. McCaffrey will rank as an elite RB1 in Week 13 against the Cleveland Browns.

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Chicago Bears rookie first-round tight end Colston Loveland had his breakout game in the Week 9 win over the Cincinnati Bengals, catching six of his seven targets for a season-high 118 yards and the first two touchdowns of his career. The 10th overall pick out of Michigan hasn't come close to matching that type of production in three games since, but he did manage to find the end zone for the third time this year in Sunday's three-point win over the Pittsburgh Steelers, catching four of five targets for 49 yards. The 21-year-old was second on the team in catches and third in receiving yardage on the day as he continues to see his role increase in the second half of the year. In the last three weeks going into Week 12, Loveland was a top-five fantasy TE in half-PPR scoring. Loveland and the Bears have a bad matchup in Week 13 on Black Friday against Philly, but Loveland should be a waiver-wire target for those searching for an upgrade at the position. He's rostered in only 43% of Yahoo leagues.

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Kansas City Chiefs running back Isiah Pacheco (knee) is targeting a return to the lineup this Thursday against the Dallas Cowboys on Thanksgiving Day in Week 13, a source told ESPN's Jeremy Fowler. Pacheco has been out with a sprained MCL in his knee since Week 8 (he's missed the last three games), but he was listed as a full participant on Monday's estimated injury report and looks to be trending in the right direction to suit up in Dallas. Veteran Kareem Hunt, who had a season-high 30 carries for 104 rushing yards and a touchdown in Sunday's overtime win over the Indianapolis Colts, should continue to be KC's preferred option out of the backfield against the Cowboys, making the 26-year-old Pacheco not much more than a shaky, low-upside, touchdown-dependent RB3/flex for fantasy managers. When healthy, Pacheco's volume has taken a hit in 2025, and he has only 329 rushing yards and one TD in his eight games played.

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New Orleans Saints tight end Juwan Johnson isn't the sexiest name by any means at his position, primarily because he resides in a Saints offense that is tied for last in the league with 15 points scored per game. However, Johnson has been the No. 2 option in the passing game in New Orleans in 2025 behind receiver Chris Olave, and he enters Week 13 action tied with Hunter Henry at 8.7 half-PPR fantasy points per contest. The 29-year-old had touchdown catches in back-to-back games going into the Week 12 loss to the Atlanta Falcons, including a season-high 92 receiving yards before the team's Week 11 bye. On Sunday, Johnson had six catches (second-most in a game this year) on seven targets for 46 yards against Atlanta. His 67 targets through 11 games in 2025 tie him for seventh at the TE position. Johnson will be in position as an intriguing low-end TE1 in fantasy in a plus matchup this weekend versus Miami. He is on pace for a career-best season.

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In his first game since suffering a hip injury in Week 5 that landed him on Injured Reserve, Jacksonville Jaguars tight end Brenton Strange recorded five catches for 93 yards on five targets in his team's Week 12 win over the Arizona Cardinals. Strange's encouraging return was a continuation of what he had shown before getting hurt. Across the four full games he played before the hip injury, Strange had recorded 19 receptions for 182 yards on 23 targets. Jacksonville could get wide receiver Brian Thomas Jr. (ankle) back from injury in Week 13 against the Tennessee Titans, which may impact the target share for Strange. However, Strange himself played just 71% of the Jaguars' offensive snaps in Week 12, which is a number that could rise as he gets fully healthy and re-integrated into the offense. Strange should be a waiver-wire target in fantasy leagues with 12 or more teams heading into Week 13.

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Houston Texans wide receiver Christian Kirk had his best game of the 2025 season in Week 12, recording five catches for 54 yards and a touchdown on six targets against the Buffalo Bills. It's been an injury-marred season for Kirk overall, as he's recorded 21 catches for 198 yards and a touchdown across seven games played. However, Kirk has earned 21 targets over the last four weeks and could be re-establishing himself as a steady presence in the slot for the Texans. The 29-year-old has typically been a fairly productive wide receiver when healthy, averaging 6.6 targets and 53.7 receiving yards per game across 100 career NFL contests. In PPR fantasy leagues with 12 or more teams, Kirk could be worth targeting on the waiver wire heading into a Week 13 matchup against the Indianapolis Colts.

