

| Benched | QB | Mac Jones SF | Owner | Tue Oct 28 7:13pm ET |
| Benched | WR | Marquise Brown KC | Owner | Tue Oct 28 7:13pm ET |
| Benched | TE | Cade Otton TB | Owner | Tue Oct 28 7:13pm ET |
| Started | QB | Lamar Jackson BAL | Owner | Tue Oct 28 7:13pm ET |
| Started | RB | Kyren Williams LAR | Owner | Tue Oct 28 7:13pm ET |
| Started | TE | Sam LaPorta DET | Owner | Tue Oct 28 7:13pm ET |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Oct 28 10:31am ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Oct 28 10:31am ET |
| Benched | RB | Rachaad White TB | Owner | Tue Oct 28 10:31am ET |
| Benched | WR | Matthew Golden GB | Owner | Tue Oct 28 10:31am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Jordan Mason MIN | Owner | Tue Oct 28 11:19am ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Oct 28 11:19am ET |
| Started | RB | Zonovan Knight ARI | Owner | Tue Oct 28 11:19am ET |
| Started | WR | Jameson Williams DET | Owner | Tue Oct 28 11:19am ET |
| Benched | QB | C.J. Stroud HOU | Owner | Tue Oct 28 7:42am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Oct 28 7:42am ET |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 28 7:42am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Oct 28 7:42am ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 7:42am ET |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Oct 28 7:42am ET |
| Started | QB | Sam Darnold SEA | Owner | Tue Oct 28 7:42am ET |
| Benched | TE | Zach Ertz WAS | Owner | Tue Oct 28 7:42am ET |
| Benched | WR | Kyle Williams NE | Owner | Tue Oct 28 7:42am ET |
| Benched | WR | Khalil Shakir BUF | Owner | Tue Oct 28 7:42am ET |
| Benched | WR | Josh Downs IND | Owner | Tue Oct 28 7:42am ET |
| Benched | RB | Isiah Pacheco KC | Owner | Tue Oct 28 7:42am ET |
| Benched | RB | Tyler Allgeier ATL | Owner | Tue Oct 28 7:42am ET |
| Started | TE | Brock Bowers LV | Owner | Tue Oct 28 7:42am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Spencer Rattler NO | Owner | Tue Oct 28 4:18pm ET |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Oct 28 4:18pm ET |
| Benched | WR | Calvin Austin III PIT | Owner | Tue Oct 28 4:18pm ET |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Oct 28 4:18pm ET |
| Started | QB | Kyler Murray ARI | Owner | Tue Oct 28 4:18pm ET |
| Started | RB | Tony Pollard TEN | Owner | Tue Oct 28 4:18pm ET |
| Started | WR | Ricky Pearsall SF | Owner | Tue Oct 28 4:18pm ET |
| Started | WR | Tre Tucker LV | Owner | Tue Oct 28 4:18pm ET |
| Benched | QB | Tyler Huntley BAL | Owner | Tue Oct 28 8:17am ET |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Oct 28 8:17am ET |
| Benched | TE | Juwan Johnson NO | Owner | Tue Oct 28 8:17am ET |
| Started | QB | Drake Maye NE | Owner | Tue Oct 28 8:17am ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Oct 28 8:17am ET |
| Started | TE | Trey McBride ARI | Owner | Tue Oct 28 8:17am ET |
| Benched | QB | Andy Dalton CAR | Owner | Tue Oct 28 9:30am ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Oct 28 9:30am ET |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Oct 28 9:30am ET |
| Started | QB | J.J. McCarthy MIN | Owner | Tue Oct 28 9:30am ET |
| Started | WR | Davante Adams LAR | Owner | Tue Oct 28 9:30am ET |
| Started | TE | Theo Johnson NYG | Owner | Tue Oct 28 9:30am ET |
| Benched | QB | Carson Wentz MIN | Owner | Tue Oct 28 1:34pm ET |
| Benched | RB | Kenneth Gainwell PIT | Owner | Tue Oct 28 1:34pm ET |
| Benched | WR | Marvin Mims DEN | Owner | Tue Oct 28 1:34pm ET |
| Started | RB | Travis Etienne JAX | Owner | Tue Oct 28 1:34pm ET |
| Started | WR | Puka Nacua LAR | Owner | Tue Oct 28 1:34pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Oct 28 1:34pm ET |
| Benched | QB | Jalen Hurts PHI | Owner | Tue Oct 28 8:25am ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Oct 28 8:25am ET |
| Started | QB | Michael Penix Jr. ATL | Owner | Tue Oct 28 8:25am ET |
| Started | WR | Drake London ATL | Owner | Tue Oct 28 8:25am ET |