

| No starting lineup changes performed this week. |
| Benched | D/ST | Green Bay Packers GB | Owner | Tue Oct 28 7:33pm CT |
| Started | D/ST | Detroit Lions DET | Owner | Tue Oct 28 7:33pm CT |
| Benched | QB | Mac Jones SF | Owner | Tue Oct 28 7:32pm CT |
| Benched | RB | Justice Hill BAL | Owner | Tue Oct 28 7:32pm CT |
| Benched | WR | Jauan Jennings SF | Owner | Tue Oct 28 7:32pm CT |
| Started | QB | Brock Purdy SF | Owner | Tue Oct 28 7:32pm CT |
| Started | RB | Jahmyr Gibbs DET | Owner | Tue Oct 28 7:32pm CT |
| Started | WR | Nico Collins HOU | Owner | Tue Oct 28 7:32pm CT |
| Benched | TE | George Kittle SF | Owner | Wed Oct 29 11:29am CT |
| Started | TE | Tucker Kraft GB | Owner | Wed Oct 29 11:29am CT |
| Benched | QB | Jayden Daniels WAS | Owner | Tue Oct 28 7:14am CT |
| Started | QB | Jared Goff DET | Owner | Tue Oct 28 7:14am CT |
| Benched | RB | Rachaad White TB | Owner | Tue Oct 28 6:25am CT |
| Started | QB | Jayden Daniels WAS | Owner | Tue Oct 28 6:25am CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Oct 28 6:25am CT |
| Benched | RB | Breece Hall NYJ | Owner | Tue Oct 28 9:13am CT |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Oct 28 9:13am CT |
| Benched | K | Jake Elliott PHI | Owner | Tue Oct 28 9:13am CT |
| Started | RB | Tahj Brooks CIN | Owner | Tue Oct 28 9:13am CT |
| Started | RB | Jarquez Hunter LAR | Owner | Tue Oct 28 9:13am CT |
| Started | WR | Drake London ATL | Owner | Tue Oct 28 9:13am CT |
| Benched | WR | Quentin Johnston LAC | Owner | Wed Oct 29 10:12am CT |
| Benched | TE | Juwan Johnson NO | Owner | Wed Oct 29 10:12am CT |
| Started | WR | Travis Hunter JAX | Owner | Wed Oct 29 10:12am CT |
| Started | TE | Brock Bowers LV | Owner | Wed Oct 29 10:12am CT |
| No starting lineup changes performed this week. |
| Benched | QB | Spencer Rattler NO | Owner | Wed Oct 29 9:05am CT |
| Started | QB | Sam Darnold SEA | Owner | Wed Oct 29 9:05am CT |
| Benched | WR | Tez Johnson TB | Owner | Tue Oct 28 7:44pm CT |
| Started | WR | D.J. Moore CHI | Owner | Tue Oct 28 7:44pm CT |
| Benched | QB | Jaxson Dart NYG | Owner | Tue Oct 28 9:35am CT |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Oct 28 9:35am CT |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Oct 28 9:35am CT |
| Started | QB | Lamar Jackson BAL | Owner | Tue Oct 28 9:35am CT |
| Started | RB | Kyren Williams LAR | Owner | Tue Oct 28 9:35am CT |
| Started | TE | Kyle Pitts ATL | Owner | Tue Oct 28 9:35am CT |
| Benched | WR | Calvin Austin III PIT | Owner | Wed Oct 29 5:25am CT |
| Benched | WR | Marvin Mims DEN | Owner | Wed Oct 29 5:25am CT |
| Benched | TE | Noah Gray KC | Owner | Wed Oct 29 5:25am CT |
| Started | RB | Kareem Hunt KC | Owner | Wed Oct 29 5:25am CT |
| Started | WR | Amon-Ra St. Brown DET | Owner | Wed Oct 29 5:25am CT |
| Started | TE | Trey McBride ARI | Owner | Wed Oct 29 5:25am CT |
| Benched | WR | Keon Coleman BUF | Owner | Wed Oct 29 12:41am CT |
| Started | WR | Jameson Williams DET | Owner | Wed Oct 29 12:41am CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Oct 28 9:39am CT |
| Started | QB | Matthew Stafford LAR | Owner | Tue Oct 28 9:39am CT |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Oct 28 9:39am CT |
| Started | WR | Davante Adams LAR | Owner | Tue Oct 28 9:39am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Stefon Diggs NE | Owner | Tue Oct 28 1:45pm CT |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 1:45pm CT |
| Benched | WR | Josh Downs IND | Owner | Tue Oct 28 1:45pm CT |
| Benched | WR | Xavier Worthy KC | Owner | Tue Oct 28 1:45pm CT |
| Benched | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Oct 28 1:45pm CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Oct 28 1:45pm CT |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 28 1:45pm CT |
| Started | D/ST | Los Angeles Rams LAR | Owner | Tue Oct 28 1:45pm CT |