

| Benched | TE | Dawson Knox BUF | Owner | Thu Nov 27 1:46am ET |
| Started | TE | Colby Parkinson LAR | Owner | Thu Nov 27 1:46am ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 5:11pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 5:11pm ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Wed Nov 26 5:04pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 5:04pm ET |
| Benched | K | Andres Borregales NE | Owner | Tue Nov 25 7:38pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 7:38pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 10:32am ET |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 25 10:32am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 10:32am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 10:32am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 4:06pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 4:06pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 4:05pm ET |
| Started | WR | Darnell Mooney ATL | Owner | Tue Nov 25 4:05pm ET |
| Benched | WR | Kayshon Boutte NE | Owner | Sun Nov 30 12:08pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Sun Nov 30 12:08pm ET |
| Benched | RB | Sean Tucker TB | Owner | Sun Nov 30 12:07pm ET |
| Started | RB | Bucky Irving TB | Owner | Sun Nov 30 12:07pm ET |
| Benched | WR | Tre Tucker LV | Owner | Thu Nov 27 11:54am ET |
| Started | WR | Kayshon Boutte NE | Owner | Thu Nov 27 11:54am ET |
| Benched | QB | Brock Purdy SF | Owner | Sat Nov 29 11:48pm ET |
| Started | QB | Daniel Jones IND | Owner | Sat Nov 29 11:48pm ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 3:46pm ET |
| Started | WR | Michael Wilson ARI | Owner | Tue Nov 25 3:46pm ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 4:44pm ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 4:44pm ET |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 4:44pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 4:44pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 4:44pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 4:44pm ET |
| Started | RB | Tyjae Spears TEN | Owner | Sat Nov 29 11:58am ET |
| Benched | WR | Chimere Dike TEN | Owner | Sat Nov 29 11:58am ET |
| Started | WR | Chimere Dike TEN | Owner | Sat Nov 29 11:56am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Sat Nov 29 11:56am ET |
| Started | WR | Deebo Samuel WAS | Owner | Sat Nov 29 9:58am ET |
| Benched | WR | Chris Olave NO | Owner | Sat Nov 29 9:58am ET |
| Started | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 1:55pm ET |
| Benched | TE | Hunter Henry NE | Owner | Wed Nov 26 1:55pm ET |
| Started | TE | Hunter Henry NE | Owner | Tue Nov 25 8:25pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 25 8:25pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 10:31am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 10:31am ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 10:31am ET |
| Benched | TE | Hunter Henry NE | Owner | Tue Nov 25 10:31am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 10:31am ET |
| Benched | QB | Tyler Shough NO | Owner | Tue Nov 25 10:31am ET |
| Benched | WR | Xavier Legette CAR | Owner | Tue Nov 25 1:47pm ET |
| Benched | D/ST | Chicago Bears CHI | Owner | Tue Nov 25 1:47pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 1:47pm ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Tue Nov 25 1:47pm ET |
| No starting lineup changes performed this week. |
| Started | WR | Parker Washington JAX | Owner | Sun Nov 30 12:55pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Sun Nov 30 12:55pm ET |
| Started | TE | Theo Johnson NYG | Owner | Sun Nov 30 12:19am ET |
| Benched | TE | T.J. Hockenson MIN | Owner | Sun Nov 30 12:19am ET |
| Benched | WR | Parker Washington JAX | Owner | Wed Nov 26 5:41pm ET |
| Benched | TE | Theo Johnson NYG | Owner | Wed Nov 26 5:41pm ET |
| Started | WR | Jauan Jennings SF | Owner | Wed Nov 26 5:41pm ET |
| Started | TE | T.J. Hockenson MIN | Owner | Wed Nov 26 5:41pm ET |
| Started | D/ST | New England Patriots NE | Owner | Tue Nov 25 7:45am ET |
| Started | TE | Theo Johnson NYG | Owner | Tue Nov 25 7:45am ET |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 25 7:45am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 7:45am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 7:45am ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 7:45am ET |
| Benched | TE | Noah Fant CIN | Owner | Tue Nov 25 7:45am ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Tue Nov 25 7:45am ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 7:45am ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:45am ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 7:45am ET |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 7:45am ET |