

| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 11:58am ET |
| Benched | WR | Tre Tucker LV | Owner | Thu Nov 27 11:58am ET |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 11:58am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 11:58am ET |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 12:05pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 12:05pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 12:05pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Wed Nov 26 12:05pm ET |
| Benched | RB | D'Andre Swift CHI | Owner | Thu Nov 27 11:58am ET |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 11:58am ET |
| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 11:49am ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 11:49am ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 11:43am ET |
| Started | RB | Tyjae Spears TEN | Owner | Tue Nov 25 11:43am ET |
| Benched | WR | Jalen Coker CAR | Owner | Wed Nov 26 8:56am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 8:56am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Emeka Egbuka TB | Owner | Wed Nov 26 9:02pm ET |
| Started | WR | Kayshon Boutte NE | Owner | Wed Nov 26 9:02pm ET |
| Benched | RB | Aaron Jones MIN | Owner | Wed Nov 26 9:00pm ET |
| Benched | TE | Hunter Henry NE | Owner | Wed Nov 26 9:00pm ET |
| Benched | TE | Kyle Pitts ATL | Owner | Wed Nov 26 9:00pm ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 9:00pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 9:00pm ET |
| Started | TE | T.J. Hockenson MIN | Owner | Wed Nov 26 9:00pm ET |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 11:37am ET |
| Benched | TE | Mason Taylor NYJ | Owner | Wed Nov 26 11:37am ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 11:37am ET |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Wed Nov 26 11:37am ET |
| Benched | QB | Jameis Winston NYG | Owner | Thu Nov 27 3:17am ET |
| Started | QB | Teddy Bridgewater TB | Owner | Thu Nov 27 3:17am ET |
| Started | WR | Cooper Kupp SEA | Owner | Wed Nov 26 1:54am ET |
| Benched | WR | DeAndre Hopkins BAL | Owner | Wed Nov 26 1:54am ET |
| Benched | WR | Cooper Kupp SEA | Owner | Wed Nov 26 1:54am ET |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 1:54am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 11:35pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 11:35pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 2:45pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 2:45pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 2:45pm ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 2:45pm ET |
| Started | WR | Greg Dortch ARI | Owner | Thu Nov 27 6:49pm ET |
| Benched | WR | Greg Dortch ARI | Owner | Thu Nov 27 6:49pm ET |
| Benched | WR | Ricky Pearsall SF | Owner | Thu Nov 27 6:49pm ET |
| Benched | TE | Colston Loveland CHI | Owner | Thu Nov 27 6:49pm ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 6:49pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Thu Nov 27 6:49pm ET |
| Benched | WR | Luther Burden III CHI | Owner | Thu Nov 27 3:34pm ET |
| Started | WR | Greg Dortch ARI | Owner | Thu Nov 27 3:34pm ET |