

| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 4:44pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 4:44pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 4 4:44pm ET |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 4:44pm ET |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Nov 4 4:44pm ET |
| Started | TE | Jake Ferguson DAL | Owner | Tue Nov 4 4:44pm ET |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 7:09am ET |
| Benched | TE | AJ Barner SEA | Owner | Tue Nov 4 7:09am ET |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 7:09am ET |
| Benched | WR | Darius Slayton NYG | Owner | Tue Nov 4 7:09am ET |
| Started | RB | Dylan Sampson CLE | Owner | Tue Nov 4 7:09am ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 7:09am ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 4 7:08am ET |
| Started | K | Cairo Santos CHI | Owner | Tue Nov 4 7:08am ET |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 4 7:08am ET |
| Benched | K | Brandon Aubrey DAL | Owner | Tue Nov 4 7:08am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 4 11:05am ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 11:05am ET |
| Started | RB | Chuba Hubbard CAR | Owner | Tue Nov 4 11:05am ET |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 11:05am ET |
| Benched | K | Tyler Loop BAL | Owner | Tue Nov 4 2:38pm ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Tue Nov 4 2:38pm ET |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 4 12:30pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 4 12:30pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Travis Etienne JAX | Owner | Wed Nov 5 8:22am ET |
| Benched | TE | Tucker Kraft GB | Owner | Wed Nov 5 8:22am ET |
| Started | RB | Saquon Barkley PHI | Owner | Wed Nov 5 8:22am ET |
| Started | WR | Sterling Shepard TB | Owner | Wed Nov 5 8:22am ET |
| Started | RB | Kyle Monangai CHI | Owner | Tue Nov 4 8:52am ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 4 8:52am ET |
| Started | HC | Nick Sirianni PHI | Owner | Tue Nov 4 8:51am ET |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 8:51am ET |
| Started | WR | Jordan Addison MIN | Owner | Tue Nov 4 8:51am ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 8:51am ET |
| Benched | HC | Ben Johnson CHI | Owner | Tue Nov 4 8:51am ET |
| Benched | WR | Khalil Shakir BUF | Owner | Tue Nov 4 8:51am ET |
| Benched | WR | Zay Flowers BAL | Owner | Tue Nov 4 8:51am ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 4 8:51am ET |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 4 7:03am ET |
| Benched | D/ST | Washington Commanders WAS | Owner | Tue Nov 4 7:03am ET |
| Benched | HC | Mike Tomlin PIT | Owner | Tue Nov 4 7:03am ET |
| Started | WR | Davante Adams LAR | Owner | Tue Nov 4 7:03am ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Tue Nov 4 7:03am ET |
| Started | HC | Kevin Stefanski CLE | Owner | Tue Nov 4 7:03am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 8:34am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 8:34am ET |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Nov 4 8:34am ET |
| Started | TE | Brock Bowers LV | Owner | Tue Nov 4 8:34am ET |
| Benched | QB | Tua Tagovailoa MIA | Owner | Tue Nov 4 7:15am ET |
| Started | K | Chase McLaughlin TB | Owner | Tue Nov 4 7:15am ET |
| Started | WR | Tez Johnson TB | Owner | Tue Nov 4 7:15am ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 4 7:15am ET |
| Started | QB | Michael Penix Jr. ATL | Owner | Tue Nov 4 7:15am ET |
| Benched | D/ST | Atlanta Falcons ATL | Owner | Tue Nov 4 7:15am ET |
| Benched | K | Andres Borregales NE | Owner | Tue Nov 4 7:15am ET |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 7:15am ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 4 7:15am ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Tue Nov 4 7:15am ET |
| No starting lineup changes performed this week. |