

| Benched | TE | Dawson Knox BUF | Owner | Thu Nov 27 12:46am CT |
| Started | TE | Colby Parkinson LAR | Owner | Thu Nov 27 12:46am CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 4:11pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 4:11pm CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Wed Nov 26 4:04pm CT |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 4:04pm CT |
| Benched | K | Andres Borregales NE | Owner | Tue Nov 25 6:38pm CT |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 6:38pm CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 9:32am CT |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 25 9:32am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 9:32am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 9:32am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 3:06pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 3:06pm CT |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 3:05pm CT |
| Started | WR | Darnell Mooney ATL | Owner | Tue Nov 25 3:05pm CT |
| Benched | WR | Kayshon Boutte NE | Owner | Sun Nov 30 11:08am CT |
| Started | WR | Terry McLaurin WAS | Owner | Sun Nov 30 11:08am CT |
| Benched | RB | Sean Tucker TB | Owner | Sun Nov 30 11:07am CT |
| Started | RB | Bucky Irving TB | Owner | Sun Nov 30 11:07am CT |
| Benched | WR | Tre Tucker LV | Owner | Thu Nov 27 10:54am CT |
| Started | WR | Kayshon Boutte NE | Owner | Thu Nov 27 10:54am CT |
| Benched | QB | Brock Purdy SF | Owner | Sat Nov 29 10:48pm CT |
| Started | QB | Daniel Jones IND | Owner | Sat Nov 29 10:48pm CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 2:46pm CT |
| Started | WR | Michael Wilson ARI | Owner | Tue Nov 25 2:46pm CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 3:44pm CT |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 3:44pm CT |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 3:44pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 3:44pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 3:44pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 3:44pm CT |
| Started | RB | Tyjae Spears TEN | Owner | Sat Nov 29 10:58am CT |
| Benched | WR | Chimere Dike TEN | Owner | Sat Nov 29 10:58am CT |
| Started | WR | Chimere Dike TEN | Owner | Sat Nov 29 10:56am CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Sat Nov 29 10:56am CT |
| Started | WR | Deebo Samuel WAS | Owner | Sat Nov 29 8:58am CT |
| Benched | WR | Chris Olave NO | Owner | Sat Nov 29 8:58am CT |
| Started | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 12:55pm CT |
| Benched | TE | Hunter Henry NE | Owner | Wed Nov 26 12:55pm CT |
| Started | TE | Hunter Henry NE | Owner | Tue Nov 25 7:25pm CT |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 25 7:25pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 9:31am CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 9:31am CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 9:31am CT |
| Benched | TE | Hunter Henry NE | Owner | Tue Nov 25 9:31am CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 9:31am CT |
| Benched | QB | Tyler Shough NO | Owner | Tue Nov 25 9:31am CT |
| Benched | WR | Xavier Legette CAR | Owner | Tue Nov 25 12:47pm CT |
| Benched | D/ST | Chicago Bears CHI | Owner | Tue Nov 25 12:47pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 12:47pm CT |
| Started | D/ST | Buffalo Bills BUF | Owner | Tue Nov 25 12:47pm CT |
| No starting lineup changes performed this week. |
| Started | WR | Parker Washington JAX | Owner | Sun Nov 30 11:55am CT |
| Benched | WR | Jauan Jennings SF | Owner | Sun Nov 30 11:55am CT |
| Started | TE | Theo Johnson NYG | Owner | Sat Nov 29 11:19pm CT |
| Benched | TE | T.J. Hockenson MIN | Owner | Sat Nov 29 11:19pm CT |
| Benched | WR | Parker Washington JAX | Owner | Wed Nov 26 4:41pm CT |
| Benched | TE | Theo Johnson NYG | Owner | Wed Nov 26 4:41pm CT |
| Started | WR | Jauan Jennings SF | Owner | Wed Nov 26 4:41pm CT |
| Started | TE | T.J. Hockenson MIN | Owner | Wed Nov 26 4:41pm CT |
| Started | D/ST | New England Patriots NE | Owner | Tue Nov 25 6:45am CT |
| Started | TE | Theo Johnson NYG | Owner | Tue Nov 25 6:45am CT |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 25 6:45am CT |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 6:45am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 6:45am CT |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 6:45am CT |
| Benched | TE | Noah Fant CIN | Owner | Tue Nov 25 6:45am CT |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Tue Nov 25 6:45am CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 6:45am CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 6:45am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 6:45am CT |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 6:45am CT |