

| Benched | WR | Keon Coleman BUF | Owner | Tue Nov 25 4:14pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 4:14pm ET |
| Benched | WR | Marquise Brown KC | Owner | Tue Nov 25 4:14pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 4:14pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 8:11am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:11am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 8:55am ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 8:55am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 25 8:55am ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 8:55am ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 8:55am ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 8:55am ET |
| Benched | WR | Tetairoa McMillan CAR | Owner | Tue Nov 25 11:10am ET |
| Started | RB | Emanuel Wilson GB | Owner | Tue Nov 25 11:10am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 7:49am ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Tue Nov 25 7:49am ET |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 25 7:49am ET |
| Started | D/ST | New England Patriots NE | Owner | Tue Nov 25 7:49am ET |