

| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 10:58am CT |
| Benched | WR | Tre Tucker LV | Owner | Thu Nov 27 10:58am CT |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 10:58am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 10:58am CT |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 11:05am CT |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 11:05am CT |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 11:05am CT |
| Started | RB | Kimani Vidal LAC | Owner | Wed Nov 26 11:05am CT |
| Benched | QB | Brock Purdy SF | Owner | Sun Nov 30 10:14am CT |
| Started | QB | C.J. Stroud HOU | Owner | Sun Nov 30 10:14am CT |
| Benched | RB | D'Andre Swift CHI | Owner | Thu Nov 27 10:58am CT |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 10:58am CT |
| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 10:49am CT |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 10:49am CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 10:43am CT |
| Started | RB | Tyjae Spears TEN | Owner | Tue Nov 25 10:43am CT |
| Benched | WR | Jalen Coker CAR | Owner | Wed Nov 26 7:56am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 7:56am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Emeka Egbuka TB | Owner | Wed Nov 26 8:02pm CT |
| Started | WR | Kayshon Boutte NE | Owner | Wed Nov 26 8:02pm CT |
| Benched | RB | Aaron Jones MIN | Owner | Wed Nov 26 8:00pm CT |
| Benched | TE | Hunter Henry NE | Owner | Wed Nov 26 8:00pm CT |
| Benched | TE | Kyle Pitts ATL | Owner | Wed Nov 26 8:00pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 8:00pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 8:00pm CT |
| Started | TE | T.J. Hockenson MIN | Owner | Wed Nov 26 8:00pm CT |
| Benched | QB | Kirk Cousins ATL | Owner | Sun Nov 30 3:44am CT |
| Benched | WR | Chimere Dike TEN | Owner | Sun Nov 30 3:44am CT |
| Started | QB | Aaron Rodgers PIT | Owner | Sun Nov 30 3:44am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Sun Nov 30 3:44am CT |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 10:37am CT |
| Benched | TE | Mason Taylor NYJ | Owner | Wed Nov 26 10:37am CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 10:37am CT |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Wed Nov 26 10:37am CT |
| Benched | QB | Teddy Bridgewater TB | Owner | Sun Nov 30 1:12am CT |
| Started | QB | Max Brosmer MIN | Owner | Sun Nov 30 1:12am CT |
| Benched | QB | Jameis Winston NYG | Owner | Thu Nov 27 2:17am CT |
| Started | QB | Teddy Bridgewater TB | Owner | Thu Nov 27 2:17am CT |
| Started | WR | Cooper Kupp SEA | Owner | Wed Nov 26 12:54am CT |
| Benched | WR | DeAndre Hopkins BAL | Owner | Wed Nov 26 12:54am CT |
| Benched | WR | Cooper Kupp SEA | Owner | Wed Nov 26 12:54am CT |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 12:54am CT |
| No starting lineup changes performed this week. |
| Benched | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 10:35pm CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 10:35pm CT |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 1:45pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 1:45pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 1:45pm CT |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 1:45pm CT |
| Started | WR | Greg Dortch ARI | Owner | Thu Nov 27 5:49pm CT |
| Benched | WR | Greg Dortch ARI | Owner | Thu Nov 27 5:49pm CT |
| Benched | WR | Ricky Pearsall SF | Owner | Thu Nov 27 5:49pm CT |
| Benched | TE | Colston Loveland CHI | Owner | Thu Nov 27 5:49pm CT |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 5:49pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Thu Nov 27 5:49pm CT |
| Benched | WR | Luther Burden III CHI | Owner | Thu Nov 27 2:34pm CT |
| Started | WR | Greg Dortch ARI | Owner | Thu Nov 27 2:34pm CT |