

| Benched | QB | Jared Goff DET | Owner | Thu Nov 6 7:38pm ET |
| Benched | RB | Tony Pollard TEN | Owner | Thu Nov 6 7:38pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 6 7:38pm ET |
| Started | QB | Jalen Hurts PHI | Owner | Thu Nov 6 7:38pm ET |
| Started | RB | Saquon Barkley PHI | Owner | Thu Nov 6 7:38pm ET |
| Started | WR | Jameson Williams DET | Owner | Thu Nov 6 7:38pm ET |
| Started | K | Andres Borregales NE | Owner | Thu Nov 6 7:38pm ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Thu Nov 6 7:38pm ET |
| Benched | QB | Matthew Stafford LAR | Owner | Tue Nov 4 5:28pm ET |
| Started | QB | Baker Mayfield TB | Owner | Tue Nov 4 5:28pm ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 1:08pm ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 1:08pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 4 1:08pm ET |
| Started | WR | Josh Downs IND | Owner | Tue Nov 4 1:08pm ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Thu Nov 6 10:40pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Tyler Allgeier ATL | Owner | Thu Nov 6 12:19am ET |
| Started | RB | Emari Demercado ARI | Owner | Thu Nov 6 12:19am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 4 11:05pm ET |
| Benched | WR | Keon Coleman BUF | Owner | Tue Nov 4 11:05pm ET |
| Started | RB | Tyler Allgeier ATL | Owner | Tue Nov 4 11:05pm ET |
| Started | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 4 11:05pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Patrick Mahomes KC | Owner | Wed Nov 5 3:14am ET |
| Started | TE | Dallas Goedert PHI | Owner | Wed Nov 5 3:14am ET |
| Started | WR | A.J. Brown PHI | Owner | Wed Nov 5 3:14am ET |
| Started | RB | Breece Hall NYJ | Owner | Wed Nov 5 3:14am ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 5 3:14am ET |
| Benched | K | Jason Myers SEA | Owner | Wed Nov 5 3:14am ET |
| Benched | TE | Travis Kelce KC | Owner | Wed Nov 5 3:14am ET |
| Benched | WR | Khalil Shakir BUF | Owner | Wed Nov 5 3:14am ET |
| Benched | WR | Troy Franklin DEN | Owner | Wed Nov 5 3:14am ET |
| Started | K | Chase McLaughlin TB | Owner | Wed Nov 5 3:14am ET |
| No starting lineup changes performed this week. |
| Started | K | Jake Bates DET | Owner | Thu Nov 6 7:20am ET |
| Benched | K | Brandon Aubrey DAL | Owner | Tue Nov 4 5:12pm ET |
| Benched | TE | Evan Engram DEN | Owner | Tue Nov 4 5:11pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 5:11pm ET |
| Benched | D/ST | Atlanta Falcons ATL | Owner | Tue Nov 4 5:11pm ET |
| Started | D/ST | Seattle Seahawks SEA | Owner | Tue Nov 4 5:11pm ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Thu Nov 6 12:27am ET |
| Benched | TE | Tucker Kraft GB | Owner | Thu Nov 6 12:27am ET |
| Started | WR | Emeka Egbuka TB | Owner | Thu Nov 6 12:27am ET |
| Started | WR | Quentin Johnston LAC | Owner | Thu Nov 6 12:27am ET |
| Benched | WR | Keenan Allen LAC | Owner | Wed Nov 5 6:38pm ET |
| Started | WR | Jordan Addison MIN | Owner | Wed Nov 5 6:38pm ET |
| Benched | K | Harrison Butker KC | Owner | Wed Nov 5 6:36pm ET |
| Started | D/ST | Houston Texans HOU | Owner | Thu Nov 6 7:59pm ET |
| Benched | RB | Chase Brown CIN | Owner | Wed Nov 5 10:32pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Wed Nov 5 10:32pm ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Wed Nov 5 10:32pm ET |
| Benched | TE | Tyler Warren IND | Owner | Wed Nov 5 10:32pm ET |
| Started | RB | Jordan Mason MIN | Owner | Wed Nov 5 10:32pm ET |
| Started | RB | Rachaad White TB | Owner | Wed Nov 5 10:32pm ET |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 5 10:32pm ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Wed Nov 5 10:32pm ET |