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Tampa Bay Buccaneers wide receiver Tez Johnson was one of the lone bright spots for his team in their 34-7 Week 12 loss to the Los Angeles Rams, hauling in three catches for 21 yards and a touchdown on four targets. The 23-year-old has now recorded five touchdown catches over his last six games played. Perhaps most encouragingly, Johnson played 86% of Tampa Bay's offensive snaps against Los Angeles even though Buccaneers wideout Chris Godwin returned to the field for the first time since Week 5. However, Bucs quarterback Baker Mayfield (shoulder) suffered a shoulder injury that forced him to exit Week 12 early and puts his status in question for Tampa Bay's Week 13 matchup against the Arizona Cardinals. Any missed time for Mayfield would be a blow to the fantasy outlook for Johnson and the rest of the Buccaneers' pass-catchers. Still, Johnson has emerged as a player worth targeting on the waiver wire in PPR leagues with 12 or more teams.

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With Jacksonville Jaguars wide receivers Travis Hunter (knee) and Brian Thomas Jr. (ankle) sidelined in recent weeks, Parker Washington has stepped up as one of the go-to targets for Jaguars quarterback Trevor Lawrence. Over his last four games, Washington has hauled in 18 receptions for 213 yards and two touchdowns on 25 targets. Thomas Jr. could return as soon as Week 13, but Hunter is on Injured Reserve and is not expected to return this season. Even when Thomas Jr. returns to the lineup, Washington could remain a relatively high-volume option in the Jacksonville passing game. Across 11 games this season overall, the 23-year-old has hauled in 35 receptions for 421 yards and three touchdowns on 60 targets. In fantasy leagues with 12 or more teams where Washington remains available, he could be worth targeting on the waiver wire heading into a Week 13 matchup against the Tennessee Titans.

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New York Giants tight end Theo Johnson recorded three catches for 77 yards on three targets in his team's Week 12 overtime loss to the Detroit Lions. Across 12 games this season, the 24-year-old has hauled in 39 receptions for 427 yards and five touchdowns on 60 targets. While Johnson's numbers don't jump off the page, he's been extremely consistent. In his last six games, Johnson has recorded exactly three receptions five times. The Giants may be getting starting quarterback Jaxson Dart (concussion) back in Week 13 after he's missed each of their last two games due to a concussion. Across Dart's last four games before getting injured, he targeted Johnson 25 times. He lacks explosive upside, but Johnson has proven to be a high-floor fantasy tight end option who should be a waiver-wire target in leagues with 12 or more teams heading into a Week 13 matchup against the New England Patriots.

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Across the first 10 games of his NFL career, Chicago Bears rookie wide receiver Luther Burden III has recorded just 22 receptions for 295 yards and one touchdown on 28 targets. However, Burden III has been playing some of his best football in recent weeks. Over his last three outings, the 21-year-old has hauled in nine catches for 124 yards on 13 targets. Perhaps most importantly, Burden III could be overtaking Bears veteran Olamide Zaccheaus for the WR3 role in Chicago alongside Rome Odunze and DJ Moore. Over the last two weeks, Burden III has earned 66 offensive snaps compared to just 33 for Zaccheaus. The presence of Odunze and Moore caps Burden III's upside. Still, the rookie has flashed big-play ability and appears to be carving out a more stable playing time floor. Burden III should be a waiver-wire target in fantasy leagues with 12 or more teams heading into a Week 13 matchup with the Philadelphia Eagles.

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Jacksonville Jaguars running back Bhayshul Tuten was unable to find much success in the running game during Sunday's game against the Arizona Cardinals. Tuten rushed the ball seven times for 17 yards in the overtime victory. It's worth noting that Tuten did carry an ankle injury into this game, so possibly that impacted his performance on the field. In Week 11, Tuten rushed for 74 yards with a touchdown in the win over the Los Angeles Chargers. The rookie back remains the backup, but should continue seeing nearly double digit carries per week. His struggles this week could make fantasy managers hesitant, but he does head into a plus matchup against the Tennessee Titans in Week 13.

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Dallas Cowboys wide receiver KaVontae Turpin (shoulder, illness) was listed as a non-participant during Monday's practice session. Turpin played his highest snap count since Week 4 during Sunday's win over the Philadelphia Eagles. It appears the 29-year-old picked up a pair of issues along the way. He'll get a few more days to get healthy before Thursday's Thanksgiving matchup against the Kansas City Chiefs. The absence of Turpin could mean more playing time for Jalen Tolbert, who was a healthy scratch this past weekend.

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Baltimore Ravens safety Kyle Hamilton (ankle) has a chance at suiting up against the Cincinnati Bengals during Thursday's Thanksgiving matchup. Hamilton was already playing through a shoulder issue, but suffered an ankle injury during Sunday's win over the New York Jets. Despite the pair of injuries, Hamilton does have a chance at playing on this short week. His absence would be a tough blow to this defense in what could already be a high-scoring affair between these two squads. Hamilton sat out during Monday's estimated practice, but has a few more chances to get ready to play.

