

| Benched | QB | J.J. McCarthy MIN | Owner | Thu Nov 27 12:04pm ET |
| Started | QB | Tyrod Taylor NYJ | Owner | Thu Nov 27 12:04pm ET |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 25 8:37pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 8:37pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 9:56am ET |
| Benched | D/ST | Minnesota Vikings MIN | Owner | Tue Nov 25 9:56am ET |
| Started | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 9:56am ET |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Tue Nov 25 9:56am ET |
| Benched | QB | Caleb Williams CHI | Owner | Wed Nov 26 12:16pm ET |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 12:16pm ET |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 4:22pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 4:22pm ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 4:21pm ET |
| Benched | TE | Colston Loveland CHI | Owner | Tue Nov 25 4:21pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 4:21pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 4:21pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Wed Nov 26 3:29pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 3:29pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 5:59am ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 5:29pm ET |
| Benched | TE | Juwan Johnson NO | Owner | Wed Nov 26 5:29pm ET |
| Benched | TE | Cade Otton TB | Owner | Wed Nov 26 5:29pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 5:29pm ET |
| Started | WR | Xavier Worthy KC | Owner | Wed Nov 26 5:29pm ET |
| Started | TE | Luke Musgrave GB | Owner | Wed Nov 26 5:29pm ET |
| Benched | TE | Noah Fant CIN | Owner | Thu Nov 27 9:44am ET |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 9:44am ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 9:08am ET |
| Benched | WR | Rome Odunze CHI | Owner | Wed Nov 26 9:08am ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 9:08am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 9:08am ET |
| Benched | WR | Greg Dortch ARI | Owner | Thu Nov 27 11:20am ET |
| Started | WR | Mack Hollins NE | Owner | Thu Nov 27 11:20am ET |
| Benched | WR | Dontayvion Wicks GB | Owner | Thu Nov 27 11:19am ET |
| Started | WR | Greg Dortch ARI | Owner | Thu Nov 27 11:19am ET |
| Benched | WR | Mack Hollins NE | Owner | Thu Nov 27 12:17am ET |
| Started | WR | Dontayvion Wicks GB | Owner | Thu Nov 27 12:17am ET |
| Benched | TE | Dalton Schultz HOU | Owner | Wed Nov 26 12:45am ET |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 12:45am ET |
| Started | TE | T.J. Hockenson MIN | Owner | Sat Nov 29 6:57pm ET |
| Benched | TE | Darren Waller MIA | Owner | Sat Nov 29 6:57pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 10:39pm ET |
| Benched | QB | Jared Goff DET | Owner | Wed Nov 26 10:39pm ET |
| Started | TE | Darren Waller MIA | Owner | Tue Nov 25 6:14pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 25 6:14pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 6:14pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 6:14pm ET |
| Benched | TE | Mason Taylor NYJ | Owner | Tue Nov 25 6:14pm ET |
| Benched | TE | T.J. Hockenson MIN | Owner | Tue Nov 25 6:14pm ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Tue Nov 25 6:14pm ET |
| Benched | RB | Keaton Mitchell BAL | Owner | Tue Nov 25 6:14pm ET |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Thu Nov 27 10:03am ET |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 10:03am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 10:03am ET |
| Benched | RB | Aaron Jones MIN | Owner | Wed Nov 26 4:43pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 4:43pm ET |
| Benched | WR | Troy Franklin DEN | Owner | Wed Nov 26 4:42pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 4:42pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 4:41pm ET |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 4:41pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 3:23pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 3:23pm ET |
| No starting lineup changes performed this week. |