

| Benched | QB | Sam Darnold SEA | Owner | Tue Nov 25 5:59pm CT |
| Started | QB | Baker Mayfield TB | Owner | Tue Nov 25 5:59pm CT |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 5:58pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 5:58pm CT |
| Benched | WR | Keon Coleman BUF | Owner | Tue Nov 25 3:14pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 3:14pm CT |
| Benched | WR | Marquise Brown KC | Owner | Tue Nov 25 3:14pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 3:14pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 7:11am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 7:11am CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 5:25pm CT |
| Started | QB | Dak Prescott DAL | Owner | Tue Nov 25 5:25pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 5:24pm CT |
| Started | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 5:24pm CT |
| Benched | K | Joshua Karty LAR | Owner | Thu Nov 27 11:09am CT |
| Benched | D/ST | Dallas Cowboys DAL | Owner | Thu Nov 27 11:09am CT |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 11:09am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 11:09am CT |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 7:55am CT |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 7:55am CT |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 25 7:55am CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 7:55am CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 7:55am CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 7:55am CT |
| Benched | WR | Tetairoa McMillan CAR | Owner | Thu Nov 27 6:14am CT |
| Started | WR | Michael Wilson ARI | Owner | Thu Nov 27 6:14am CT |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 8:59pm CT |
| Started | WR | Tetairoa McMillan CAR | Owner | Wed Nov 26 8:59pm CT |
| Benched | WR | Tetairoa McMillan CAR | Owner | Tue Nov 25 10:10am CT |
| Started | RB | Emanuel Wilson GB | Owner | Tue Nov 25 10:10am CT |
| Benched | WR | Drake London ATL | Owner | Thu Nov 27 8:42am CT |
| Started | WR | Marvin Mims DEN | Owner | Thu Nov 27 8:42am CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 8:26pm CT |
| Started | WR | Cooper Kupp SEA | Owner | Tue Nov 25 8:26pm CT |
| Benched | RB | Jordan Mason MIN | Owner | Tue Nov 25 8:26pm CT |
| Benched | K | Matt Prater BUF | Owner | Tue Nov 25 8:26pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 8:26pm CT |
| Started | K | Harrison Butker KC | Owner | Tue Nov 25 8:26pm CT |
| No starting lineup changes performed this week. |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 12:17am CT |
| Benched | D/ST | New England Patriots NE | Owner | Thu Nov 27 12:17am CT |
| Started | RB | Woody Marks HOU | Owner | Wed Nov 26 9:13pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 9:13pm CT |
| Benched | WR | Jameson Williams DET | Owner | Wed Nov 26 9:13pm CT |
| Benched | WR | Stefon Diggs NE | Owner | Wed Nov 26 9:13pm CT |
| Started | D/ST | New England Patriots NE | Owner | Tue Nov 25 6:49am CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 25 6:49am CT |
| Benched | D/ST | Cleveland Browns CLE | Owner | Tue Nov 25 6:49am CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 6:49am CT |