

| Started | WR | Tre Tucker LV | Owner | Thu Nov 27 11:37am CT |
| Benched | WR | Christian Kirk HOU | Owner | Thu Nov 27 11:37am CT |
| Started | WR | Christian Kirk HOU | Owner | Wed Nov 26 11:50pm CT |
| Benched | WR | Tre Tucker LV | Owner | Wed Nov 26 11:50pm CT |
| Started | WR | Tre Tucker LV | Owner | Tue Nov 25 12:30pm CT |
| Started | WR | Darnell Mooney ATL | Owner | Tue Nov 25 12:30pm CT |
| Benched | WR | Christian Kirk HOU | Owner | Tue Nov 25 12:30pm CT |
| Benched | RB | Chris Rodriguez Jr. WAS | Owner | Tue Nov 25 12:30pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 7:03am CT |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Tue Nov 25 7:03am CT |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 7:03am CT |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 7:03am CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 7:08pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 7:08pm CT |
| Benched | WR | Luther Burden III CHI | Owner | Tue Nov 25 12:34pm CT |
| Benched | TE | Cade Otton TB | Owner | Tue Nov 25 12:34pm CT |
| Started | WR | Pat Bryant DEN | Owner | Tue Nov 25 12:34pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 12:34pm CT |
| No starting lineup changes performed this week. |
| Benched | TE | Oronde Gadsden II LAC | Owner | Sat Nov 29 5:35pm CT |
| Started | TE | Theo Johnson NYG | Owner | Sat Nov 29 5:35pm CT |
| Benched | TE | Theo Johnson NYG | Owner | Thu Nov 27 9:40am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Thu Nov 27 9:40am CT |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 9:39am CT |
| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 1:11pm CT |
| Benched | WR | Marquise Brown KC | Owner | Wed Nov 26 7:30pm CT |
| Benched | WR | Xavier Legette CAR | Owner | Tue Nov 25 10:23am CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 10:23am CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 10:23am CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 10:23am CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 8:12pm CT |
| Started | QB | Dak Prescott DAL | Owner | Tue Nov 25 8:12pm CT |
| Benched | WR | Cooper Kupp SEA | Owner | Wed Nov 26 9:09pm CT |
| Started | WR | John Metchie III NYJ | Owner | Wed Nov 26 9:09pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 7:22pm CT |
| Benched | D/ST | Cleveland Browns CLE | Owner | Wed Nov 26 7:22pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 7:22pm CT |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 7:22pm CT |
| Benched | WR | Jameson Williams DET | Owner | Wed Nov 26 9:04pm CT |
| Started | WR | Christian Watson GB | Owner | Wed Nov 26 9:04pm CT |
| Benched | QB | Jordan Love GB | Owner | Wed Nov 26 9:03pm CT |
| Started | QB | Brock Purdy SF | Owner | Wed Nov 26 9:03pm CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Wed Nov 26 9:00pm CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 6:27pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 6:27pm CT |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 6:13am CT |
| Started | QB | Jordan Love GB | Owner | Tue Nov 25 6:13am CT |
| Benched | WR | Darius Slayton NYG | Owner | Sat Nov 29 7:58pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 7:58pm CT |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 25 10:02pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 10:02pm CT |
| Benched | WR | Rome Odunze CHI | Owner | Thu Nov 27 8:23am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 8:23am CT |
| Benched | RB | Woody Marks HOU | Owner | Thu Nov 27 8:23am CT |
| Benched | RB | David Montgomery DET | Owner | Thu Nov 27 8:23am CT |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Thu Nov 27 8:23am CT |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 8:23am CT |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 8:23am CT |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 8:23am CT |
| Started | D/ST | Atlanta Falcons ATL | Owner | Thu Nov 27 8:23am CT |