

| No starting lineup changes performed this week. |
| Started | K | Chad Ryland ARI | Owner | Thu Nov 6 4:58am ET |
| Benched | RB | Tony Pollard TEN | Owner | Tue Nov 4 9:41am ET |
| Benched | K | Harrison Butker KC | Owner | Tue Nov 4 9:41am ET |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 9:41am ET |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Wed Nov 5 8:29pm ET |
| Started | WR | Tre Tucker LV | Owner | Wed Nov 5 8:29pm ET |
| Started | D/ST | Carolina Panthers CAR | Owner | Thu Nov 6 6:50am ET |
| Benched | RB | TreVeyon Henderson NE | Owner | Tue Nov 4 6:38pm ET |
| Started | RB | Kyle Monangai CHI | Owner | Tue Nov 4 6:38pm ET |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 4 6:32pm ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 6:32pm ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 6:32pm ET |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 6:32pm ET |
| Started | RB | J.K. Dobbins DEN | Owner | Tue Nov 4 6:32pm ET |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 6:32pm ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 10:58am ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 10:58am ET |
| Started | WR | D.J. Moore CHI | Owner | Tue Nov 4 10:58am ET |
| Started | TE | Jonnu Smith PIT | Owner | Tue Nov 4 10:58am ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Wed Nov 5 11:52am ET |
| Started | RB | Breece Hall NYJ | Owner | Wed Nov 5 11:52am ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Wed Nov 5 11:52am ET |
| Started | WR | A.J. Brown PHI | Owner | Wed Nov 5 11:52am ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 5 11:52am ET |
| Started | QB | Justin Fields NYJ | Owner | Wed Nov 5 11:52am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Bucky Irving TB | Owner | Thu Nov 6 12:41am ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 6 12:41am ET |
| Benched | RB | Aaron Jones MIN | Owner | Wed Nov 5 4:55am ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 5 4:55am ET |
| Started | K | Chase McLaughlin TB | Owner | Thu Nov 6 6:31am ET |
| Started | D/ST | New England Patriots NE | Owner | Thu Nov 6 6:31am ET |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Wed Nov 5 9:30pm ET |
| Started | QB | Daniel Jones IND | Owner | Wed Nov 5 9:30pm ET |
| Started | RB | Woody Marks HOU | Owner | Wed Nov 5 9:30pm ET |
| Benched | RB | David Montgomery DET | Owner | Thu Nov 6 2:21pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Thu Nov 6 2:21pm ET |
| Benched | TE | Zach Ertz WAS | Owner | Thu Nov 6 2:21pm ET |
| Started | TE | Hunter Henry NE | Owner | Thu Nov 6 2:21pm ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Thu Nov 6 1:54am ET |
| Benched | RB | Kareem Hunt KC | Owner | Thu Nov 6 10:26am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Thu Nov 6 10:26am ET |
| Benched | WR | George Pickens DAL | Owner | Thu Nov 6 10:26am ET |
| Benched | TE | Travis Kelce KC | Owner | Thu Nov 6 10:26am ET |
| Started | RB | Ray Davis BUF | Owner | Thu Nov 6 10:26am ET |
| Started | WR | Troy Franklin DEN | Owner | Thu Nov 6 10:26am ET |
| Started | WR | Quentin Johnston LAC | Owner | Thu Nov 6 10:26am ET |
| Started | TE | Cade Otton TB | Owner | Thu Nov 6 10:26am ET |
| Benched | RB | Jeremy McNichols WAS | Owner | Thu Nov 6 4:15am ET |
| Started | RB | Emanuel Wilson GB | Owner | Thu Nov 6 4:15am ET |
| Started | TE | Dalton Kincaid BUF | Owner | Thu Nov 6 4:15am ET |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 8:28am ET |
| Benched | WR | Matthew Golden GB | Owner | Tue Nov 4 8:28am ET |
| Benched | TE | Tucker Kraft GB | Owner | Tue Nov 4 8:28am ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 8:28am ET |
| Started | RB | Jeremy McNichols WAS | Owner | Tue Nov 4 8:28am ET |