

| Benched | WR | Jauan Jennings SF | Owner | Thu Nov 27 9:23am ET |
| Started | WR | D.J. Moore CHI | Owner | Thu Nov 27 9:23am ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Thu Nov 27 9:22am ET |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 9:22am ET |
| Benched | RB | Nick Chubb HOU | Owner | Wed Nov 26 9:06am ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 9:06am ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 9:06am ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 9:06am ET |
| Benched | WR | Emeka Egbuka TB | Owner | Wed Nov 26 1:47pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 1:47pm ET |
| Benched | RB | Tony Pollard TEN | Owner | Wed Nov 26 1:47pm ET |
| Started | RB | Kyle Monangai CHI | Owner | Wed Nov 26 1:47pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Sun Nov 30 9:34am ET |
| Started | RB | Kenneth Walker III SEA | Owner | Sun Nov 30 9:34am ET |
| Benched | RB | Kenneth Walker III SEA | Owner | Sun Nov 30 9:32am ET |
| Started | WR | Justin Jefferson MIN | Owner | Sun Nov 30 9:32am ET |
| Benched | WR | Justin Jefferson MIN | Owner | Sat Nov 29 5:37pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 5:37pm ET |
| Benched | QB | Caleb Williams CHI | Owner | Wed Nov 26 12:07pm ET |
| Started | QB | Dak Prescott DAL | Owner | Wed Nov 26 12:07pm ET |
| No starting lineup changes performed this week. |
| Started | TE | Brock Bowers LV | Owner | Wed Nov 26 8:00am ET |
| Started | WR | Michael Wilson ARI | Owner | Wed Nov 26 8:00am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Wed Nov 26 8:00am ET |
| Started | RB | Bijan Robinson ATL | Owner | Wed Nov 26 8:00am ET |
| Started | RB | Woody Marks HOU | Owner | Wed Nov 26 8:00am ET |
| Started | RB | Saquon Barkley PHI | Owner | Wed Nov 26 8:00am ET |
| Started | QB | Jared Goff DET | Owner | Wed Nov 26 8:00am ET |
| Benched | TE | Hunter Henry NE | Owner | Wed Nov 26 8:00am ET |
| Benched | WR | Xavier Legette CAR | Owner | Wed Nov 26 8:00am ET |
| Benched | WR | Chris Godwin TB | Owner | Wed Nov 26 8:00am ET |
| Benched | WR | Chimere Dike TEN | Owner | Wed Nov 26 8:00am ET |
| Benched | RB | Isiah Pacheco KC | Owner | Wed Nov 26 8:00am ET |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Wed Nov 26 8:00am ET |
| Benched | QB | Bryce Young CAR | Owner | Wed Nov 26 8:00am ET |
| Started | RB | Isiah Pacheco KC | Owner | Tue Nov 25 3:07pm ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Tue Nov 25 3:07pm ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 3:07pm ET |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Nov 25 3:07pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Sat Nov 29 5:48pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Sat Nov 29 5:48pm ET |
| Benched | RB | David Montgomery DET | Owner | Thu Nov 27 12:05pm ET |
| Started | WR | Jordan Addison MIN | Owner | Thu Nov 27 12:05pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 4:08pm ET |
| Started | WR | Darnell Mooney ATL | Owner | Tue Nov 25 4:08pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 2:39am ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 2:39am ET |
| Benched | WR | Josh Downs IND | Owner | Thu Nov 27 12:35pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Thu Nov 27 12:35pm ET |
| Started | K | Jake Bates DET | Owner | Thu Nov 27 12:35pm ET |
| Started | K | Cameron Dicker LAC | Owner | Sat Nov 29 7:55am ET |
| Started | RB | Trey Benson ARI | Owner | Tue Nov 25 4:41pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 4:41pm ET |
| Benched | WR | Troy Franklin DEN | Owner | Tue Nov 25 4:40pm ET |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 4:40pm ET |
| Benched | QB | Jayden Daniels WAS | Owner | Tue Nov 25 4:39pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 4:39pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 4:39pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 4:39pm ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 1:14am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 7:25am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:25am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 7:25am ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 7:25am ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 7:25am ET |
| Benched | TE | Brenton Strange JAX | Owner | Tue Nov 25 7:25am ET |
| Benched | WR | Luther Burden III CHI | Owner | Tue Nov 25 7:25am ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 7:25am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 7:25am ET |
| Benched | QB | Cam Ward TEN | Owner | Tue Nov 25 7:25am ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 9:13am ET |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 25 9:09am ET |
| Started | TE | Colston Loveland CHI | Owner | Tue Nov 25 9:09am ET |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 25 9:09am ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Nov 25 9:09am ET |