

| Benched | QB | Jared Goff DET | Owner | Tue Dec 9 11:12pm ET |
| Benched | RB | Isiah Pacheco KC | Owner | Tue Dec 9 11:12pm ET |
| Started | QB | Drake Maye NE | Owner | Tue Dec 9 11:12pm ET |
| Started | RB | Christian McCaffrey SF | Owner | Tue Dec 9 11:12pm ET |
| Started | D/ST | Kansas City Chiefs KC | Owner | Thu Dec 11 1:12am ET |
| Benched | TE | Dalton Kincaid BUF | Owner | Tue Dec 9 6:51pm ET |
| Started | TE | Hunter Henry NE | Owner | Tue Dec 9 6:51pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Keenan Allen LAC | Owner | Tue Dec 9 5:22pm ET |
| Benched | WR | D.J. Moore CHI | Owner | Tue Dec 9 5:22pm ET |
| Benched | D/ST | Los Angeles Rams LAR | Owner | Tue Dec 9 5:22pm ET |
| Started | RB | TreVeyon Henderson NE | Owner | Tue Dec 9 5:22pm ET |
| Started | WR | Stefon Diggs NE | Owner | Tue Dec 9 5:22pm ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Dec 9 5:22pm ET |
| Benched | RB | Tony Pollard TEN | Owner | Sun Dec 14 10:44am ET |
| Started | RB | Kimani Vidal LAC | Owner | Sun Dec 14 10:44am ET |
| Benched | RB | Kimani Vidal LAC | Owner | Thu Dec 11 5:14am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Thu Dec 11 5:14am ET |
| Benched | WR | Khalil Shakir BUF | Owner | Thu Dec 11 5:13am ET |
| Started | WR | Chris Godwin TB | Owner | Thu Dec 11 5:13am ET |
| Started | WR | Ricky Pearsall SF | Owner | Thu Dec 11 9:12pm ET |
| Benched | WR | Marvin Harrison Jr. ARI | Owner | Thu Dec 11 9:12pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Wed Dec 10 9:03pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Wed Dec 10 9:03pm ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Wed Dec 10 9:02pm ET |
| Started | QB | Jacoby Brissett ARI | Owner | Wed Dec 10 9:02pm ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Wed Dec 10 9:02pm ET |
| Benched | QB | Jayden Daniels WAS | Owner | Wed Dec 10 9:02pm ET |
| Started | RB | Omarion Hampton LAC | Owner | Tue Dec 9 4:02pm ET |
| Benched | RB | Breece Hall NYJ | Owner | Tue Dec 9 4:02pm ET |
| Started | WR | Jauan Jennings SF | Owner | Tue Dec 9 4:01pm ET |
| Benched | WR | Olamide Zaccheaus CHI | Owner | Tue Dec 9 4:01pm ET |
| Benched | QB | Matthew Stafford LAR | Owner | Wed Dec 10 8:28am ET |
| Benched | RB | Devon Achane MIA | Owner | Wed Dec 10 8:28am ET |
| Benched | RB | Chris Rodriguez Jr. WAS | Owner | Wed Dec 10 8:28am ET |
| Benched | WR | Justin Jefferson MIN | Owner | Wed Dec 10 8:28am ET |
| Benched | WR | Terry McLaurin WAS | Owner | Wed Dec 10 8:28am ET |
| Benched | WR | Jaxon Smith-Njigba SEA | Owner | Wed Dec 10 8:28am ET |
| Benched | TE | Kyle Pitts ATL | Owner | Wed Dec 10 8:28am ET |
| Benched | K | Cam Little JAX | Owner | Wed Dec 10 8:28am ET |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Wed Dec 10 8:28am ET |
| Started | D/ST | Dallas Cowboys DAL | Owner | Sun Dec 14 12:51am ET |
| Benched | RB | Jaylen Warren PIT | Owner | Wed Dec 10 10:15pm ET |
| Started | RB | Woody Marks HOU | Owner | Wed Dec 10 10:15pm ET |
| Benched | D/ST | Detroit Lions DET | Owner | Thu Dec 11 8:48am ET |
| Started | D/ST | San Francisco 49ers SF | Owner | Thu Dec 11 8:48am ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Dec 9 10:11am ET |
| Started | RB | Rhamondre Stevenson NE | Owner | Tue Dec 9 10:11am ET |
| Benched | QB | Bo Nix DEN | Owner | Sun Dec 14 12:55pm ET |
| Benched | WR | Adonai Mitchell NYJ | Owner | Sun Dec 14 12:55pm ET |
| Benched | TE | Mason Taylor NYJ | Owner | Sun Dec 14 12:55pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Sun Dec 14 12:55pm ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Sun Dec 14 12:55pm ET |
| Started | TE | George Kittle SF | Owner | Sun Dec 14 12:55pm ET |
| Benched | RB | Jerome Ford CLE | Owner | Tue Dec 9 7:23pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Dec 9 7:23pm ET |
| Started | RB | Chuba Hubbard CAR | Owner | Tue Dec 9 7:23pm ET |
| Started | WR | Tetairoa McMillan CAR | Owner | Tue Dec 9 7:23pm ET |