

| No starting lineup changes performed this week. |
| Benched | TE | Evan Engram DEN | Owner | Thu Nov 6 4:53am ET |
| Started | WR | DeVonta Smith PHI | Owner | Thu Nov 6 4:53am ET |
| Benched | RB | Kyle Monangai CHI | Owner | Fri Nov 7 2:05pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Fri Nov 7 2:05pm ET |
| Started | RB | D'Andre Swift CHI | Owner | Fri Nov 7 2:05pm ET |
| Started | WR | Parker Washington JAX | Owner | Fri Nov 7 2:05pm ET |
| Benched | WR | George Pickens DAL | Owner | Wed Nov 5 12:42pm ET |
| Started | WR | Tee Higgins CIN | Owner | Wed Nov 5 12:42pm ET |
| Benched | QB | Patrick Mahomes KC | Owner | Wed Nov 5 6:27pm ET |
| Benched | RB | Chase Brown CIN | Owner | Wed Nov 5 6:27pm ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Wed Nov 5 6:27pm ET |
| Started | QB | Caleb Williams CHI | Owner | Wed Nov 5 6:27pm ET |
| Started | WR | Matthew Golden GB | Owner | Wed Nov 5 6:27pm ET |
| Benched | RB | Jordan Mason MIN | Owner | Fri Nov 7 9:01pm ET |
| Started | RB | Rachaad White TB | Owner | Fri Nov 7 9:01pm ET |
| Started | TE | Dalton Schultz HOU | Owner | Thu Nov 6 6:06pm ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Thu Nov 6 6:06pm ET |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 4 7:20pm ET |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 7:20pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 4 2:15pm ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 2:15pm ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Thu Nov 6 12:03am ET |
| Benched | RB | Zonovan Knight ARI | Owner | Thu Nov 6 12:03am ET |
| Started | RB | Saquon Barkley PHI | Owner | Thu Nov 6 12:03am ET |
| Started | WR | A.J. Brown PHI | Owner | Thu Nov 6 12:03am ET |
| Benched | K | Brandon Aubrey DAL | Owner | Thu Nov 6 6:58am ET |
| Started | K | Andres Borregales NE | Owner | Thu Nov 6 6:58am ET |
| Benched | QB | Jayden Daniels WAS | Owner | Tue Nov 4 7:42am ET |
| Started | QB | Aaron Rodgers PIT | Owner | Tue Nov 4 7:42am ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 7:42am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 4 7:42am ET |
| Started | D/ST | Carolina Panthers CAR | Owner | Thu Nov 6 7:59am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 6:02pm ET |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 4 6:02pm ET |
| Started | WR | Drake London ATL | Owner | Tue Nov 4 6:02pm ET |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 6:02pm ET |
| Benched | QB | Dak Prescott DAL | Owner | Thu Nov 6 6:12am ET |
| Started | QB | Jacoby Brissett ARI | Owner | Thu Nov 6 6:12am ET |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 4 8:49am ET |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 8:49am ET |
| Started | K | Jason Myers SEA | Owner | Thu Nov 6 6:30am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 4 10:04am ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 4 10:04am ET |
| Started | RB | Nick Chubb HOU | Owner | Tue Nov 4 10:04am ET |
| Started | WR | Kendrick Bourne SF | Owner | Tue Nov 4 10:04am ET |
| Benched | WR | Troy Franklin DEN | Owner | Wed Nov 5 3:19pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Wed Nov 5 3:19pm ET |
| Started | WR | Garrett Wilson NYJ | Owner | Wed Nov 5 3:19pm ET |
| Started | TE | Harold Fannin Jr. CLE | Owner | Wed Nov 5 3:19pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Wed Nov 5 11:24pm ET |
| Benched | WR | Kayshon Boutte NE | Owner | Wed Nov 5 11:24pm ET |
| Started | RB | Breece Hall NYJ | Owner | Wed Nov 5 11:24pm ET |
| Started | WR | Jauan Jennings SF | Owner | Wed Nov 5 11:24pm ET |