

| Benched | QB | Jordan Love GB | Owner | Tue Nov 4 8:01am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 8:01am ET |
| Benched | K | Detroit Lions DET | Owner | Tue Nov 4 8:01am ET |
| Started | QB | Caleb Williams CHI | Owner | Tue Nov 4 8:01am ET |
| Started | WR | Tetairoa McMillan CAR | Owner | Tue Nov 4 8:01am ET |
| Started | K | Tampa Bay Buccaneers TB | Owner | Tue Nov 4 8:01am ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Tue Nov 4 11:46am ET |
| Benched | RB | TreVeyon Henderson NE | Owner | Tue Nov 4 11:46am ET |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 4 11:46am ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 11:46am ET |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 11:46am ET |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 11:46am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Keaton Mitchell BAL | Owner | Tue Nov 4 11:56pm ET |
| Started | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 4 11:56pm ET |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 11:31am ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 4 11:31am ET |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 4 10:59am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 4 10:59am ET |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 4 10:59am ET |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 10:59am ET |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 10:59am ET |
| Started | RB | Rachaad White TB | Owner | Tue Nov 4 10:59am ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 4 4:05pm ET |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 4 4:05pm ET |
| Benched | WR | Troy Franklin DEN | Owner | Tue Nov 4 4:05pm ET |
| Benched | RB | RJ Harvey DEN | Owner | Tue Nov 4 4:05pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 2:28pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 4 2:28pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 4 2:28pm ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 4 2:28pm ET |
| Benched | RB | Jaylen Warren PIT | Owner | Tue Nov 4 2:28pm ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 4 2:28pm ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 3:45pm ET |
| Started | WR | Zay Flowers BAL | Owner | Tue Nov 4 3:45pm ET |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 7:35pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 7:35pm ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 7:35pm ET |
| Started | QB | Matthew Stafford LAR | Owner | Tue Nov 4 7:35pm ET |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Nov 4 7:35pm ET |
| Started | WR | Jameson Williams DET | Owner | Tue Nov 4 7:35pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Malik Washington MIA | Owner | Tue Nov 4 8:23am ET |
| Started | WR | Rashid Shaheed SEA | Owner | Tue Nov 4 8:23am ET |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 8:23am ET |
| Benched | TE | Tucker Kraft GB | Owner | Tue Nov 4 8:23am ET |
| Started | RB | Rhamondre Stevenson NE | Owner | Tue Nov 4 8:23am ET |
| Started | WR | Tory Horton SEA | Owner | Tue Nov 4 8:23am ET |
| Benched | D/ST | Detroit Lions DET | Owner | Tue Nov 4 10:25am ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 4 10:25am ET |
| No starting lineup changes performed this week. |