

| Benched | QB | Joe Flacco CIN | Owner | Wed Nov 26 8:52pm CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 8:52pm CT |
| Benched | TE | T.J. Hockenson MIN | Owner | Thu Nov 27 9:13am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 9:13am CT |
| Benched | D/ST | Houston Texans HOU | Owner | Thu Nov 27 9:07am CT |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 27 9:07am CT |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Thu Nov 27 11:28am CT |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 11:28am CT |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 7:13pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:13pm CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 7:13pm CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 7:13pm CT |
| No starting lineup changes performed this week. |
| Benched | TE | Tyler Warren IND | Owner | Thu Nov 27 11:34am CT |
| Started | RB | Kareem Hunt KC | Owner | Thu Nov 27 11:34am CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 8:46am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:46am CT |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 10:31am CT |
| Started | WR | Chris Olave NO | Owner | Thu Nov 27 10:31am CT |
| Benched | QB | Caleb Williams CHI | Owner | Thu Nov 27 11:30am CT |
| Benched | WR | Jauan Jennings SF | Owner | Thu Nov 27 11:30am CT |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 11:30am CT |
| Started | WR | Troy Franklin DEN | Owner | Thu Nov 27 11:30am CT |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 9:38pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 9:38pm CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Wed Nov 26 9:22pm CT |
| Benched | K | Cairo Santos CHI | Owner | Wed Nov 26 9:22pm CT |
| Started | RB | Kenneth Walker III SEA | Owner | Wed Nov 26 9:22pm CT |
| Started | K | Wil Lutz DEN | Owner | Wed Nov 26 9:22pm CT |
| Benched | RB | Kenneth Walker III SEA | Owner | Tue Nov 25 7:27pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 7:27pm CT |