

| No starting lineup changes performed this week. |
| Benched | QB | J.J. McCarthy MIN | Owner | Sun Dec 14 8:43am ET |
| Started | QB | Marcus Mariota WAS | Owner | Sun Dec 14 8:43am ET |
| Benched | QB | Tyrod Taylor NYJ | Owner | Tue Dec 9 5:09pm ET |
| Benched | RB | Jordan Mason MIN | Owner | Tue Dec 9 5:09pm ET |
| Benched | TE | Isaiah Likely BAL | Owner | Tue Dec 9 5:09pm ET |
| Started | QB | J.J. McCarthy MIN | Owner | Tue Dec 9 5:09pm ET |
| Started | RB | TreVeyon Henderson NE | Owner | Tue Dec 9 5:09pm ET |
| Started | TE | Theo Johnson NYG | Owner | Tue Dec 9 5:09pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Jordan Love GB | Owner | Tue Dec 9 3:59pm ET |
| Benched | WR | Adonai Mitchell NYJ | Owner | Tue Dec 9 3:59pm ET |
| Started | QB | Lamar Jackson BAL | Owner | Tue Dec 9 3:59pm ET |
| Started | WR | Zay Flowers BAL | Owner | Tue Dec 9 3:59pm ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Sun Dec 14 12:41pm ET |
| Benched | RB | Jaylen Warren PIT | Owner | Sun Dec 14 12:41pm ET |
| Started | WR | Chris Godwin TB | Owner | Thu Dec 11 6:31pm ET |
| Benched | WR | Christian Watson GB | Owner | Thu Dec 11 6:31pm ET |
| Started | QB | Jacoby Brissett ARI | Owner | Thu Dec 11 6:09am ET |
| Benched | QB | Justin Herbert LAC | Owner | Thu Dec 11 6:09am ET |
| Started | D/ST | San Francisco 49ers SF | Owner | Wed Dec 10 2:36pm ET |
| Started | WR | Tetairoa McMillan CAR | Owner | Wed Dec 10 2:36pm ET |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Wed Dec 10 2:36pm ET |
| Benched | WR | Chris Godwin TB | Owner | Wed Dec 10 2:36pm ET |
| No starting lineup changes performed this week. |
| Benched | D/ST | Los Angeles Rams LAR | Owner | Thu Dec 11 6:21pm ET |
| Started | D/ST | Houston Texans HOU | Owner | Thu Dec 11 6:21pm ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Thu Dec 11 6:21pm ET |
| Started | TE | George Kittle SF | Owner | Thu Dec 11 6:21pm ET |
| Benched | TE | Tyler Warren IND | Owner | Wed Dec 10 9:45am ET |
| Started | TE | Harold Fannin Jr. CLE | Owner | Wed Dec 10 9:45am ET |
| Benched | WR | Mack Hollins NE | Owner | Tue Dec 9 9:46pm ET |
| Started | TE | Hunter Henry NE | Owner | Tue Dec 9 9:46pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Dec 9 6:25pm ET |
| Benched | WR | Dontayvion Wicks GB | Owner | Tue Dec 9 6:25pm ET |
| Benched | D/ST | Indianapolis Colts IND | Owner | Tue Dec 9 6:25pm ET |
| Started | RB | Omarion Hampton LAC | Owner | Tue Dec 9 6:25pm ET |
| Started | WR | Mack Hollins NE | Owner | Tue Dec 9 6:25pm ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Tue Dec 9 6:25pm ET |
| Started | RB | Chuba Hubbard CAR | Owner | Sun Dec 14 12:43am ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Sun Dec 14 12:43am ET |
| Started | K | Cam Little JAX | Owner | Sun Dec 14 12:43am ET |
| Started | WR | Jerry Jeudy CLE | Owner | Wed Dec 10 11:42pm ET |
| Benched | WR | Drake London ATL | Owner | Wed Dec 10 11:42pm ET |
| Started | WR | Drake London ATL | Owner | Tue Dec 9 3:47pm ET |
| Started | RB | Rico Dowdle CAR | Owner | Tue Dec 9 3:47pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Dec 9 3:47pm ET |
| Benched | WR | D.J. Moore CHI | Owner | Tue Dec 9 3:47pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Dec 9 3:47pm ET |
| Benched | QB | Jared Goff DET | Owner | Tue Dec 9 3:47pm ET |
| Benched | D/ST | Denver Broncos DEN | Owner | Thu Dec 11 2:27pm ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Thu Dec 11 2:27pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Dec 11 2:27pm ET |
| Started | RB | Christian McCaffrey SF | Owner | Thu Dec 11 2:27pm ET |
| No starting lineup changes performed this week. |
| Started | K | Andres Borregales NE | Owner | Sun Dec 14 12:51pm ET |