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Cleveland Browns quarterback Dillon Gabriel will serve as the backup option for the upcoming Week 13 matchup against the San Francisco 49ers. Gabriel sat out of Sunday's game versus the Las Vegas Raiders due to a concussion. On Monday, Gabriel cleared concussion protocol, but was named the backup for at least one game. Shedeur Sanders played well in his absence and will draw at least one more start for the Browns. Head coach Kevin Stefanski said he won't name a starter past this week, so Gabriel could take over again if Sanders struggles.

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Baltimore Ravens wide receiver Rashod Bateman (ankle) was listed as a limited participant during Monday's estimated practice. Bateman didn't practice at all last week and sat out Sunday's game against the New York Jets. Now, Bateman appears to be in danger of missing his third straight game due to this lingering ankle injury. He'll get two more chances to practice ahead of Thursday's Thanksgiving matchup against the Cincinnati Bengals. If he remains out, Zay Flowers, DeAndre Hopkins, and Tylan Wallace would continue to see more chances.

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Detroit Lions tight end Brock Wright (neck) was listed as a non-participant during Monday's estimated practice. Wright played nearly 90 percent of the offensive snaps on Sunday, but appears to have picked up a neck injury along the way. His status is now uncertain heading into a short week with a matchup against the Green Bay Packers on Thanksgiving. The Lions are already without Sam LaPorta (back), so losing Wright would really put them in a bad spot. The 26-year-old hauled in three of his four targets for 29 yards during Sunday's win over the New York Giants. Fantasy managers will need to check back for another update on his status.

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Arizona Cardinals head coach Jonathan Gannon did not give an update on wide receiver Marvin Harrison Jr.'s (appendix) status for Week 13 on Monday, according to Theo Mackie of The Arizona Republic. "When he's physically and mentally healthy to play, he'll play," Gannon said. Harrison has missed the last two games after undergoing an appendectomy. In the 23-year-old's absence, Michael Wilson has suddenly turned into Ja'Marr Chase, catching 25 of his 33 targets for 303 receiving yards. Greg Dortch has also seen a big uptick in production, catching 12 of his 15 targets for 119 yards and two touchdowns. As of right now, it seems as though Harrison will be in line to miss a third straight game this Sunday against the Tampa Bay Buccaneers. If Harrison is out again, Wilson will be a must-start in all fantasy formats because of his major role upgrade.

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The Arizona Cardinals could tweak their offense to make wide receiver Michael Wilson the WR1, even when Marvin Harrison Jr. (appendix) returns, according to Theo Mackie of The Arizona Republic. "Yeah. Throw it to the guys that are making plays for you. Absolutely," head coach Jonathan Gannon said when asked if Wilson could stay more involved when Harrison is back. In the two games that Harrison has missed due to an appendectomy, Wilson has gone off, catching 25 of 33 targets for 303 receiving yards. The sudden uptick in workload has made him a must-roster and must-start player in fantasy football as quarterback Jacoby Brissett continues to latch onto him as his top target. Wilson's target share will inevitably drop when Harrison returns, but it might not end up being all that big of a drop. Even if Harrison returns in Week 13 against the Tampa Bay Buccaneers, Wilson should at least be in play as a WR3/flex for fantasy managers.

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Arizona Cardinals quarterback Kyler Murray (foot) is eligible to come off Injured Reserve in Week 14 against the division-rival Los Angeles Rams, according to Theo Mackie of The Arizona Republic. "He's working hard to get healthy. That's what he's doing right now. He's in every meeting, and he's engaged. He's rehabbing a boatload of time in there," head coach Jonathan Gannon said on Monday. Murray has been sidelined since suffering a mid-foot sprain in the Week 5 loss to the Tennessee Titans. It was reported earlier this month that Murray will be the backup QB when he's ready to come off IR, as veteran Jacoby Brissett has given the Cardinals' passing offense a spark since Murray went down with an injury. Another disappointing and injury-plagued season for Murray has put his long-term future in doubt in Arizona.

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Dallas Cowboys wide receiver George Pickens (calf, knee) was listed as a limited participant on Monday on the team's estimated injury report, according to The Athletic's Jon Machota. According to head coach Brian Schottenheimer, Pickens is dealing with a sore shin after Sunday's comeback victory over the Philadelphia Eagles. The 24-year-old is also listed with calf and knee injuries, so fantasy managers will want to keep a close eye on his status going into Thursday's matchup against the Kansas City Chiefs on Thanksgiving Day. The expectation is that Pickens will be ready to roll in Week 13, where he should once again be heavily targeted in the passing game. Pickens leads Dallas in catches (67), targets (92), receiving yards (1,054), and touchdowns (eight) in his first year with the team. If active on Thursday, Pickens is a must-start in fantasy despite the tough matchup.

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