

| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 2:31am CT |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 10:55pm CT |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 25 10:55pm CT |
| Benched | WR | Michael Wilson ARI | Owner | Sat Nov 29 10:00pm CT |
| Started | WR | Chris Olave NO | Owner | Sat Nov 29 10:00pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Sat Nov 29 10:19am CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Sat Nov 29 10:19am CT |
| Started | WR | D.K. Metcalf PIT | Owner | Fri Nov 28 12:08am CT |
| Benched | RB | D'Andre Swift CHI | Owner | Fri Nov 28 12:08am CT |
| Started | RB | D'Andre Swift CHI | Owner | Thu Nov 27 7:27am CT |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Thu Nov 27 7:27am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 8:36pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Wed Nov 26 8:36pm CT |
| Started | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 8:36pm CT |
| Started | RB | Ashton Jeanty LV | Owner | Wed Nov 26 8:36pm CT |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Wed Nov 26 8:36pm CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 8:36pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 8:36pm CT |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 8:36pm CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 11:57am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Brian Robinson Jr. SF | Owner | Thu Nov 27 10:50am CT |
| Started | RB | Isiah Pacheco KC | Owner | Thu Nov 27 10:50am CT |
| Benched | RB | Tyler Allgeier ATL | Owner | Wed Nov 26 8:48pm CT |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 8:48pm CT |
| Benched | QB | Jordan Love GB | Owner | Thu Nov 27 11:16am CT |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 11:16am CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Thu Nov 27 9:49am CT |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 9:49am CT |
| Started | WR | Deebo Samuel WAS | Owner | Sat Nov 29 11:17am CT |
| Benched | WR | Chimere Dike TEN | Owner | Sat Nov 29 11:17am CT |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 8:44am CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Sat Nov 29 8:44am CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 12:56pm CT |
| Benched | WR | Deebo Samuel WAS | Owner | Wed Nov 26 12:56pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 9:33am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 9:33am CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 9:33am CT |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 9:33am CT |
| Benched | TE | Dallas Goedert PHI | Owner | Thu Nov 27 9:42am CT |
| Started | WR | Parker Washington JAX | Owner | Thu Nov 27 9:42am CT |
| Benched | D/ST | New England Patriots NE | Owner | Thu Nov 27 11:01am CT |
| Started | D/ST | Cleveland Browns CLE | Owner | Thu Nov 27 11:01am CT |
| Benched | TE | Tyler Warren IND | Owner | Tue Nov 25 11:17pm CT |
| Started | TE | Jake Ferguson DAL | Owner | Tue Nov 25 11:17pm CT |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 11:17pm CT |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 9:10pm CT |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 9:10pm CT |