

| Drop TB | QB | Brock Purdy SF | Owner | Thu Dec 18 6:03pm ET |
| Benched | WR | Tre Tucker LV | Owner | Thu Dec 18 6:03pm ET |
| Add TB | QB | Jalen Milroe SEA | Owner | Thu Dec 18 6:03pm ET |
| Started | TE | Cade Otton TB | Owner | Thu Dec 18 6:03pm ET |
| Benched | RB | Jaleel McLaughlin DEN | Owner | Tue Dec 16 7:51pm ET |
| Benched | DB | Jaylon Carlies IND | Owner | Tue Dec 16 7:51pm ET |
| Started | RB | Keaton Mitchell BAL | Owner | Tue Dec 16 7:51pm ET |
| Started | DB | Chuck Clark PIT | Owner | Tue Dec 16 7:51pm ET |
| No starting lineup changes performed this week. |
| Drop TB | QB | Matthew Stafford LAR | Owner | Thu Dec 18 3:21pm ET |
| Add TB | WR | Jaxon Smith-Njigba SEA | Owner | Thu Dec 18 3:21pm ET |
| Started | WR | Drake London ATL | Owner | Thu Dec 18 3:20pm ET |
| Add TB | QB | Matthew Stafford LAR | Owner | Thu Dec 18 3:20pm ET |
| Drop TB | WR | Jaxon Smith-Njigba SEA | Owner | Thu Dec 18 3:20pm ET |
| Benched | RB | Rico Dowdle CAR | Owner | Thu Dec 18 3:20pm ET |
| Started | WR | George Pickens DAL | Owner | Thu Dec 18 12:53pm ET |
| Benched | WR | Luther Burden III CHI | Owner | Thu Dec 18 12:53pm ET |
| Started | LB | Akeem Davis-Gaither ARI | Owner | Tue Dec 16 8:04am ET |
| Started | WR | Luther Burden III CHI | Owner | Tue Dec 16 8:04am ET |
| Started | QB | C.J. Stroud HOU | Owner | Tue Dec 16 8:04am ET |
| Benched | LB | Owen Pappoe ARI | Owner | Tue Dec 16 8:04am ET |
| Benched | WR | George Pickens DAL | Owner | Tue Dec 16 8:04am ET |
| Benched | QB | Matthew Stafford LAR | Owner | Tue Dec 16 8:04am ET |
| Benched | WR | Zay Flowers BAL | Owner | Tue Dec 16 8:47am ET |
| Benched | WR | Tetairoa McMillan CAR | Owner | Tue Dec 16 8:47am ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Dec 16 8:47am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Dec 16 8:47am ET |
| Benched | QB | Patrick Mahomes KC | Owner | Thu Dec 18 4:44pm ET |
| Benched | LB | Barrett Carter CIN | Owner | Thu Dec 18 4:44pm ET |
| Started | QB | Jacoby Brissett ARI | Owner | Thu Dec 18 4:44pm ET |
| Started | LB | T.J. Edwards CHI | Owner | Thu Dec 18 4:44pm ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Thu Dec 18 9:54am ET |
| Started | WR | Tee Higgins CIN | Owner | Thu Dec 18 9:54am ET |
| Benched | RB | Rachaad White TB | Owner | Tue Dec 16 9:28pm ET |
| Started | TE | Pat Freiermuth PIT | Owner | Tue Dec 16 9:28pm ET |
| Benched | WR | Davante Adams LAR | Owner | Thu Dec 18 7:10pm ET |
| Started | RB | Woody Marks HOU | Owner | Thu Dec 18 7:10pm ET |
| Benched | DB | Kevin Winston Jr. TEN | Owner | Tue Dec 16 10:24pm ET |
| Started | DB | Josh Metellus MIN | Owner | Tue Dec 16 10:24pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | WR | Rashee Rice KC | Owner | Wed Dec 17 11:20pm ET |
| Started | TE | Gunnar Helm TEN | Owner | Wed Dec 17 11:20pm ET |
| Benched | DB | DaRon Bland DAL | Owner | Wed Dec 17 11:18pm ET |
| Benched | DB | Reed Blankenship PHI | Owner | Wed Dec 17 11:18pm ET |
| Started | DB | Derwin James LAC | Owner | Wed Dec 17 11:18pm ET |
| Started | DB | Jalen Ramsey PIT | Owner | Wed Dec 17 11:18pm ET |
| Benched | TE | Anthony Firkser DET | Owner | Tue Dec 16 11:29pm ET |
| Started | TE | Theo Johnson NYG | Owner | Tue Dec 16 11:29pm ET |
| Benched | QB | Shedeur Sanders CLE | Owner | Tue Dec 16 11:27pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Dec 16 11:27pm ET |