

| Benched | RB | Jaleel McLaughlin DEN | Owner | Tue Dec 16 7:51pm ET |
| Benched | DB | Jaylon Carlies IND | Owner | Tue Dec 16 7:51pm ET |
| Started | RB | Keaton Mitchell BAL | Owner | Tue Dec 16 7:51pm ET |
| Started | DB | Chuck Clark PIT | Owner | Tue Dec 16 7:51pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Matthew Stafford LAR | Owner | Tue Dec 16 8:04am ET |
| Benched | WR | George Pickens DAL | Owner | Tue Dec 16 8:04am ET |
| Benched | LB | Owen Pappoe ARI | Owner | Tue Dec 16 8:04am ET |
| Started | QB | C.J. Stroud HOU | Owner | Tue Dec 16 8:04am ET |
| Started | WR | Luther Burden III CHI | Owner | Tue Dec 16 8:04am ET |
| Started | LB | Akeem Davis-Gaither ARI | Owner | Tue Dec 16 8:04am ET |
| Benched | WR | Zay Flowers BAL | Owner | Tue Dec 16 8:47am ET |
| Benched | WR | Tetairoa McMillan CAR | Owner | Tue Dec 16 8:47am ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Dec 16 8:47am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Dec 16 8:47am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Rachaad White TB | Owner | Tue Dec 16 9:28pm ET |
| Started | TE | Pat Freiermuth PIT | Owner | Tue Dec 16 9:28pm ET |
| No starting lineup changes performed this week. |
| Benched | DB | Kevin Winston Jr. TEN | Owner | Tue Dec 16 10:24pm ET |
| Started | DB | Josh Metellus MIN | Owner | Tue Dec 16 10:24pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | TE | Anthony Firkser DET | Owner | Tue Dec 16 11:29pm ET |
| Started | TE | Theo Johnson NYG | Owner | Tue Dec 16 11:29pm ET |
| Benched | QB | Shedeur Sanders CLE | Owner | Tue Dec 16 11:27pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Dec 16 11:27pm ET |