

| Benched | QB | J.J. McCarthy MIN | Owner | Thu Nov 27 11:04am CT |
| Started | QB | Tyrod Taylor NYJ | Owner | Thu Nov 27 11:04am CT |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 25 7:37pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 7:37pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 8:56am CT |
| Benched | D/ST | Minnesota Vikings MIN | Owner | Tue Nov 25 8:56am CT |
| Started | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 8:56am CT |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Tue Nov 25 8:56am CT |
| Benched | QB | Caleb Williams CHI | Owner | Wed Nov 26 11:16am CT |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 11:16am CT |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 3:22pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 3:22pm CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 3:21pm CT |
| Benched | TE | Colston Loveland CHI | Owner | Tue Nov 25 3:21pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 3:21pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 3:21pm CT |
| Benched | WR | Jordan Addison MIN | Owner | Wed Nov 26 2:29pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 2:29pm CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 4:59am CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 4:29pm CT |
| Benched | TE | Juwan Johnson NO | Owner | Wed Nov 26 4:29pm CT |
| Benched | TE | Cade Otton TB | Owner | Wed Nov 26 4:29pm CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 4:29pm CT |
| Started | WR | Xavier Worthy KC | Owner | Wed Nov 26 4:29pm CT |
| Started | TE | Luke Musgrave GB | Owner | Wed Nov 26 4:29pm CT |
| Benched | TE | Noah Fant CIN | Owner | Thu Nov 27 8:44am CT |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 8:44am CT |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 8:08am CT |
| Benched | WR | Rome Odunze CHI | Owner | Wed Nov 26 8:08am CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 8:08am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 8:08am CT |
| Benched | WR | Greg Dortch ARI | Owner | Thu Nov 27 10:20am CT |
| Started | WR | Mack Hollins NE | Owner | Thu Nov 27 10:20am CT |
| Benched | WR | Dontayvion Wicks GB | Owner | Thu Nov 27 10:19am CT |
| Started | WR | Greg Dortch ARI | Owner | Thu Nov 27 10:19am CT |
| Benched | WR | Mack Hollins NE | Owner | Wed Nov 26 11:17pm CT |
| Started | WR | Dontayvion Wicks GB | Owner | Wed Nov 26 11:17pm CT |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 11:45pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 11:45pm CT |
| Started | TE | T.J. Hockenson MIN | Owner | Sat Nov 29 5:57pm CT |
| Benched | TE | Darren Waller MIA | Owner | Sat Nov 29 5:57pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 9:39pm CT |
| Benched | QB | Jared Goff DET | Owner | Wed Nov 26 9:39pm CT |
| Started | TE | Darren Waller MIA | Owner | Tue Nov 25 5:14pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 25 5:14pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 5:14pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 5:14pm CT |
| Benched | TE | Mason Taylor NYJ | Owner | Tue Nov 25 5:14pm CT |
| Benched | TE | T.J. Hockenson MIN | Owner | Tue Nov 25 5:14pm CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Tue Nov 25 5:14pm CT |
| Benched | RB | Keaton Mitchell BAL | Owner | Tue Nov 25 5:14pm CT |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Thu Nov 27 9:03am CT |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 9:03am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 9:03am CT |
| Benched | RB | Aaron Jones MIN | Owner | Wed Nov 26 3:43pm CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 3:43pm CT |
| Benched | WR | Troy Franklin DEN | Owner | Wed Nov 26 3:42pm CT |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 3:42pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 3:41pm CT |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 3:41pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 2:23pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 2:23pm CT |
| No starting lineup changes performed this week. |