

| Benched | WR | Drake London ATL | Owner | Thu Nov 27 12:09pm ET |
| Started | TE | Colston Loveland CHI | Owner | Thu Nov 27 12:09pm ET |
| Benched | D/ST | Chicago Bears CHI | Owner | Tue Nov 25 1:22pm ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 25 1:22pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 1:22pm ET |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 1:22pm ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 12:26pm ET |
| Benched | RB | Aaron Jones MIN | Owner | Thu Nov 27 12:26pm ET |
| Started | RB | Aaron Jones MIN | Owner | Wed Nov 26 1:18am ET |
| Benched | RB | Devin Neal NO | Owner | Wed Nov 26 1:18am ET |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 1:18am ET |
| Benched | RB | Aaron Jones MIN | Owner | Wed Nov 26 1:18am ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 10:38pm ET |
| Started | WR | Michael Wilson ARI | Owner | Tue Nov 25 10:38pm ET |
| Benched | K | Tyler Loop BAL | Owner | Tue Nov 25 10:38pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 10:38pm ET |
| Started | D/ST | Atlanta Falcons ATL | Owner | Wed Nov 26 12:29am ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 11:26pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 11:26pm ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 1:34pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 1:34pm ET |
| Benched | RB | Trey Benson ARI | Owner | Wed Nov 26 11:27pm ET |
| Started | WR | Kayshon Boutte NE | Owner | Wed Nov 26 11:27pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 9:08am ET |
| Started | RB | Trey Benson ARI | Owner | Tue Nov 25 9:08am ET |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 9:05am ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 9:05am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 9:25pm ET |
| Started | WR | Emeka Egbuka TB | Owner | Wed Nov 26 9:25pm ET |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 25 2:29pm ET |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Nov 25 2:29pm ET |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 2:29pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 2:29pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 2:29pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 2:29pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 1:32pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Thu Nov 27 1:32pm ET |
| Benched | D/ST | Buffalo Bills BUF | Owner | Wed Nov 26 8:18am ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Wed Nov 26 8:18am ET |
| Benched | RB | Josh Jacobs GB | Owner | Wed Nov 26 8:18am ET |
| Started | RB | Rachaad White TB | Owner | Wed Nov 26 8:18am ET |
| Benched | RB | Omarion Hampton LAC | Owner | Sat Nov 29 5:02pm ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Sat Nov 29 5:02pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 9:45am ET |
| Started | RB | Omarion Hampton LAC | Owner | Thu Nov 27 9:45am ET |
| Started | D/ST | Miami Dolphins MIA | Owner | Thu Nov 27 9:43am ET |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 10:48pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 10:48pm ET |
| Benched | WR | Mack Hollins NE | Owner | Wed Nov 26 12:32am ET |
| Benched | TE | AJ Barner SEA | Owner | Wed Nov 26 12:32am ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 12:32am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 12:32am ET |
| Started | K | Andres Borregales NE | Owner | Fri Nov 28 5:38pm ET |
| Started | K | Will Reichard MIN | Owner | Wed Nov 26 8:20pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 1:45pm ET |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Nov 25 1:45pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 1:45pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 1:45pm ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Thu Nov 27 11:49am ET |
| Started | WR | Christian Watson GB | Owner | Thu Nov 27 11:49am ET |
| Benched | WR | Christian Watson GB | Owner | Wed Nov 26 4:26pm ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 4:26pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Wed Nov 26 6:27am ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 6:27am ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 6:27am ET |
| Started | TE | Brenton Strange JAX | Owner | Wed Nov 26 6:27am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Marquise Brown KC | Owner | Tue Nov 25 8:39pm ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 8:39pm ET |