

| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 8:05pm ET |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 8:05pm ET |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 8:05pm ET |
| Started | QB | Aaron Rodgers PIT | Owner | Tue Nov 25 8:05pm ET |
| Started | WR | Luther Burden III CHI | Owner | Tue Nov 25 8:05pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 8:05pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 3:15pm ET |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 3:15pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 8:55am ET |
| Started | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 8:55am ET |
| Benched | WR | Mack Hollins NE | Owner | Wed Nov 26 10:18am ET |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 10:18am ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 1:15pm ET |
| Started | WR | Chimere Dike TEN | Owner | Tue Nov 25 1:15pm ET |
| Started | QB | Marcus Mariota WAS | Owner | Fri Nov 28 3:10pm ET |
| Benched | QB | Bryce Young CAR | Owner | Fri Nov 28 3:10pm ET |
| Started | WR | Keenan Allen LAC | Owner | Thu Nov 27 11:52am ET |
| Benched | RB | Omarion Hampton LAC | Owner | Thu Nov 27 11:52am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 25 12:14pm ET |
| Started | RB | Omarion Hampton LAC | Owner | Tue Nov 25 12:14pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 12:14pm ET |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 12:14pm ET |
| Benched | WR | Jayden Higgins HOU | Owner | Tue Nov 25 12:14pm ET |
| Benched | RB | Justice Hill BAL | Owner | Tue Nov 25 12:14pm ET |
| Benched | WR | Greg Dortch ARI | Owner | Thu Nov 27 1:48am ET |
| Started | WR | Terry McLaurin WAS | Owner | Thu Nov 27 1:48am ET |
| Benched | TE | Pat Freiermuth PIT | Owner | Tue Nov 25 5:11pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 5:11pm ET |
| Benched | QB | Kirk Cousins ATL | Owner | Tue Nov 25 5:11pm ET |
| Benched | WR | DeAndre Hopkins BAL | Owner | Tue Nov 25 5:11pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 5:11pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 5:11pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 10:27am ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 10:27am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 10:27am ET |
| Benched | WR | Van Jefferson TEN | Owner | Tue Nov 25 10:27am ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 10:27am ET |
| Started | WR | John Metchie III NYJ | Owner | Tue Nov 25 10:27am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 10:27am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 10:27am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 8:48am ET |
| Benched | WR | Adonai Mitchell NYJ | Owner | Tue Nov 25 8:48am ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 8:48am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 8:48am ET |
| Benched | QB | Tua Tagovailoa MIA | Owner | Thu Nov 27 4:52pm ET |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 4:52pm ET |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 8:40pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 8:40pm ET |
| Benched | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 8:40pm ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 8:40pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 8:40pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:40pm ET |
| No starting lineup changes performed this week. |