

| No starting lineup changes performed this week. |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 4 11:47pm ET |
| Benched | RB | Nick Chubb HOU | Owner | Tue Nov 4 11:47pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 11:47pm ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 4 11:47pm ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 11:47pm ET |
| Started | RB | Aaron Jones MIN | Owner | Tue Nov 4 11:47pm ET |
| Started | WR | Keon Coleman BUF | Owner | Tue Nov 4 11:47pm ET |
| Started | WR | Chris Olave NO | Owner | Tue Nov 4 11:47pm ET |
| Benched | D/ST | Jacksonville Jaguars JAX | Owner | Wed Nov 5 6:06am ET |
| Started | D/ST | Minnesota Vikings MIN | Owner | Wed Nov 5 6:06am ET |
| Benched | WR | George Pickens DAL | Owner | Wed Nov 5 6:06am ET |
| Benched | K | Joey Slye TEN | Owner | Wed Nov 5 6:06am ET |
| Started | WR | Drake London ATL | Owner | Wed Nov 5 6:06am ET |
| Started | WR | Jerry Jeudy CLE | Owner | Fri Nov 7 8:07pm ET |
| Benched | WR | Tre Harris LAC | Owner | Fri Nov 7 8:07pm ET |
| Started | TE | Theo Johnson NYG | Owner | Thu Nov 6 7:06am ET |
| Benched | TE | Travis Kelce KC | Owner | Thu Nov 6 7:06am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 4 8:41am ET |
| Benched | D/ST | Los Angeles Chargers LAC | Owner | Tue Nov 4 8:41am ET |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 8:41am ET |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 8:41am ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 8:41am ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 8:41am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Wed Nov 5 9:01pm ET |
| Started | WR | Garrett Wilson NYJ | Owner | Wed Nov 5 9:01pm ET |
| Benched | QB | Kyler Murray ARI | Owner | Tue Nov 4 5:31pm ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 5:31pm ET |
| Started | QB | Justin Fields NYJ | Owner | Tue Nov 4 5:31pm ET |
| Started | WR | Davante Adams LAR | Owner | Tue Nov 4 5:31pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | WR | Khalil Shakir BUF | Owner | Tue Nov 4 12:35pm ET |
| Benched | TE | Tucker Kraft GB | Owner | Tue Nov 4 12:35pm ET |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 12:35pm ET |
| Started | TE | Evan Engram DEN | Owner | Tue Nov 4 12:35pm ET |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Thu Nov 6 10:51pm ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 6 10:51pm ET |
| Started | D/ST | Carolina Panthers CAR | Owner | Thu Nov 6 10:51pm ET |
| Benched | RB | TreVeyon Henderson NE | Owner | Thu Nov 6 8:27am ET |
| Started | QB | J.J. McCarthy MIN | Owner | Thu Nov 6 8:27am ET |
| Started | RB | Quinshon Judkins CLE | Owner | Thu Nov 6 8:27am ET |
| Started | WR | Tez Johnson TB | Owner | Thu Nov 6 8:27am ET |
| Benched | QB | Patrick Mahomes KC | Owner | Wed Nov 5 11:38pm ET |
| Benched | WR | Kayshon Boutte NE | Owner | Wed Nov 5 11:38pm ET |
| Benched | QB | Jayden Daniels WAS | Owner | Thu Nov 6 5:07am ET |
| Started | QB | Trevor Lawrence JAX | Owner | Thu Nov 6 5:07am ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 4 11:55pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 11:55pm ET |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 11:55pm ET |
| Started | TE | Mark Andrews BAL | Owner | Tue Nov 4 11:55pm ET |