

| Benched | RB | Devon Achane MIA | Owner | Tue Nov 18 11:07am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 18 11:07am ET |
| Benched | RB | Jaleel McLaughlin DEN | Owner | Tue Nov 18 11:07am ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 18 11:07am ET |
| Started | RB | Brashard Smith KC | Owner | Tue Nov 18 11:07am ET |
| Started | TE | Cade Otton TB | Owner | Tue Nov 18 11:07am ET |
| Started | D/ST | Detroit Lions DET | Owner | Thu Nov 20 12:05am ET |
| Benched | QB | Justin Herbert LAC | Owner | Tue Nov 18 9:03pm ET |
| Benched | WR | Marvin Mims DEN | Owner | Tue Nov 18 9:03pm ET |
| Started | QB | Jared Goff DET | Owner | Tue Nov 18 9:03pm ET |
| Started | WR | Chris Olave NO | Owner | Tue Nov 18 9:03pm ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Thu Nov 20 1:44pm ET |
| Benched | WR | Christian Watson GB | Owner | Thu Nov 20 1:44pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Thu Nov 20 1:44pm ET |
| Started | WR | Alec Pierce IND | Owner | Thu Nov 20 1:44pm ET |
| Started | TE | Tyler Warren IND | Owner | Thu Nov 20 1:44pm ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Thu Nov 20 1:44pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 18 8:51pm ET |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 18 8:51pm ET |
| Started | RB | Tony Pollard TEN | Owner | Tue Nov 18 8:51pm ET |
| Started | TE | AJ Barner SEA | Owner | Tue Nov 18 8:51pm ET |
| Benched | RB | Chris Rodriguez Jr. WAS | Owner | Tue Nov 18 10:39pm ET |
| Benched | WR | Tyler Lockett LV | Owner | Tue Nov 18 10:39pm ET |
| Benched | D/ST | Atlanta Falcons ATL | Owner | Tue Nov 18 10:39pm ET |
| Started | RB | Jonathan Taylor IND | Owner | Tue Nov 18 10:39pm ET |
| Started | WR | Chimere Dike TEN | Owner | Tue Nov 18 10:39pm ET |
| Started | D/ST | Seattle Seahawks SEA | Owner | Tue Nov 18 10:39pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Jerry Jeudy CLE | Owner | Thu Nov 20 2:03am ET |
| Started | RB | Emanuel Wilson GB | Owner | Thu Nov 20 2:03am ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 18 8:57am ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 18 8:57am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 18 8:57am ET |
| Started | QB | Brock Purdy SF | Owner | Tue Nov 18 8:57am ET |
| Started | RB | Alvin Kamara NO | Owner | Tue Nov 18 8:57am ET |
| Started | WR | Jerry Jeudy CLE | Owner | Tue Nov 18 8:57am ET |
| Benched | WR | Elic Ayomanor TEN | Owner | Thu Nov 20 12:13am ET |
| Started | WR | Andrei Iosivas CIN | Owner | Thu Nov 20 12:13am ET |
| Started | K | Joey Slye TEN | Owner | Thu Nov 20 12:13am ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 18 12:29pm ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Tue Nov 18 12:29pm ET |
| Started | WR | Elic Ayomanor TEN | Owner | Tue Nov 18 12:29pm ET |
| Started | TE | Juwan Johnson NO | Owner | Tue Nov 18 12:29pm ET |
| Benched | RB | RJ Harvey DEN | Owner | Tue Nov 18 5:08pm ET |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Nov 18 5:08pm ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Tue Nov 18 5:08pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 18 5:08pm ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Nov 18 5:08pm ET |
| Started | WR | Michael Wilson ARI | Owner | Tue Nov 18 5:08pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |