

| Benched | WR | Drake London ATL | Owner | Sat Nov 29 8:38pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Sat Nov 29 8:38pm CT |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 11:25am CT |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 11:25am CT |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 11:23am CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 11:23am CT |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 7:27am CT |
| Started | RB | Travis Etienne JAX | Owner | Tue Nov 25 7:27am CT |
| Benched | WR | Kayshon Boutte NE | Owner | Wed Nov 26 6:03pm CT |
| Benched | WR | Parker Washington JAX | Owner | Wed Nov 26 6:03pm CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Wed Nov 26 6:03pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 6:03pm CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 5:07pm CT |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 5:07pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 5:07pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 5:07pm CT |
| Started | WR | Alec Pierce IND | Owner | Tue Nov 25 5:07pm CT |
| Started | WR | Christian Watson GB | Owner | Tue Nov 25 5:07pm CT |
| Benched | WR | Calvin Austin III PIT | Owner | Tue Nov 25 12:40pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 12:40pm CT |
| Started | RB | Emanuel Wilson GB | Owner | Thu Nov 27 1:37am CT |
| Benched | RB | Kyle Monangai CHI | Owner | Thu Nov 27 1:37am CT |
| Started | RB | Kyle Monangai CHI | Owner | Thu Nov 27 1:15am CT |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 1:15am CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 7:27pm CT |
| Benched | RB | Kyle Monangai CHI | Owner | Wed Nov 26 7:27pm CT |
| Started | WR | Darius Slayton NYG | Owner | Tue Nov 25 2:35pm CT |
| Benched | WR | Xavier Hutchinson HOU | Owner | Tue Nov 25 2:35pm CT |
| Started | TE | Jonnu Smith PIT | Owner | Tue Nov 25 1:31pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 1:31pm CT |
| Benched | TE | Noah Fant CIN | Owner | Tue Nov 25 1:31pm CT |
| Benched | WR | Xavier Legette CAR | Owner | Tue Nov 25 1:31pm CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Sat Nov 29 11:48pm CT |
| Benched | RB | Tyjae Spears TEN | Owner | Sat Nov 29 11:48pm CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 26 9:06pm CT |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 9:06pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 9:06pm CT |
| Started | QB | Max Brosmer MIN | Owner | Wed Nov 26 9:06pm CT |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Wed Nov 26 9:06pm CT |
| Benched | WR | D.J. Moore CHI | Owner | Wed Nov 26 9:06pm CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Wed Nov 26 9:06pm CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 9:06pm CT |
| Benched | RB | Jaleel McLaughlin DEN | Owner | Thu Nov 27 7:16am CT |
| Started | RB | Rhamondre Stevenson NE | Owner | Thu Nov 27 7:16am CT |
| Benched | QB | Tyrod Taylor NYJ | Owner | Wed Nov 26 8:50pm CT |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 8:50pm CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Wed Nov 26 10:56am CT |
| Benched | WR | Luther Burden III CHI | Owner | Wed Nov 26 10:56am CT |
| Started | RB | Jaleel McLaughlin DEN | Owner | Wed Nov 26 10:56am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 10:56am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Bhayshul Tuten JAX | Owner | Thu Nov 27 5:49pm CT |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 5:49pm CT |
| Benched | QB | Davis Mills HOU | Owner | Thu Nov 27 5:49pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Thu Nov 27 5:49pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 11:48am CT |
| Started | QB | Trevor Lawrence JAX | Owner | Thu Nov 27 11:48am CT |
| Benched | QB | Kirk Cousins ATL | Owner | Tue Nov 25 6:37am CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 6:37am CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 6:37am CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 6:37am CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 6:37am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 6:37am CT |