

| Started | D/ST | Arizona Cardinals ARI | Owner | Thu Nov 27 3:54pm ET |
| Benched | D/ST | Detroit Lions DET | Owner | Wed Nov 26 3:05pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 3:05pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 3:05pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 3:05pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 3:05pm ET |
| Benched | TE | Dalton Schultz HOU | Owner | Wed Nov 26 3:05pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Wed Nov 26 3:05pm ET |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 3:05pm ET |
| Benched | QB | Daniel Jones IND | Owner | Wed Nov 26 3:05pm ET |
| Benched | TE | Cade Otton TB | Owner | Thu Nov 27 9:23am ET |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 9:23am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 9:12pm ET |
| Benched | K | Cam Little JAX | Owner | Tue Nov 25 9:12pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 9:12pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 9:12pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 27 11:21am ET |
| Started | RB | Tyjae Spears TEN | Owner | Thu Nov 27 11:21am ET |
| Benched | WR | Chris Olave NO | Owner | Sun Nov 30 12:35pm ET |
| Started | RB | Bucky Irving TB | Owner | Sun Nov 30 12:35pm ET |
| Started | D/ST | Los Angeles Chargers LAC | system | Sun Nov 30 4:42am ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 12:03pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 25 12:03pm ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 12:03pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 25 12:03pm ET |
| Benched | D/ST | Buffalo Bills BUF | Owner | Thu Nov 27 11:30am ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Thu Nov 27 11:30am ET |
| Benched | WR | Elic Ayomanor TEN | Owner | Thu Nov 27 7:54pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 7:54pm ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 27 1:35am ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 1:35am ET |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Thu Nov 27 1:35am ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 11:57am ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 11:57am ET |
| Benched | RB | Keaton Mitchell BAL | Owner | Tue Nov 25 11:57am ET |
| Benched | QB | Caleb Williams CHI | Owner | Tue Nov 25 11:57am ET |
| Started | TE | Dalton Kincaid BUF | Owner | Tue Nov 25 11:56am ET |
| Benched | TE | Isaiah Likely BAL | Owner | Tue Nov 25 11:56am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 11:56am ET |
| Benched | WR | Rome Odunze CHI | Owner | Tue Nov 25 11:56am ET |
| Benched | RB | Michael Carter ARI | Owner | Wed Nov 26 11:43pm ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 11:43pm ET |
| Benched | D/ST | Minnesota Vikings MIN | Owner | Wed Nov 26 5:53pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 5:53pm ET |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 25 3:25pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 3:25pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Wed Nov 26 9:46am ET |
| Started | QB | Jordan Love GB | Owner | Wed Nov 26 9:46am ET |
| Benched | RB | Brian Robinson Jr. SF | Owner | Wed Nov 26 9:46am ET |
| Benched | QB | Jaxson Dart NYG | Owner | Wed Nov 26 9:46am ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 3:09pm ET |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 25 3:09pm ET |
| Started | RB | Brian Robinson Jr. SF | Owner | Tue Nov 25 3:08pm ET |
| Benched | RB | Brashard Smith KC | Owner | Tue Nov 25 3:08pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 2:16pm ET |
| Benched | RB | Brian Robinson Jr. SF | Owner | Tue Nov 25 2:16pm ET |
| No starting lineup changes performed this week. |