

| Started | D/ST | Arizona Cardinals ARI | Owner | Thu Nov 27 2:54pm CT |
| Benched | D/ST | Detroit Lions DET | Owner | Wed Nov 26 2:05pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 2:05pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 2:05pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 2:05pm CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 2:05pm CT |
| Benched | TE | Dalton Schultz HOU | Owner | Wed Nov 26 2:05pm CT |
| Benched | WR | DeVonta Smith PHI | Owner | Wed Nov 26 2:05pm CT |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 2:05pm CT |
| Benched | QB | Daniel Jones IND | Owner | Wed Nov 26 2:05pm CT |
| Benched | TE | Cade Otton TB | Owner | Thu Nov 27 8:23am CT |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 8:23am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:12pm CT |
| Benched | K | Cam Little JAX | Owner | Tue Nov 25 8:12pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 8:12pm CT |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 8:12pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 27 10:21am CT |
| Started | RB | Tyjae Spears TEN | Owner | Thu Nov 27 10:21am CT |
| Benched | WR | Chris Olave NO | Owner | Sun Nov 30 11:35am CT |
| Started | RB | Bucky Irving TB | Owner | Sun Nov 30 11:35am CT |
| Started | D/ST | Los Angeles Chargers LAC | system | Sun Nov 30 3:42am CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 11:03am CT |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 25 11:03am CT |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 11:03am CT |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 25 11:03am CT |
| Benched | D/ST | Buffalo Bills BUF | Owner | Thu Nov 27 10:30am CT |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Thu Nov 27 10:30am CT |
| Benched | WR | Elic Ayomanor TEN | Owner | Thu Nov 27 6:54pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 6:54pm CT |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 27 12:35am CT |
| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 12:35am CT |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Thu Nov 27 12:35am CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 10:57am CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 10:57am CT |
| Benched | RB | Keaton Mitchell BAL | Owner | Tue Nov 25 10:57am CT |
| Benched | QB | Caleb Williams CHI | Owner | Tue Nov 25 10:57am CT |
| Started | TE | Dalton Kincaid BUF | Owner | Tue Nov 25 10:56am CT |
| Benched | TE | Isaiah Likely BAL | Owner | Tue Nov 25 10:56am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 10:56am CT |
| Benched | WR | Rome Odunze CHI | Owner | Tue Nov 25 10:56am CT |
| Benched | RB | Michael Carter ARI | Owner | Wed Nov 26 10:43pm CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 10:43pm CT |
| Benched | D/ST | Minnesota Vikings MIN | Owner | Wed Nov 26 4:53pm CT |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 4:53pm CT |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 25 2:25pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 2:25pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Wed Nov 26 8:46am CT |
| Started | QB | Jordan Love GB | Owner | Wed Nov 26 8:46am CT |
| Benched | RB | Brian Robinson Jr. SF | Owner | Wed Nov 26 8:46am CT |
| Benched | QB | Jaxson Dart NYG | Owner | Wed Nov 26 8:46am CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 2:09pm CT |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 25 2:09pm CT |
| Started | RB | Brian Robinson Jr. SF | Owner | Tue Nov 25 2:08pm CT |
| Benched | RB | Brashard Smith KC | Owner | Tue Nov 25 2:08pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 1:16pm CT |
| Benched | RB | Brian Robinson Jr. SF | Owner | Tue Nov 25 1:16pm CT |
| No starting lineup changes performed this week. |