

| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 5:51am CT |
| Benched | WR | Jauan Jennings SF | Owner | Sat Nov 29 5:51am CT |
| Started | WR | DeVonta Smith PHI | Owner | Thu Nov 27 3:33pm CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 3:33pm CT |
| Started | WR | Jauan Jennings SF | Owner | Thu Nov 27 8:10am CT |
| Benched | RB | Kenneth Walker III SEA | Owner | Thu Nov 27 8:10am CT |
| Started | RB | Kareem Hunt KC | Owner | Thu Nov 27 8:09am CT |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 8:09am CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 3:43pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 3:43pm CT |
| Benched | QB | Aaron Rodgers PIT | Owner | Thu Nov 27 12:16am CT |
| Started | QB | Cam Ward TEN | Owner | Thu Nov 27 12:16am CT |
| Benched | WR | Tre Tucker LV | Owner | Thu Nov 27 12:16am CT |
| Benched | TE | Pat Freiermuth PIT | Owner | Thu Nov 27 12:16am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 12:16am CT |
| Started | TE | Mason Taylor NYJ | Owner | Thu Nov 27 12:16am CT |
| Benched | RB | Alvin Kamara NO | system | Sun Nov 30 5:28am CT |
| Started | TE | Brenton Strange JAX | system | Sun Nov 30 5:28am CT |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 2:27pm CT |
| Benched | WR | Luther Burden III CHI | Owner | Wed Nov 26 2:27pm CT |
| Benched | WR | Mack Hollins NE | Owner | Wed Nov 26 2:27pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 2:27pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 2:27pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 2:27pm CT |
| Benched | RB | Aaron Jones MIN | Owner | Thu Nov 27 9:38am CT |
| Started | RB | Josh Jacobs GB | Owner | Thu Nov 27 9:38am CT |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 9:46pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 9:46pm CT |
| Started | QB | Dillon Gabriel CLE | system | Sun Nov 30 5:28am CT |
| Benched | QB | J.J. McCarthy MIN | system | Sun Nov 30 5:28am CT |
| Benched | QB | Daniel Jones IND | Owner | Wed Nov 26 7:50am CT |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 7:50am CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 7:49am CT |
| Benched | TE | T.J. Hockenson MIN | Owner | Wed Nov 26 7:49am CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 7:49am CT |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 7:49am CT |
| Benched | WR | Elic Ayomanor TEN | Owner | Thu Nov 27 6:34pm CT |
| Benched | WR | Kyle Williams NE | Owner | Thu Nov 27 6:34pm CT |
| Started | WR | Keenan Allen LAC | Owner | Thu Nov 27 6:34pm CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Thu Nov 27 6:34pm CT |
| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 5:06pm CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 5:06pm CT |
| Benched | TE | Cade Otton TB | Owner | Tue Nov 25 5:06pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 5:06pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 5:06pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 5:06pm CT |
| Started | RB | Sean Tucker TB | Owner | Sun Nov 30 10:09am CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Sun Nov 30 10:09am CT |
| Started | WR | Rashid Shaheed SEA | Owner | Sun Nov 30 10:08am CT |
| Benched | WR | Greg Dortch ARI | Owner | Sun Nov 30 10:08am CT |
| Started | WR | Greg Dortch ARI | Owner | Thu Nov 27 10:35am CT |
| Benched | RB | Sean Tucker TB | Owner | Thu Nov 27 10:35am CT |
| Started | RB | Sean Tucker TB | Owner | Wed Nov 26 9:23pm CT |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 9:23pm CT |
| Started | WR | Chris Godwin TB | Owner | Wed Nov 26 9:23pm CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Wed Nov 26 9:23pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 9:16pm CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 9:16pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 9:16pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 9:16pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | Davis Mills HOU | Owner | Thu Nov 27 10:38am CT |
| Started | WR | Christian Kirk HOU | Owner | Thu Nov 27 10:38am CT |
| Started | TE | Zach Ertz WAS | Owner | Thu Nov 27 10:38am CT |