

| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Sat Nov 8 4:40am ET |
| Started | TE | Cade Otton TB | Owner | Sat Nov 8 4:40am ET |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 11:15am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 4 11:15am ET |
| Started | QB | Michael Penix Jr. ATL | Owner | Tue Nov 4 11:15am ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Tue Nov 4 11:15am ET |
| Benched | WR | Mack Hollins NE | Owner | Thu Nov 6 3:23am ET |
| Started | WR | Demario Douglas NE | Owner | Thu Nov 6 3:23am ET |
| Benched | QB | Justin Herbert LAC | Owner | Tue Nov 4 11:03pm ET |
| Started | QB | Jared Goff DET | Owner | Tue Nov 4 11:03pm ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 11:01pm ET |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 11:01pm ET |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 11:01pm ET |
| Started | TE | Jonnu Smith PIT | Owner | Tue Nov 4 11:01pm ET |
| Started | K | Andres Borregales NE | Owner | Tue Nov 4 11:01pm ET |
| Benched | TE | Kyle Pitts ATL | Owner | Thu Nov 6 12:41pm ET |
| Started | RB | TreVeyon Henderson NE | Owner | Thu Nov 6 12:41pm ET |
| Benched | RB | Chase Brown CIN | Owner | Wed Nov 5 4:57pm ET |
| Benched | RB | TreVeyon Henderson NE | Owner | Wed Nov 5 4:57pm ET |
| Benched | WR | Josh Downs IND | Owner | Wed Nov 5 4:57pm ET |
| Started | RB | Quinshon Judkins CLE | Owner | Wed Nov 5 4:57pm ET |
| Started | WR | Alec Pierce IND | Owner | Wed Nov 5 4:57pm ET |
| Started | TE | Kyle Pitts ATL | Owner | Wed Nov 5 4:57pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Sat Nov 8 12:23am ET |
| Started | WR | Malik Washington MIA | Owner | Sat Nov 8 12:23am ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Thu Nov 6 1:53pm ET |
| Started | QB | Baker Mayfield TB | Owner | Thu Nov 6 1:53pm ET |
| Benched | TE | AJ Barner SEA | Owner | Thu Nov 6 1:48pm ET |
| Started | TE | Dalton Kincaid BUF | Owner | Thu Nov 6 1:48pm ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 4 2:48pm ET |
| Started | RB | Nick Chubb HOU | Owner | Tue Nov 4 2:48pm ET |
| Benched | WR | Keon Coleman BUF | Owner | Wed Nov 5 12:30am ET |
| Started | RB | Chuba Hubbard CAR | Owner | Wed Nov 5 12:30am ET |
| Benched | TE | Zach Ertz WAS | Owner | Tue Nov 4 10:04am ET |
| Started | WR | Keon Coleman BUF | Owner | Tue Nov 4 10:04am ET |
| Benched | RB | Samaje Perine CIN | Owner | Tue Nov 4 10:03am ET |
| Started | TE | Hunter Henry NE | Owner | Tue Nov 4 10:03am ET |
| Started | K | Will Reichard MIN | Owner | Thu Nov 6 12:14am ET |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 4 9:54pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 9:54pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 12:00pm ET |
| Benched | WR | Calvin Austin III PIT | Owner | Tue Nov 4 12:00pm ET |
| Started | RB | Isaiah Davis NYJ | Owner | Tue Nov 4 12:00pm ET |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 12:00pm ET |
| Started | RB | Zach Charbonnet SEA | Owner | Thu Nov 6 11:31am ET |
| Started | QB | Justin Fields NYJ | Owner | Thu Nov 6 11:31am ET |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 6 11:31am ET |
| Benched | QB | Brock Purdy SF | Owner | Thu Nov 6 11:31am ET |
| Started | WR | Jerry Jeudy CLE | Owner | Thu Nov 6 11:27am ET |
| Benched | WR | Ricky Pearsall SF | Owner | Thu Nov 6 11:27am ET |
| Started | D/ST | Indianapolis Colts IND | Owner | Thu Nov 6 11:26am ET |
| Started | TE | Colston Loveland CHI | Owner | Thu Nov 6 11:26am ET |
| Started | K | Chase McLaughlin TB | Owner | Tue Nov 4 11:32am ET |
| Started | WR | Ricky Pearsall SF | Owner | Tue Nov 4 11:32am ET |
| Started | QB | Brock Purdy SF | Owner | Tue Nov 4 11:32am ET |
| Benched | D/ST | Green Bay Packers GB | Owner | Tue Nov 4 11:32am ET |
| Benched | K | Matt Prater BUF | Owner | Tue Nov 4 11:32am ET |
| Benched | TE | Tucker Kraft GB | Owner | Tue Nov 4 11:32am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 11:32am ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 4 11:32am ET |
| Started | WR | Olamide Zaccheaus CHI | Owner | Thu Nov 6 12:12am ET |
| Benched | WR | Rashod Bateman BAL | Owner | Thu Nov 6 12:12am ET |
| Started | K | Eddy Pineiro SF | Owner | Thu Nov 6 12:12am ET |
| Started | WR | Rashod Bateman BAL | Owner | Thu Nov 6 12:12am ET |
| Benched | WR | Matthew Golden GB | Owner | Thu Nov 6 12:12am ET |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 12:40pm ET |
| Started | WR | Matthew Golden GB | Owner | Tue Nov 4 12:40pm ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Nov 4 12:40pm ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 12:40pm ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 12:40pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 4 12:40pm ET |
| Started | D/ST | Carolina Panthers CAR | Owner | Thu Nov 6 4:24am ET |
| Benched | RB | RJ Harvey DEN | Owner | Tue Nov 4 4:31pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 4 4:31pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Jordan Mason MIN | Owner | Wed Nov 5 9:52am ET |
| Started | RB | Rachaad White TB | Owner | Wed Nov 5 9:52am ET |
| Benched | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 5 12:54am ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Wed Nov 5 12:54am ET |
| Benched | WR | George Pickens DAL | Owner | Wed Nov 5 12:54am ET |
| Started | RB | Jordan Mason MIN | Owner | Wed Nov 5 12:54am ET |
| Benched | WR | Zay Flowers BAL | Owner | Tue Nov 4 6:34pm ET |
| Started | WR | Rashid Shaheed SEA | Owner | Tue Nov 4 6:34pm ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 4 6:32pm ET |
| Started | WR | Jakobi Meyers JAX | Owner | Tue Nov 4 6:32pm ET |
| Benched | QB | Trevor Lawrence JAX | Owner | Tue Nov 4 10:13am ET |
| Benched | RB | Blake Corum LAR | Owner | Tue Nov 4 10:13am ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 10:13am ET |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 10:13am ET |