

| Benched | QB | Patrick Mahomes KC | Commissioner | Fri Dec 12 4:41pm ET |
| Benched | D/ST | Minnesota Vikings MIN | Commissioner | Fri Dec 12 4:41pm ET |
| Started | QB | Brock Purdy SF | Commissioner | Fri Dec 12 4:41pm ET |
| Started | D/ST | New Orleans Saints NO | Commissioner | Fri Dec 12 4:41pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Sun Dec 14 12:07pm ET |
| Started | RB | David Montgomery DET | Owner | Sun Dec 14 12:07pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Jordan Addison MIN | Owner | Sun Dec 14 6:07am ET |
| Benched | WR | Alec Pierce IND | Owner | Sun Dec 14 6:07am ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Sun Dec 14 6:07am ET |
| Started | RB | Christian McCaffrey SF | Owner | Sun Dec 14 6:07am ET |
| Started | WR | Tetairoa McMillan CAR | Owner | Sun Dec 14 6:07am ET |
| Started | TE | Darren Waller MIA | Owner | Sun Dec 14 6:07am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Caleb Williams CHI | Owner | Wed Dec 10 10:56am ET |
| Benched | WR | D.J. Moore CHI | Owner | Wed Dec 10 10:56am ET |
| Benched | D/ST | Atlanta Falcons ATL | Owner | Wed Dec 10 10:56am ET |
| Started | QB | Drake Maye NE | Owner | Wed Dec 10 10:56am ET |
| Started | RB | Jaylen Warren PIT | Owner | Wed Dec 10 10:56am ET |
| Started | D/ST | Chicago Bears CHI | Owner | Wed Dec 10 10:56am ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Sun Dec 14 9:15am ET |
| Benched | D/ST | San Francisco 49ers SF | Owner | Sun Dec 14 9:15am ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Wed Dec 10 2:32pm ET |
| Benched | WR | Jayden Reed GB | Owner | Wed Dec 10 2:32pm ET |
| Started | D/ST | San Francisco 49ers SF | Owner | Wed Dec 10 2:30pm ET |
| Started | TE | George Kittle SF | Owner | Wed Dec 10 2:30pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Dec 10 2:30pm ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Wed Dec 10 2:30pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Wed Dec 10 2:30pm ET |
| Benched | QB | Jordan Love GB | Owner | Wed Dec 10 2:30pm ET |
| Benched | QB | Sam Darnold SEA | Owner | Tue Dec 9 10:34pm ET |
| Started | QB | C.J. Stroud HOU | Owner | Tue Dec 9 10:34pm ET |
| Benched | TE | T.J. Hockenson MIN | Owner | Tue Dec 9 9:44am ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Tue Dec 9 9:44am ET |
| Started | WR | Jauan Jennings SF | Owner | Tue Dec 9 9:44am ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Tue Dec 9 9:44am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |