

| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 9:57am CT |
| Benched | RB | Michael Carter ARI | Owner | Tue Nov 25 2:24pm CT |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 2:24pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 2:24pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 2:24pm CT |
| Benched | WR | Ricky Pearsall SF | Owner | Sat Nov 29 12:25pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Sat Nov 29 12:25pm CT |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 8:30pm CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 8:30pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 8:29pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 8:29pm CT |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Thu Nov 27 10:18am CT |
| Benched | WR | Stefon Diggs NE | Owner | Thu Nov 27 10:18am CT |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Thu Nov 27 10:18am CT |
| Started | RB | Aaron Jones MIN | Owner | Thu Nov 27 10:18am CT |
| Started | WR | Davante Adams LAR | Owner | Thu Nov 27 10:18am CT |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 27 10:18am CT |
| Benched | QB | Daniel Jones IND | Owner | Wed Nov 26 12:06pm CT |
| Started | QB | Trevor Lawrence JAX | Owner | Wed Nov 26 12:06pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 6:54am CT |
| Started | WR | Zay Flowers BAL | Owner | Tue Nov 25 6:54am CT |
| Benched | K | Cam Little JAX | Owner | Tue Nov 25 6:53am CT |
| Started | K | Ka'imi Fairbairn HOU | Owner | Tue Nov 25 6:53am CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 7:15am CT |
| Started | RB | Woody Marks HOU | Owner | Wed Nov 26 2:43pm CT |
| Benched | RB | Bucky Irving TB | Owner | Wed Nov 26 2:43pm CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 11:22am CT |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 11:22am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 3:18pm CT |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 3:18pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 3:17pm CT |
| Benched | TE | Colby Parkinson LAR | Owner | Tue Nov 25 3:17pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 3:17pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 3:17pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Rome Odunze CHI | Owner | Wed Nov 26 12:28pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 12:28pm CT |
| Benched | WR | Quentin Johnston LAC | Owner | Wed Nov 26 12:26pm CT |
| Started | TE | Jake Ferguson DAL | Owner | Wed Nov 26 12:26pm CT |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 25 8:18pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 8:18pm CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 9:10am CT |
| Started | TE | Jake Ferguson DAL | Owner | Tue Nov 25 9:10am CT |
| No starting lineup changes performed this week. |
| Benched | QB | Cam Ward TEN | Owner | Wed Nov 26 11:00am CT |
| Benched | WR | Marquise Brown KC | Owner | Wed Nov 26 11:00am CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Wed Nov 26 11:00am CT |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Wed Nov 26 11:00am CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 11:00am CT |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 11:00am CT |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 11:00am CT |
| Started | D/ST | Indianapolis Colts IND | Owner | Wed Nov 26 11:00am CT |
| Benched | WR | Christian Watson GB | Owner | Wed Nov 26 6:18am CT |
| Benched | TE | Chigoziem Okonkwo TEN | Owner | Wed Nov 26 6:18am CT |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 6:18am CT |
| Started | TE | Evan Engram DEN | Owner | Wed Nov 26 6:18am CT |
| Benched | RB | Rico Dowdle CAR | Owner | Wed Nov 26 10:42am CT |
| Started | RB | Ashton Jeanty LV | Owner | Wed Nov 26 10:42am CT |